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Literature DB >> 3011492

Hydroxyl radicals are not involved in NADPH dependent microsomal lipid peroxidation.

Abstract

NADPH dependent H2O2 formation in microsomes in the presence of chelated iron leads to formation of hydroxyl radicals. Enhancement of hydroxyl radical generation (via ferric-EDTA or sodium azide) did not result in a concomitant increase in lipid peroxidation; rather, a decrease was observed. Moreover, the hydroxyl radical scavenger DMSO did not inhibit lipid peroxidation. This comparison of hydroxyl radical formation with lipid peroxidation suggests that hydroxyl radicals do not play a part in NADPH-dependent lipid peroxidation.

Entities: Chemical

Mesh：

Substances：

Year: 1986 PMID： 3011492 DOI： 10.1007/bf01946700

Source DB: PubMed Journal: Experientia ISSN： 0014-4754

11 in total

10. Adriamycin-iron catalysed phospholipid peroxidation: a reaction not involving reduced adriamycin or hydroxyl radicals.

Authors: J M Gutteridge
Journal: Biochem Pharmacol Date: 1983-06-15 Impact factor: 5.858

2 in total

Review 1. Free radicals and oxygen toxicity.

Authors: D D Buechter
Journal: Pharm Res Date: 1988-05 Impact factor: 4.200

2. Effect of oxygen concentration on microsomal oxidation of ethanol and generation of oxygen radicals.

Authors: S Puntarulo; A I Cederbaum
Journal: Biochem J Date: 1988-05-01 Impact factor: 3.857

2 in total

Hydroxyl radicals are not involved in NADPH dependent microsomal lipid peroxidation.

1. The colorimetric estimation of formaldehyde by means of the Hantzsch reaction.

2. Protein measurement with the Folin phenol reagent.

3. Production of formaldehyde during metabolism of dimethyl sulfoxide by hydroxyl radical generating systems.

4. The role of superoxide and hydroxyl radicals in phospholipid peroxidation catalysed by iron salts.

5. Protection against lipid peroxidation by a microsomal glutathione-dependent labile factor.

6. Superoxide dependent lipid peroxidation.

7. Cytochrome P450 oxidase activity and its role in NADPH dependent lipid peroxidation.

8. Effect of hydrogen peroxide on the initiation of microsomal lipid peroxidation.

9. On the significance of the cytochrome P-450-dependent hydroxyl radical-mediated oxygenation mechanism.

10. Adriamycin-iron catalysed phospholipid peroxidation: a reaction not involving reduced adriamycin or hydroxyl radicals.

Review 1. Free radicals and oxygen toxicity.

2. Effect of oxygen concentration on microsomal oxidation of ethanol and generation of oxygen radicals.