Kerstin Soelberg1,2,3,4,5, Svenja Specovius6,7,8,9, Hanna G Zimmermann6,7,8,9, Jakob Grauslund5,10, Jesper J Mehlsen11, Clement Olesen1, Allan S B Neve1, Friedemann Paul6,7,8,9,12, Alexander U Brandt6,7,8,9,13, Nasrin Asgari1,2,3. 1. Institutes of Regional Health Research and Molecular Medicine, University of Southern Denmark, Odense, Denmark. 2. OPEN, Odense Patient data Explorative Network, Odense University Hospital, Odense, Denmark. 3. Department of Neurology, Slagelse Hospital, Slagelse, Denmark. 4. Department of Neurology, Lillebaelt Hospital, Vejle, Denmark. 5. Department of Ophthalmology, Odense University Hospital, Odense, Denmark. 6. NeuroCure Clinical Research Center, Charité - Universitätsmedizin Berlin, Berlin, Germany. 7. Freie Universität Berlin, Berlin, Germany. 8. Humboldt-Universität zu Berlin, Berlin, Germany. 9. Berlin Institute of Health, Berlin, Germany. 10. Department of Clinical Research, University of Southern Denmark, Odense, Denmark. 11. Department of Ophthalmology, Lillebaelt Hospital, Vejle, Denmark. 12. Max Delbrueck Center for Molecular Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany. 13. Department of Neurology, University of California Irvine, Irvine, CA, USA.
Abstract
OBJECTIVES: To measure early structural damage caused by autoimmune inflammatory optic neuritis (ON) by optical coherence tomography (OCT) in a population-based cohort. METHODS: In a prospective population-based study over 24 months in Southern Denmark, patients diagnosed with acute ON and without prior diagnosis of a chronic neuroinflammatory disorder were included and examined with OCT, visual evoked potentials (VEP), visual fields, high contrast visual acuity (HCVA), and low contrast letter acuity (LCLA). Structural and functional outcomes were determined at 6-month follow-up based on interocular differences. RESULTS: The 50 included patients had on average 16.9 μm peripapillary retinal nerve fiber layer loss, 10.6 μm ganglion cell and inner plexiform layer (GCIP) loss, and an average HCVA decrease of 0.22 dec. Based on a linear regression model, average GCIP loss amounted to -0.2 μm per day and started 8 days after onset. OCT outcomes but not VEP correlated well with all visual function measurements at follow-up. Structural and functional damage in 20 patients (40%) diagnosed de novo with multiple sclerosis (MS) and in 2 patients (4%) with positive myelin oligodendrocyte glycoprotein antibodies (MOG-IgG) test did not differ from patients with idiopathic ON. CONCLUSIONS: Optic neuritis causes substantial retinal damage and vision loss independent of the underlying disease. Our study supports that GCIP damage starts closely to clinical onset. Good structure-function correlations between OCT and vision support the importance of OCT in monitoring acute ON.
OBJECTIVES: To measure early structural damage caused by autoimmune inflammatory optic neuritis (ON) by optical coherence tomography (OCT) in a population-based cohort. METHODS: In a prospective population-based study over 24 months in Southern Denmark, patients diagnosed with acute ON and without prior diagnosis of a chronic neuroinflammatory disorder were included and examined with OCT, visual evoked potentials (VEP), visual fields, high contrast visual acuity (HCVA), and low contrast letter acuity (LCLA). Structural and functional outcomes were determined at 6-month follow-up based on interocular differences. RESULTS: The 50 included patients had on average 16.9 μm peripapillary retinal nerve fiber layer loss, 10.6 μm ganglion cell and inner plexiform layer (GCIP) loss, and an average HCVA decrease of 0.22 dec. Based on a linear regression model, average GCIP loss amounted to -0.2 μm per day and started 8 days after onset. OCT outcomes but not VEP correlated well with all visual function measurements at follow-up. Structural and functional damage in 20 patients (40%) diagnosed de novo with multiple sclerosis (MS) and in 2 patients (4%) with positive myelin oligodendrocyte glycoprotein antibodies (MOG-IgG) test did not differ from patients with idiopathic ON. CONCLUSIONS:Optic neuritis causes substantial retinal damage and vision loss independent of the underlying disease. Our study supports that GCIP damage starts closely to clinical onset. Good structure-function correlations between OCT and vision support the importance of OCT in monitoring acute ON.
Authors: Nic Skorupka; Andrei Miclea; Katarzyna Aleksandra Jalowiec; Christoph Bocksrucker; Nicole Kamber; Andrew Chan; Behrouz Mansouri Taleghani; Robert Hoepner; Anke Salmen Journal: Transfus Med Hemother Date: 2019-11-14 Impact factor: 3.747
Authors: Christian Albert; Janine Mikolajczak; Anja Liekfeld; Sophie K Piper; Michael Scheel; Hanna G Zimmermann; Claus Nowak; Jan Dörr; Judith Bellmann-Strobl; Claudia Chien; Alexander U Brandt; Friedemann Paul; Olaf Hoffmann Journal: BMC Neurol Date: 2020-03-03 Impact factor: 2.474
Authors: Lilian Aly; Christina Noll; Rebecca Wicklein; Elisabeth Wolf; Eva Feodora Romahn; Josphine Wauschkuhn; Sami Hosari; Christian Mardin; Achim Berthele; Bernhard Hemmer; Thomas Korn; Benjamin Knier Journal: Neurol Neuroimmunol Neuroinflamm Date: 2022-03-17
Authors: Alexander U Brandt; Friedemann Paul; Svenja Specovius; Hanna G Zimmermann; Frederike Cosima Oertel; Claudia Chien; Charlotte Bereuter; Lawrence J Cook; Marco Aurélio Lana Peixoto; Mariana Andrade Fontenelle; Ho Jin Kim; Jae-Won Hyun; Su-Kyung Jung; Jacqueline Palace; Adriana Roca-Fernandez; Alejandro Rubio Diaz; Maria Isabel Leite; Srilakshmi M Sharma; Fereshte Ashtari; Rahele Kafieh; Alireza Dehghani; Mohsen Pourazizi; Lekha Pandit; Anitha Dcunha; Orhan Aktas; Marius Ringelstein; Philipp Albrecht; Eugene May; Caryl Tongco; Letizia Leocani; Marco Pisa; Marta Radaelli; Elena H Martinez-Lapiscina; Hadas Stiebel-Kalish; Mark Hellmann; Itay Lotan; Sasitorn Siritho; Jérôme de Seze; Thomas Senger; Joachim Havla; Romain Marignier; Caroline Tilikete; Alvaro Cobo Calvo; Denis Bernardi Bichuetti; Ivan Maynart Tavares; Nasrin Asgari; Kerstin Soelberg; Ayse Altintas; Rengin Yildirim; Uygur Tanriverdi; Anu Jacob; Saif Huda; Zoe Rimler; Allyson Reid; Yang Mao-Draayer; Ibis Soto de Castillo; Michael R Yeaman; Terry J Smith Journal: BMJ Open Date: 2020-10-29 Impact factor: 2.692