Literature DB >> 3011412

The immunoglobulin heavy-chain B-lymphocyte enhancer efficiently stimulates transcription in non-lymphoid cells.

C Wasylyk, B Wasylyk.   

Abstract

The mouse immunoglobulin heavy-chain (IgH) B-lymphocyte enhancer stimulates transcription from heterologous promoters 20- to 40-fold when transfected into several non-lymphoid cell lines. Stimulation in B-lymphocyte melanoma cell-lines is only about 5--10 times better. A central sequence is equally active in both cell types, whilst flanking sequences, on either side of the common enhancer sequences, specifically stimulate transcription in myeloma cells. These results suggest that there are factors in non-lymphoid cells that can interact with the IgH enhancer to stimulate transcription.

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Year:  1986        PMID： 3011412      PMCID： PMC1166798          DOI： 10.1002/j.1460-2075.1986.tb04246.x

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


  42 in total

1.  C mu-containing transcripts initiate heterogeneously within the IgH enhancer region and contain a novel 5'-nontranslatable exon.

Authors:  G G Lennon; R P Perry
Journal:  Nature       Date:  1985 Dec 5-11       Impact factor: 49.962

2.  Phenotype and hybrids between lymphoid cells and rat hepatoma cells.

Authors:  S Junker
Journal:  Exp Cell Res       Date:  1982-05       Impact factor: 3.905

3.  The SV40 72 base repair repeat has a striking effect on gene expression both in SV40 and other chimeric recombinants.

Authors:  P Moreau; R Hen; B Wasylyk; R Everett; M P Gaub; P Chambon
Journal:  Nucleic Acids Res       Date:  1981-11-25       Impact factor: 16.971

4.  Transcriptional control signals of a eukaryotic protein-coding gene.

Authors:  S L McKnight; R Kingsbury
Journal:  Science       Date:  1982-07-23       Impact factor: 47.728

5.  The switch region associated with immunoglobulin C mu genes is DNase I hypersensitive in T lymphocytes.

Authors:  U Storb; B Arp; R Wilson
Journal:  Nature       Date:  1981-11-05       Impact factor: 49.962

6.  Immunoglobulin heavy chain gene rearrangement and transcription in murine T cell hybrids and T lymphomas.

Authors:  M C Züñiga; P D'Eustachio; N H Ruddle
Journal:  Proc Natl Acad Sci U S A       Date:  1982-05       Impact factor: 11.205

7.  Enhancing the efficiency of DNA-mediated gene transfer in mammalian cells.

Authors:  C M Corsaro; M L Pearson
Journal:  Somatic Cell Genet       Date:  1981-09

8.  Expression of immunoglobulin synthesis in human myeloma x non-lymphoid cell heterokaryons: evidence for negative control.

Authors:  J Zeuthen; S Stenman; H A Fabricius; K Nilsson
Journal:  Cell Differ       Date:  1976-03

9.  Multiple immunoglobulin heavy-chain gene transcripts in Abelson murine leukemia virus-transformed lymphoid cell lines.

Authors:  F W Alt; N Rosenberg; V Enea; E Siden; D Baltimore
Journal:  Mol Cell Biol       Date:  1982-04       Impact factor: 4.272

10.  A small segment of polyoma virus DNA enhances the expression of a cloned beta-globin gene over a distance of 1400 base pairs.

Authors:  J de Villiers; W Schaffner
Journal:  Nucleic Acids Res       Date:  1981-12-11       Impact factor: 16.971
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  59 in total

1.  Variegated expression of the endogenous immunoglobulin heavy-chain gene in the absence of the intronic locus control region.

Authors:  D Ronai; M Berru; M J Shulman
Journal:  Mol Cell Biol       Date:  1999-10       Impact factor: 4.272

2.  Octamer-binding proteins in diverse hemopoietic cells.

Authors:  P N Cockerill; S P Klinken
Journal:  Mol Cell Biol       Date:  1990-03       Impact factor: 4.272

3.  B-lymphocyte targeting of gene expression in transgenic mice with the immunoglobulin heavy-chain enhancer.

Authors:  P Gerlinger; M LeMeur; C Irrmann; P Renard; C Wasylyk; B Wasylyk
Journal:  Nucleic Acids Res       Date:  1986-08-26       Impact factor: 16.971

4.  Functional analysis of the murine IgH enhancer: evidence for negative control of cell-type specificity.

Authors:  T Kadesch; P Zervos; D Ruezinsky
Journal:  Nucleic Acids Res       Date:  1986-10-24       Impact factor: 16.971

5.  Functional analysis of defined mutations in the immunoglobulin heavy-chain enhancer in transgenic mice.

Authors:  A Annweiler; U Müller; T Wirth
Journal:  Nucleic Acids Res       Date:  1992-04-11       Impact factor: 16.971

6.  Positive and negative regulation of immunoglobulin gene expression by a novel B-cell-specific enhancer element.

Authors:  J Wang; M Oketani; T Watanabe
Journal:  Mol Cell Biol       Date:  1991-01       Impact factor: 4.272

7.  The lack of transcriptional activation of the v-erbA oncogene is in part due to a mutation present in the DNA binding domain of the protein.

Authors:  H de Verneuil; D Metzger
Journal:  Nucleic Acids Res       Date:  1990-08-11       Impact factor: 16.971

8.  Negative regulation contributes to tissue specificity of the immunoglobulin heavy-chain enhancer.

Authors:  J L Imler; C Lemaire; C Wasylyk; B Wasylyk
Journal:  Mol Cell Biol       Date:  1987-07       Impact factor: 4.272

9.  Recombination and transcription of the endogenous Ig heavy chain locus is effected by the Ig heavy chain intronic enhancer core region in the absence of the matrix attachment regions.

Authors:  E Sakai; A Bottaro; L Davidson; B P Sleckman; F W Alt
Journal:  Proc Natl Acad Sci U S A       Date:  1999-02-16       Impact factor: 11.205

10.  Transient expression directed by homologous and heterologous promoter and enhancer sequences in fish cells.

Authors:  H Friedenreich; M Schartl
Journal:  Nucleic Acids Res       Date:  1990-06-11       Impact factor: 16.971
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