Lucas A Torres1, Jayme R Vianna1, Faisal Jarrar1, Glen P Sharpe1, Makoto Araie2, Joseph Caprioli3, Shaban Demirel4, Christopher A Girkin5, Masanori Hangai6, Aiko Iwase7, Jeffrey M Liebmann8, Christian Y Mardin9, Toru Nakazawa10, Harry A Quigley11, Alexander F Scheuerle12, Kazuhisa Sugiyama13, Hidenobu Tanihara14, Goji Tomita15, Yasuo Yanagi16, Claude F Burgoyne4, Balwantray C Chauhan1. 1. Department of Ophthalmology and Visual Sciences, Dalhousie University, Halifax, Nova Scotia, Canada. 2. Kanto Central Hospital of the Mutual Aid Association of Public School Teachers, Tokyo, Japan. 3. Department of Ophthalmology, Jules Stein Eye Institute, University of California Los Angeles, Los Angeles, California, USA. 4. Devers Eye Institute, Legacy Research Institute, Portland, Oregon, USA. 5. Department of Ophthalmology, University of Alabama at Birmingham, Birmingham, Alabama, USA. 6. Department of Ophthalmology, Saitama Medical School, Moro, Japan. 7. Tajimi Iwase Eye Clinic, Tajimi, Japan. 8. New York Eye and Ear Infirmary, New York University School of Medicine, New York, New York, USA. 9. Department of Ophthalmology, University of Erlangen, Erlangen, Germany. 10. Department of Ophthalmology, Tohoku University Graduate School of Medicine, Tohoku, Japan. 11. Wilmer Ophthalmological Institute, Johns Hopkins University, Baltimore, Maryland, USA. 12. Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany. 13. Department of Ophthalmology and Visual Science, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan. 14. Department of Ophthalmology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan. 15. Department of Ophthalmology, Toho University Ohashi Medical Center, Tokyo, Japan. 16. Department of Ophthalmology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan.
Abstract
PURPOSE: To determine the frequency with which retinal tissues other than the nerve fibre layer, hereafter referred to as protruded retinal layers (PRL), are a component of optical coherence tomography (OCT) neuroretinal rim measurements. METHODS: Ninety healthy (30 White, Black and Japanese, respectively) subjects were included in the study. A radial scan pattern (24 B-scans centred on Bruch's membrane opening [BMO]) was used. For each of the 48 minimum rim width (MRW) measurement points, we determined whether PRL were present, absent or indeterminate. When present, the proportion of PRL within the MRW was quantified. RESULTS: Protruded retinal layers were present in 503 (11.6%), absent in 3805 (88.1%) and indeterminate in 12 (0.3%) measurement points. Overall, 69 (76.6%) subjects had ≥1 points with PRL, with White subjects having the highest frequency and Japanese the lowest (29 [97%] and 18 [60%], respectively; p < 0.01). PRL were present in one-third of points in the temporal sector, but ≤5% in other sectors. When present, the median PRL thickness was 53.0 (interquartile range [IQR]: 33.0 to 78.5) μm, representing 20.6 (IQR: 13.0 to 28.5)% of MRW. Globally, the median PRL thickness comprised 1.3 (IQR: 0.2 to 3.5)% of the MRW; however, in the temporal sector, it exceeded 30% of MRW in some subjects. CONCLUSIONS: Protruded retinal layers are a component of MRW measurements in most normal subjects, occurring in almost 12% of all measurement points analysed. There were racial variations in the presence of PRL and a significantly higher frequency of PRL in the temporal sector.
PURPOSE: To determine the frequency with which retinal tissues other than the nerve fibre layer, hereafter referred to as protruded retinal layers (PRL), are a component of optical coherence tomography (OCT) neuroretinalrim measurements. METHODS: Ninety healthy (30 White, Black and Japanese, respectively) subjects were included in the study. A radial scan pattern (24 B-scans centred on Bruch's membrane opening [BMO]) was used. For each of the 48 minimum rim width (MRW) measurement points, we determined whether PRL were present, absent or indeterminate. When present, the proportion of PRL within the MRW was quantified. RESULTS: Protruded retinal layers were present in 503 (11.6%), absent in 3805 (88.1%) and indeterminate in 12 (0.3%) measurement points. Overall, 69 (76.6%) subjects had ≥1 points with PRL, with White subjects having the highest frequency and Japanese the lowest (29 [97%] and 18 [60%], respectively; p < 0.01). PRL were present in one-third of points in the temporal sector, but ≤5% in other sectors. When present, the median PRL thickness was 53.0 (interquartile range [IQR]: 33.0 to 78.5) μm, representing 20.6 (IQR: 13.0 to 28.5)% of MRW. Globally, the median PRL thickness comprised 1.3 (IQR: 0.2 to 3.5)% of the MRW; however, in the temporal sector, it exceeded 30% of MRW in some subjects. CONCLUSIONS: Protruded retinal layers are a component of MRW measurements in most normal subjects, occurring in almost 12% of all measurement points analysed. There were racial variations in the presence of PRL and a significantly higher frequency of PRL in the temporal sector.
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