Literature DB >> 28086098

30 Years of NF-κB: A Blossoming of Relevance to Human Pathobiology.

Qian Zhang1, Michael J Lenardo2, David Baltimore3.   

Abstract

NF-κB was discovered 30 years ago as a rapidly inducible transcription factor. Since that time, it has been found to have a broad role in gene induction in diverse cellular responses, particularly throughout the immune system. Here, we summarize elaborate regulatory pathways involving this transcription factor and use recent discoveries in human genetic diseases to place specific proteins within their relevant medical and biological contexts. Published by Elsevier Inc.

Entities:  

Keywords:  I-κB; NF-κB; Rel; gene regulation; genetic disease; genomics; human gene; immunity; lymphocyte; transactivator

Mesh：

Substances：

Year:  2017        PMID： 28086098      PMCID： PMC5268070          DOI： 10.1016/j.cell.2016.12.012

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  138 in total

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Review 9.  Accessing Bioactive Natural Products from the Human Microbiome.

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Review 10.  Molecular mechanisms of viral oncogenesis in humans.

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Journal:  Nat Rev Microbiol       Date:  2018-11       Impact factor: 60.633
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