Anna M Dinkla1, Jelmer M Wolterink2, Matteo Maspero3, Mark H F Savenije4, Joost J C Verhoeff4, Enrica Seravalli4, Ivana Išgum2, Peter R Seevinck2, Cornelis A T van den Berg4. 1. Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, The Netherlands. Electronic address: a.m.dinkla@umcutrecht.nl. 2. Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands. 3. Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, The Netherlands; Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands. 4. Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, The Netherlands.
Abstract
PURPOSE: This work aims to facilitate a fast magnetic resonance (MR)-only workflow for radiation therapy of intracranial tumors. Here, we evaluate whether synthetic computed tomography (sCT) images generated with a dilated convolutional neural network (CNN) enable accurate MR-based dose calculations in the brain. METHODS AND MATERIALS: We conducted a retrospective study of 52 patients with brain tumors who underwent both computed tomography (CT) and MR imaging for radiation therapy treatment planning. To generate the sCTs, a T1-weighted gradient echo MR sequence was selected from the clinical protocol for multiple types of brain tumors. sCTs were created for all 52 patients with a dilated CNN using 2-fold cross validation; in each fold, 26 patients were used for training and the remaining 26 patients were used for evaluation. For each patient, the clinical CT-based treatment plan was recalculated on sCT. We calculated dose differences and gamma pass rates between CT- and sCT-based plans inside body and planning target volume. Geometric fidelity of the sCT and differences in beam depth and equivalent path length were assessed between both treatment plans. RESULTS: sCT generation took 1 minute per patient. Over the patient population, the mean absolute error of the sCT within the intersection of body contours was 67 ± 11 HU (±1 standard deviation [SD], range: 51-117 HU), and the mean error was 13 ± 9 HU (±1 SD, range: -2 to 38 HU). Dosimetric analysis showed mean deviations of 0.00% ± 0.02% (±1 SD, range: -0.05 to 0.03) for dose within the body contours and -0.13% ± 0.39% (±1 SD, range: -1.43 to 0.80) inside the planning target volume. Mean γ1mm/1% was 98.8% ± 2.2% for doses >50% of the prescribed dose. CONCLUSIONS: The presented dilated CNN generated sCTs from conventional MR images without adding scan time to the acquisition. Dosimetric evaluation suggests that dose calculations performed on the sCTs are accurate and can therefore be used for MR-only intracranial radiation therapy treatment planning.
PURPOSE: This work aims to facilitate a fast magnetic resonance (MR)-only workflow for radiation therapy of intracranial tumors. Here, we evaluate whether synthetic computed tomography (sCT) images generated with a dilated convolutional neural network (CNN) enable accurate MR-based dose calculations in the brain. METHODS AND MATERIALS: We conducted a retrospective study of 52 patients with brain tumors who underwent both computed tomography (CT) and MR imaging for radiation therapy treatment planning. To generate the sCTs, a T1-weighted gradient echo MR sequence was selected from the clinical protocol for multiple types of brain tumors. sCTs were created for all 52 patients with a dilated CNN using 2-fold cross validation; in each fold, 26 patients were used for training and the remaining 26 patients were used for evaluation. For each patient, the clinical CT-based treatment plan was recalculated on sCT. We calculated dose differences and gamma pass rates between CT- and sCT-based plans inside body and planning target volume. Geometric fidelity of the sCT and differences in beam depth and equivalent path length were assessed between both treatment plans. RESULTS: sCT generation took 1 minute per patient. Over the patient population, the mean absolute error of the sCT within the intersection of body contours was 67 ± 11 HU (±1 standard deviation [SD], range: 51-117 HU), and the mean error was 13 ± 9 HU (±1 SD, range: -2 to 38 HU). Dosimetric analysis showed mean deviations of 0.00% ± 0.02% (±1 SD, range: -0.05 to 0.03) for dose within the body contours and -0.13% ± 0.39% (±1 SD, range: -1.43 to 0.80) inside the planning target volume. Mean γ1mm/1% was 98.8% ± 2.2% for doses >50% of the prescribed dose. CONCLUSIONS: The presented dilated CNN generated sCTs from conventional MR images without adding scan time to the acquisition. Dosimetric evaluation suggests that dose calculations performed on the sCTs are accurate and can therefore be used for MR-only intracranial radiation therapy treatment planning.
Authors: P Su; S Guo; S Roys; F Maier; H Bhat; E R Melhem; D Gandhi; R P Gullapalli; J Zhuo Journal: AJNR Am J Neuroradiol Date: 2020-09-03 Impact factor: 3.825
Authors: Elizabeth Huynh; Ahmed Hosny; Christian Guthier; Danielle S Bitterman; Steven F Petit; Daphne A Haas-Kogan; Benjamin Kann; Hugo J W L Aerts; Raymond H Mak Journal: Nat Rev Clin Oncol Date: 2020-08-25 Impact factor: 66.675
Authors: Samaneh Kazemifar; Ana M Barragán Montero; Kevin Souris; Sara T Rivas; Robert Timmerman; Yang K Park; Steve Jiang; Xavier Geets; Edmond Sterpin; Amir Owrangi Journal: J Appl Clin Med Phys Date: 2020-03-26 Impact factor: 2.102
Authors: Ghazal Shafai-Erfani; Yang Lei; Yingzi Liu; Yinan Wang; Tonghe Wang; Jim Zhong; Tian Liu; Mark McDonald; Walter J Curran; Jun Zhou; Hui-Kuo Shu; Xiaofeng Yang Journal: Int J Part Ther Date: 2019-09-30