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Literature DB >> 30101676

The Osteoinductive Effect of Controlled Bone Morphogenic Protein 2 Release Is Location Dependent.

Maurits G L Olthof^1,2,3,4,5, Lichun Lu^2,3, Marianna A Tryfonidou⁴, Loek D Loozen¹, Behdad Pouran^1,6, Michael J Yaszemski^2,3, Björn P Meij⁴, Wouter J A Dhert^1,4, Jacqueline Alblas¹, Diederik H R Kempen⁷.

Abstract

IMPACT STATEMENT: The main challenge in bone morphogenic protein 2 (BMP-2)-based application lies in finding strategies to prolong its biologic activity as it has a short biological half-life. The present study uses a phosphate-modified oligo[(polyethylene glycol) fumarate] hydrogel that can be tuned to achieve differential release profiles of biologically active BMP-2 release. We demonstrate that this platform outperforms Infuse®, currently used in the clinic and that the osteoinductive effect of BMP-2 is location dependent. Altogether, this study stresses the importance of evaluating efficacy of bone tissue engineering strategies at an orthotopic location rather than subcutaneously. Even more so, it emphasizes the role of biomaterials as a scaffold to achieve proper bone tissue engineering.

Entities: Chemical Gene

Keywords: application sites; bone morphogenetic protein 2; bone tissue engineering; oligo[(polyethylene glycol) fumarate]

Mesh：

Substances：

Year: 2019 PMID： 30101676 PMCID： PMC6388716 DOI： 10.1089/ten.TEA.2017.0427

Source DB: PubMed Journal: Tissue Eng Part A ISSN： 1937-3341 Impact factor: 3.845

32 in total

1. Incorporation of phosphate group modulates bone cell attachment and differentiation on oligo(polyethylene glycol) fumarate hydrogel.

Authors: Mahrokh Dadsetan; Melissa Giuliani; Florian Wanivenhaus; M Brett Runge; Jon E Charlesworth; Michael J Yaszemski
Journal: Acta Biomater Date: 2012-01-08 Impact factor: 8.947

2. The control of human mesenchymal cell differentiation using nanoscale symmetry and disorder.

Authors: Matthew J Dalby; Nikolaj Gadegaard; Rahul Tare; Abhay Andar; Mathis O Riehle; Pawel Herzyk; Chris D W Wilkinson; Richard O C Oreffo
Journal: Nat Mater Date: 2007-09-23 Impact factor: 43.841

Review 3. Improving protein therapeutics with sustained-release formulations.

Authors: S D Putney; P A Burke
Journal: Nat Biotechnol Date: 1998-02 Impact factor: 54.908

4. The stem cell potential and multipotency of human adipose tissue-derived stem cells vary by cell donor and are different from those of other types of stem cells.

Authors: Hyun Jin Yang; Ki-Joo Kim; Min Kyoung Kim; Su Jin Lee; Yeon Hee Ryu; Bommie F Seo; Deuk-Young Oh; Sang-Tae Ahn; Hee Young Lee; Jong Won Rhie
Journal: Cells Tissues Organs Date: 2015-03-25 Impact factor: 2.481

5. The effect of ethylene glycol methacrylate phosphate in PEG hydrogels on mineralization and viability of encapsulated hMSCs.

Authors: Charles R Nuttelman; Danielle S W Benoit; Margaret C Tripodi; Kristi S Anseth
Journal: Biomaterials Date: 2005-09-01 Impact factor: 12.479

3. Myokine Irisin promotes osteogenesis by activating BMP/SMAD signaling via αV integrin and regulates bone mass in mice.

Authors: Yuan Xue; Sihan Hu; Chichi Chen; Jiachen He; Jie Sun; Yesheng Jin; Yuanshu Zhang; Guoqing Zhu; Qin Shi; Yongjun Rui
Journal: Int J Biol Sci Date: 2022-01-01 Impact factor: 6.580

3 in total

The Osteoinductive Effect of Controlled Bone Morphogenic Protein 2 Release Is Location Dependent.

1. Incorporation of phosphate group modulates bone cell attachment and differentiation on oligo(polyethylene glycol) fumarate hydrogel.

2. The control of human mesenchymal cell differentiation using nanoscale symmetry and disorder.

Review 3. Improving protein therapeutics with sustained-release formulations.

4. The stem cell potential and multipotency of human adipose tissue-derived stem cells vary by cell donor and are different from those of other types of stem cells.

5. The effect of ethylene glycol methacrylate phosphate in PEG hydrogels on mineralization and viability of encapsulated hMSCs.

6. Effect of local sequential VEGF and BMP-2 delivery on ectopic and orthotopic bone regeneration.

7. Adipose-derived stem cell: a better stem cell than BMSC.

8. Controlled release by biodegradable hydrogels enhances the ectopic bone formation of bone morphogenetic protein.

9. BMP-2 release and dose-response studies in hydroxyapatite and beta-tricalcium phosphate.

10. Yield of human adipose-derived adult stem cells from liposuction aspirates.

1. Effect of Biomaterial Electrical Charge on Bone Morphogenetic Protein-2-Induced In Vivo Bone Formation.

2. Recapitulation of growth factor-enriched microenvironment via BMP receptor activating hydrogel.

3. Myokine Irisin promotes osteogenesis by activating BMP/SMAD signaling via αV integrin and regulates bone mass in mice.