Shefali Chaudhary1, Simon Zhornitsky1, Herta H Chao2,3, Christopher H van Dyck1,4,5, Chiang-Shan R Li1,4,5,6. 1. Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA. 2. Comprehensive Cancer Center, Department of Medicine, Yale University School of Medicine, New Haven, CT, USA. 3. Cancer Center, VA Connecticut Healthcare System, West Haven, CT, USA. 4. Department of Neuroscience, Yale University School of Medicine, New Haven, CT, USA. 5. Interdepartmental Neuroscience Program, Yale University School of Medicine, New Haven, CT, USA. 6. Wu Tsai Institute, Yale University, New Haven, CT, USA.
Abstract
BACKGROUND: Affecting nearly half of the patients with Alzheimer's disease (AD), apathy is associated with higher morbidity and reduced quality of life. Basal ganglia and cortical atrophy have been implicated in apathy. However, the findings have varied across studies and left unclear whether subdomains of apathy may involve distinct neuroanatomical correlates. OBJECTIVE: To identify neuroanatomical correlates of AD-associated apathy. METHODS: We performed a meta-analysis and label-based review of the literature. Further, following published routines of voxel-based morphometry, we aimed to confirm the findings in an independent cohort of 19 patients with AD/mild cognitive impairment and 25 healthy controls assessed with the Apathy Evaluation Scale. RESULTS: Meta-analysis of 167 AD and 56 healthy controls showed convergence toward smaller basal ganglia gray matter volume (GMV) in apathy. Label-based review showed anterior cingulate, putamen, insula, inferior frontal gyrus (IFG) and middle temporal gyrus (MTG) atrophy in AD apathy. In the independent cohort, with small-volume-correction, right putamen and MTG showed GMVs in negative correlation with Apathy Evaluation Scale total, behavioral, and emotional scores, and right IFG with emotional score (p < 0.05 family-wise error (FWE)-corrected), controlling for age, education, intracranial volume, and depression. With the Mini-Mental State Examination scores included as an additional covariate, the correlation of right putamen GMV with behavioral and emotional score, right MTG GMV with total and emotional score, and right IFG GMV with emotional score were significant. CONCLUSION: The findings implicate putamen, MTG and IFG atrophy in AD associated apathy, potentially independent of cognitive impairment and depression, and suggest potentially distinct volumetric correlates of apathy.
BACKGROUND: Affecting nearly half of the patients with Alzheimer's disease (AD), apathy is associated with higher morbidity and reduced quality of life. Basal ganglia and cortical atrophy have been implicated in apathy. However, the findings have varied across studies and left unclear whether subdomains of apathy may involve distinct neuroanatomical correlates. OBJECTIVE: To identify neuroanatomical correlates of AD-associated apathy. METHODS: We performed a meta-analysis and label-based review of the literature. Further, following published routines of voxel-based morphometry, we aimed to confirm the findings in an independent cohort of 19 patients with AD/mild cognitive impairment and 25 healthy controls assessed with the Apathy Evaluation Scale. RESULTS: Meta-analysis of 167 AD and 56 healthy controls showed convergence toward smaller basal ganglia gray matter volume (GMV) in apathy. Label-based review showed anterior cingulate, putamen, insula, inferior frontal gyrus (IFG) and middle temporal gyrus (MTG) atrophy in AD apathy. In the independent cohort, with small-volume-correction, right putamen and MTG showed GMVs in negative correlation with Apathy Evaluation Scale total, behavioral, and emotional scores, and right IFG with emotional score (p < 0.05 family-wise error (FWE)-corrected), controlling for age, education, intracranial volume, and depression. With the Mini-Mental State Examination scores included as an additional covariate, the correlation of right putamen GMV with behavioral and emotional score, right MTG GMV with total and emotional score, and right IFG GMV with emotional score were significant. CONCLUSION: The findings implicate putamen, MTG and IFG atrophy in AD associated apathy, potentially independent of cognitive impairment and depression, and suggest potentially distinct volumetric correlates of apathy.
Authors: Leonie C P Banning; Inez H G B Ramakers; Sebastian Köhler; Esther E Bron; Frans R J Verhey; Peter Paul de Deyn; Jurgen A H R Claassen; Huiberdina L Koek; Huub A M Middelkoop; Wiesje M van der Flier; Aad van der Lugt; Pauline Aalten Journal: Am J Geriatr Psychiatry Date: 2020-02-20 Impact factor: 4.105
Authors: Shefali Chaudhary; Simon Zhornitsky; Alicia Roy; Christine Summers; Tim Ahles; Chiang-Shan R Li; Herta H Chao Journal: Cancer Med Date: 2022-03-22 Impact factor: 4.711