| Literature DB >> 30119229 |
Rodrigo Pinheiro Araldi1, Thalita Araujo Sant'Ana2, Diego Grando Módolo2, Thatiana Correa de Melo3, Diva Denelle Spadacci-Morena4, Rita de Cassia Stocco2, Janete Maria Cerutti1, Edislane Barreiros de Souza5.
Abstract
Despite the novel diagnostic methods and therapies implemented in oncology, the number of patients that succumb by the cancer remains high globally. Currently studies point out that 20-25% of all human malignancies are related to micro-organism infections. Among these cancer-related pathogens, the human papillomavirus (HPV) has a prominent position, since the virus is responsible for about 30% of all infectious agent-related cancers. Thus, an amount of cancers could be avoided by means prophylactic and/or therapeutic measures. However, these measures required a holistic comprehension about HPV-related cancer biology. Based on this, this review aims to summarize the last evidences of HPV on cancer biology (from initiation to metastasis), focus on molecular and biochemical deregulations associated with viral infection, and discuss the viral etiology in different malignancies.Entities:
Keywords: Cancer progression; HPV; Metastasis; Mutation; Oncology
Mesh：
Substances：
Year: 2018 PMID： 30119229 DOI： 10.1016/j.biopha.2018.06.149
Source DB: PubMed Journal: Biomed Pharmacother ISSN： 0753-3322 Impact factor: 6.529