Helen Chung1, Sourabh Arora2, Karim F Damji2, Ezekiel Weis3. 1. Department of Surgery, Division of Ophthalmology, University of Calgary, Calgary, Alta. 2. Department of Ophthalmology and Visual Sciences, University of Alberta, Edmonton, Alta. 3. Department of Surgery, Division of Ophthalmology, University of Calgary, Calgary, Alta.; Department of Ophthalmology and Visual Sciences, University of Alberta, Edmonton, Alta.. Electronic address: ezekielweis@gmail.com.
Abstract
OBJECTIVE: Pseudoexfoliation syndrome (PEX) is a systemic disease, but evidence of its association with cardiovascular disease (CVD) and cerebrovascular disease (CVA) is controversial. A quantitative systematic review will provide an accurate summary of the current body of the literature. DESIGN: Meta-analysis. PARTICIPANTS: Not applicable. METHODS: A comprehensive literature search of published and unpublished English-language studies was performed. Summary statistics were calculated using inverse variance weighting and are presented in forest plots. Sources of variance were evaluated statistically. RESULTS: After screening 4547 studies, 47 articles were reviewed, and 25 eligible studies were selected that reported patients from around the world. Twenty studies enrolling 9583 individuals with PEX evaluated CVD, providing a summary odds ratio (OR) of 1.61 (95% CI 1.37-1.90). Eleven studies, enrolling 1308 PEX patients, evaluated CVA and generated a summary OR of 1.76 (1.40-2.22). For any vascular event (AVE) using all 25 studies, there were 9716 PEX patients and 363,312 control patients, yielding a summary OR of 1.64 (95% CI 1.39-1.92). Analysis for publication bias with the Egger's test was not significant for studies reporting CVD and AVE (p = 0.92 and 0.64, respectively) but was significant for CVA (p = 0.03). Asymmetry of Begg's funnel plot was noted for the CVA and AVE analyses. Multiple sensitivity analyses were performed, including assessment of study quality; the OR for all 3 outcomes varied minimally and remained significant in all analyses. CONCLUSION: There is strong evidence that PEX is significantly associated with both CVD and CVA.
OBJECTIVE:Pseudoexfoliation syndrome (PEX) is a systemic disease, but evidence of its association with cardiovascular disease (CVD) and cerebrovascular disease (CVA) is controversial. A quantitative systematic review will provide an accurate summary of the current body of the literature. DESIGN: Meta-analysis. PARTICIPANTS: Not applicable. METHODS: A comprehensive literature search of published and unpublished English-language studies was performed. Summary statistics were calculated using inverse variance weighting and are presented in forest plots. Sources of variance were evaluated statistically. RESULTS: After screening 4547 studies, 47 articles were reviewed, and 25 eligible studies were selected that reported patients from around the world. Twenty studies enrolling 9583 individuals with PEX evaluated CVD, providing a summary odds ratio (OR) of 1.61 (95% CI 1.37-1.90). Eleven studies, enrolling 1308 PEX patients, evaluated CVA and generated a summary OR of 1.76 (1.40-2.22). For any vascular event (AVE) using all 25 studies, there were 9716 PEX patients and 363,312 control patients, yielding a summary OR of 1.64 (95% CI 1.39-1.92). Analysis for publication bias with the Egger's test was not significant for studies reporting CVD and AVE (p = 0.92 and 0.64, respectively) but was significant for CVA (p = 0.03). Asymmetry of Begg's funnel plot was noted for the CVA and AVE analyses. Multiple sensitivity analyses were performed, including assessment of study quality; the OR for all 3 outcomes varied minimally and remained significant in all analyses. CONCLUSION: There is strong evidence that PEX is significantly associated with both CVD and CVA.
Authors: Alicia De Maria; Keith D Zientek; Larry L David; Phillip A Wilmarth; Anjali M Bhorade; George J Harocopos; Andrew J W Huang; Augustine R Hong; Carla J Siegfried; Linda M Tsai; Arsham Sheybani; Steven Bassnett Journal: Invest Ophthalmol Vis Sci Date: 2021-12-01 Impact factor: 4.799
Authors: Ahmad M Mansour; Anastasios G P Konstas; Hana A Mansour; Abdul R Charbaji; Khalil M El Jawhari Journal: Middle East Afr J Ophthalmol Date: 2021-04-30