Literature DB >> 30118389

The role of trehalose in the global spread of epidemic Clostridium difficile.

James Collins1, Heather Danhof1, Robert A Britton1.   

Abstract

In a recent study, we reported on two distantly related, epidemic lineages of Clostridium difficile that have acquired independent mechanisms to metabolize low concentrations of trehalose. Here we provide further comment and evidence that a third epidemic lineage common in Asia and Europe, ribotype 017, has evolved this ability.

Entities:  

Keywords:  Clostridium difficile; RT017; enteric pathogen; ribotype 017; trehalose

Mesh：

Substances：

Year:  2018        PMID： 30118389      PMCID： PMC6546318          DOI： 10.1080/19490976.2018.1491266

Source DB:  PubMed          Journal:  Gut Microbes        ISSN： 1949-0976


  14 in total

1.  Degradation-resistant trehalose analogues block utilization of trehalose by hypervirulent Clostridioides difficile.

Authors:  Noah D Danielson; James Collins; Alicyn I Stothard; Qing Qing Dong; Karishma Kalera; Peter J Woodruff; Brian J DeBosch; Robert A Britton; Benjamin M Swarts
Journal:  Chem Commun (Camb)       Date:  2019-04-23       Impact factor: 6.222

2.  Microbial and metabolic impacts of trehalose and trehalose analogues.

Authors:  Yiming Zhang; Brian J DeBosch
Journal:  Gut Microbes       Date:  2020-04-24

Review 3.  From Nursery to Nursing Home: Emerging Concepts in Clostridioides difficile Pathogenesis.

Authors:  Alexander B Smith; Joshua Soto Ocana; Joseph P Zackular
Journal:  Infect Immun       Date:  2020-06-22       Impact factor: 3.441

4.  The Impact of pH on Clostridioides difficile Sporulation and Physiology.

Authors:  Daniela Wetzel; Shonna M McBride
Journal:  Appl Environ Microbiol       Date:  2020-02-03       Impact factor: 4.792

Review 5.  Carbohydrate-active enzymes (CAZymes) in the gut microbiome.

Authors:  Jacob F Wardman; Rajneesh K Bains; Peter Rahfeld; Stephen G Withers
Journal:  Nat Rev Microbiol       Date:  2022-03-28       Impact factor: 78.297

6.  The role of chemoenzymatic synthesis in advancing trehalose analogues as tools for combatting bacterial pathogens.

Authors:  Karishma Kalera; Alicyn I Stothard; Peter J Woodruff; Benjamin M Swarts
Journal:  Chem Commun (Camb)       Date:  2020-10-01       Impact factor: 6.222

7.  Lactotrehalose, an Analog of Trehalose, Increases Energy Metabolism Without Promoting Clostridioides difficile Infection in Mice.

Authors:  Yiming Zhang; Nurmohammad Shaikh; Jeremie L Ferey; Umesh D Wankhade; Sree V Chintapalli; Cassandra B Higgins; Jan R Crowley; Monique R Heitmeier; Alicyn I Stothard; Belgacem Mihi; Misty Good; Takanobu Higashiyama; Benjamin M Swarts; Paul W Hruz; Kartik Shankar; Phillip I Tarr; Brian J DeBosch
Journal:  Gastroenterology       Date:  2019-12-12       Impact factor: 22.682

Review 8.  Using trehalose to prevent and treat metabolic function: effectiveness and mechanisms.

Authors:  Yiming Zhang; Brian J DeBosch
Journal:  Curr Opin Clin Nutr Metab Care       Date:  2019-07       Impact factor: 4.294

Review 9.  Gut Microbiota and Colonization Resistance against Bacterial Enteric Infection.

Authors:  Q R Ducarmon; R D Zwittink; B V H Hornung; W van Schaik; V B Young; E J Kuijper
Journal:  Microbiol Mol Biol Rev       Date:  2019-06-05       Impact factor: 11.056

10.  Trehalose-Induced Remodelling of the Human Microbiota Affects Clostridioides difficile Infection Outcome in an In Vitro Colonic Model: A Pilot Study.

Authors:  Anthony M Buckley; Ines B Moura; Norie Arai; William Spittal; Emma Clark; Yoshihiro Nishida; Hannah C Harris; Karen Bentley; Georgina Davis; Dapeng Wang; Suparna Mitra; Takanobu Higashiyama; Mark H Wilcox
Journal:  Front Cell Infect Microbiol       Date:  2021-07-02       Impact factor: 5.293
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