Isabelle Mosnier1,2, Antoine Vanier3,4, Damien Bonnard5, Geneviève Lina-Granade5, Eric Truy6,7, Philippe Bordure8, Benoit Godey9, Mathieu Marx10, Emmanuel Lescanne11, Frédéric Venail12, Christine Poncet13, Olivier Sterkers1,2, Joël Belmin14. 1. Unité Réhabilitation Chirurgicale Mini-Invasive et Robotisée de l'Audition, INSERM, Sorbonne Université, Paris, France. 2. Service ORL, Otologie, Implants Auditifs et Chirurgie de la Base du Crâne, AP-HP, GHU Pitié-Salpêtrière, Paris, France. 3. Département de Santé Publique, Sorbonne Université, Paris, France. 4. Département de Biostatistique, Santé Publique et Informatique Médicale, AP-HP, GHU Pitié-Salpêtrière, Paris, France. 5. Lyon Neuroscience Research Center, Brain Dynamics and Cognition Team, CRNL, INSERM U1028, CNRS UMR5292, Lyon, F-69000, France. 6. Service ORL, Hôpital Pellegrin, Bordeaux, France. 7. Service ORL, Hôpital Edouard Herriot, Lyon, France. 8. Service ORL, Hôpital Hôtel Dieu, Nantes, France. 9. Service ORL, Hôpital Pontchailloux, Rennes, France. 10. Service ORL, Hôpital Purpan, Toulouse, France. 11. Service ORL, Hôpital Bretonneau, Tours, France. 12. Service ORL, Hôpital Gui de Chauliac, Montpellier, France. 13. Service ORL APHP, Hôpital Rothschild, Paris, France. 14. Service de Gériatrie et Sorbonne Université AP-HP, Hôpital Charles Foix, Ivry-sur-Seine, France.
Abstract
OBJECTIVES: To analyze long-term cognitive status and function after cochlear implantation in profoundly deaf individuals. DESIGN: Prospective observational longitudinal study. SETTING: Ten academic medical centers referent for cochlear implantation. PARTICIPANTS: Individuals aged 65 and older who qualified for cochlear implantation (N=70). MEASUREMENTS: Cognitive tests were administered before cochlear implantation and 1 and 5 or more years after cochlear implantation. Evaluation consisted of 6 tests assessing attention, memory, orientation, executive function, mental flexibility, and fluency. Cognitive status was determined as normal, mild cognitive impairment (MCI), or dementia. Speech perception in quiet and noisy conditions was assessed using disyllabic words, and quality of life was assessed using the Nijmegen Cochlear Implant Questionnaire. RESULTS: Mean follow-up was 6.8 years (range 5.5-8.5 years). Speech perception scores and quality of life remained stable from 1 to 7 years after cochlear implantation. Of 31 participants (45%) with MCI before cochlear implantation, 2 (6%) developed dementia during follow-up, 19 (61%) remained stable, and 10 (32%) returned to normal cognition. None of the 38 with normal cognition developed dementia during follow-up, although 12 (32%) developed MCI. CONCLUSION: MCI is highly prevalent in older adults with profound hearing loss. Nevertheless, we observed a low rate of progression to dementia, and cognitive function improved in some individuals with MCI at baseline. These results highlight that cochlear implantation should be strongly considered in profoundly deaf individuals, even those with MCI, who may have a specific subtype of MCI, with a possible positive effect of hearing rehabilitation on neurocognitive functioning.
OBJECTIVES: To analyze long-term cognitive status and function after cochlear implantation in profoundly deaf individuals. DESIGN: Prospective observational longitudinal study. SETTING: Ten academic medical centers referent for cochlear implantation. PARTICIPANTS: Individuals aged 65 and older who qualified for cochlear implantation (N=70). MEASUREMENTS: Cognitive tests were administered before cochlear implantation and 1 and 5 or more years after cochlear implantation. Evaluation consisted of 6 tests assessing attention, memory, orientation, executive function, mental flexibility, and fluency. Cognitive status was determined as normal, mild cognitive impairment (MCI), or dementia. Speech perception in quiet and noisy conditions was assessed using disyllabic words, and quality of life was assessed using the Nijmegen Cochlear Implant Questionnaire. RESULTS: Mean follow-up was 6.8 years (range 5.5-8.5 years). Speech perception scores and quality of life remained stable from 1 to 7 years after cochlear implantation. Of 31 participants (45%) with MCI before cochlear implantation, 2 (6%) developed dementia during follow-up, 19 (61%) remained stable, and 10 (32%) returned to normal cognition. None of the 38 with normal cognition developed dementia during follow-up, although 12 (32%) developed MCI. CONCLUSION: MCI is highly prevalent in older adults with profound hearing loss. Nevertheless, we observed a low rate of progression to dementia, and cognitive function improved in some individuals with MCI at baseline. These results highlight that cochlear implantation should be strongly considered in profoundly deaf individuals, even those with MCI, who may have a specific subtype of MCI, with a possible positive effect of hearing rehabilitation on neurocognitive functioning.
Authors: Daniel Newsted; Emily Rosen; Bonnie Cooke; Michael M Beyea; Matthew T W Simpson; Jason A Beyea Journal: Can Fam Physician Date: 2020-11 Impact factor: 3.275
Authors: Daniel Newsted; Emily Rosen; Bonnie Cooke; Michael M Beyea; Matthew T W Simpson; Jason A Beyea Journal: Can Fam Physician Date: 2020-11 Impact factor: 3.275
Authors: Ahmet M Tekin; Marco Matulic; Wim Wuyts; Masoud Zoka Assadi; Griet Mertens; Vincent van Rompaey; Yongxin Li; Paul van de Heyning; Vedat Topsakal Journal: Genes (Basel) Date: 2021-04-21 Impact factor: 4.096
Authors: Ellen Andries; Annick Gilles; Vedat Topsakal; Olivier Vanderveken; Paul Van de Heyning; Vincent Van Rompaey; Griet Mertens Journal: Eur Arch Otorhinolaryngol Date: 2021-03-08 Impact factor: 2.503