| Literature DB >> 30119996 |
Akira Goto1, Kiyoshi Okado2, Nelson Martins3, Hua Cai3, Vincent Barbier2, Olivier Lamiable2, Laurent Troxler2, Estelle Santiago2, Lauriane Kuhn4, Donggi Paik5, Neal Silverman5, Andreas Holleufer6, Rune Hartmann6, Jiyong Liu7, Tao Peng7, Jules A Hoffmann8, Carine Meignin2, Laurent Daeffler2, Jean-Luc Imler9.
Abstract
Antiviral immunity in Drosophila involves RNA interference and poorly characterized inducible responses. Here, we showed that two components of the IMD pathway, the kinase dIKKβ and the transcription factor Relish, were required to control infection by two picorna-like viruses. We identified a set of genes induced by viral infection and regulated by dIKKβ and Relish, which included an ortholog of STING. We showed that dSTING participated in the control of infection by picorna-like viruses, acting upstream of dIKKβ to regulate expression of Nazo, an antiviral factor. Our data reveal an antiviral function for STING in an animal model devoid of interferons and suggest an evolutionarily ancient role for this molecule in antiviral immunity.Entities:
Keywords: C19orf12; Dicistrovirus; Drosophila melanogaster; IKKβ; IMD pathway; NF-κB; STING; antiviral immunity; innate immunity; picornavirus
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Year: 2018 PMID： 30119996 PMCID： PMC6267954 DOI： 10.1016/j.immuni.2018.07.013
Source DB: PubMed Journal: Immunity ISSN： 1074-7613 Impact factor: 31.745