Emre Umucu1, Mary Wyman2,3, Beatrice Lee4, Megan Zuelsdorff5, Susan Flowers Benton6, Naomi Nystrom2, Sterling C Johnson2,7,8,9, Cynthia M Carlsson2,7,8,9, Sanjay Asthana2,7,8,9, Carey E Gleason2,7,8. 1. 1 Department of Rehabilitation Sciences, University of Texas at El Paso, El Paso, TX, USA. 2. 2 Geriatric Research, Education and Clinical Center, W. S. Middleton Memorial Veterans Hospital, Madison, WI, USA. 3. 3 University of Wisconsin Madison School of Medicine and Public Health, Madison, WI, USA. 4. 4 Department of Rehabilitation Psychology and Special Education, University of Wisconsin-Madison, Madison, WI, USA. 5. 5 Center for Demography of Health and Aging, University of Wisconsin-Madison, Madison, WI, USA. 6. 6 Department of Family Medicine and Community Health, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA. 7. 7 Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA. 8. 8 Division of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA. 9. 9 Department of Medicine, Wisconsin Alzheimer's Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Abstract
OBJECTIVES: The purpose of the present study was to validate the Apathy Evaluation Scale, self-rated version (AES-S), and assess the severity of apathy in a cognitively healthy middle-aged cohort at risk for Alzheimer's disease (AD). METHOD: Three hundred and sixteen middle-aged adults were selected to represent a subset of the Wisconsin Alzheimer's Disease Research Center Clinical Core: the Investigating Memory in People At-risk, Causes and Treatments cohort. RESULTS: An exploratory factor analysis (EFA) with varimax rotation identified 3 subscales: apathy, disinterest, and social withdrawal factors. Confirmatory factor analysis confirmed the EFA findings. Results indicated acceptable convergent and discriminant validity. The AES-S is a reliable instrument to quantify apathy in cognitively healthy middle-aged individuals at risk for AD. DISCUSSION: This study demonstrates the AES-S is a psychometrically sound measurement tool for assessing levels of apathy in a cognitively healthy middle-aged cohort at risk for AD.
OBJECTIVES: The purpose of the present study was to validate the Apathy Evaluation Scale, self-rated version (AES-S), and assess the severity of apathy in a cognitively healthy middle-aged cohort at risk for Alzheimer's disease (AD). METHOD: Three hundred and sixteen middle-aged adults were selected to represent a subset of the Wisconsin Alzheimer's Disease Research Center Clinical Core: the Investigating Memory in People At-risk, Causes and Treatments cohort. RESULTS: An exploratory factor analysis (EFA) with varimax rotation identified 3 subscales: apathy, disinterest, and social withdrawal factors. Confirmatory factor analysis confirmed the EFA findings. Results indicated acceptable convergent and discriminant validity. The AES-S is a reliable instrument to quantify apathy in cognitively healthy middle-aged individuals at risk for AD. DISCUSSION: This study demonstrates the AES-S is a psychometrically sound measurement tool for assessing levels of apathy in a cognitively healthy middle-aged cohort at risk for AD.
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