Literature DB >> 30108758

Synthesis, antioxidant and antitumoral activities of 5'-arylchalcogeno-3-aminothymidine (ACAT) derivatives.

Raquel Mello da Rosa1, Bruna Candia Piccoli2, Fernanda D'Avila da Silva2, Luciano Dornelles1, João B T Rocha2, Mariana Souza Sonego3, Karine Rech Begnini3, Tiago Collares3, Fabiana K Seixas3, Oscar E D Rodrigues1.   

Abstract

This article presents the preparation and in vitro biological activities of new 5'-arylchalcogeno-3-aminothymidine derivatives as antioxidants (inhibition of lipid peroxidation, scavenging of the free radical 2,2-diphenylpicrylhydrazyl and demonstration of a thiol peroxidase-like activity) as well as antitumoral agents against bladder carcinoma 5637. The chalcogeno-aminothymidines presented prominent activity in the tests for both biological properties, showing a direct relation with the chalcogenium atom.

Entities:  

Year:  2016        PMID： 30108758      PMCID： PMC6071852          DOI： 10.1039/c6md00640j

Source DB:  PubMed          Journal:  Medchemcomm        ISSN： 2040-2503            Impact factor:   3.597


  21 in total

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  4 in total

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2.  Hepatic effect of sofosbuvir and daclatasvir in thioacetamide-induced liver injury in rats.

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  4 in total

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