Literature DB >> 30090408

A 7-methoxytacrine-4-pyridinealdoxime hybrid as a novel prophylactic agent with reactivation properties in organophosphate intoxication.

E Nepovimova1, J Korabecny1, R Dolezal1, T D Nguyen1, D Jun1,2, O Soukup1, M Pasdiorova1, P Jost1, L Muckova2, D Malinak1, L Gorecki1, K Musilek1, Kamil Kuca1.   

Abstract

Chemical warfare agents constitute an increasing threat to both military and civilian populations. Therefore, effective prophylactic approaches are urgently needed. Herein, we present a novel hybrid compound which is able not only to keep acetylcholinesterase resistant to organophosphate (OP) inhibitors, but also to serve as an enzyme reactivator in the case of OP intoxication.

Entities:  

Year:  2016        PMID： 30090408      PMCID： PMC6062411          DOI： 10.1039/c6tx00130k

Source DB:  PubMed          Journal:  Toxicol Res (Camb)        ISSN： 2045-452X            Impact factor:   3.524


  20 in total

1.  Prophylaxis and post-exposure treatment of intoxications caused by nerve agents and organophosphorus pesticides.

Authors:  Kamil Kuca; Daniel Jun; Kamil Musilek; Miroslav Pohanka; Jana Zdarova Karasova; Ondrej Soukup
Journal:  Mini Rev Med Chem       Date:  2013-12       Impact factor: 3.862

2.  Pharmacokinetics of obidoxime in patients poisoned with organophosphorus compounds.

Authors:  H Thiermann; F Eyer; N Felgenhauer; R Pfab; T Zilker; P Eyer; F Worek
Journal:  Toxicol Lett       Date:  2010-06-11       Impact factor: 4.372

3.  Protective effect of 9-amino-7-methoxy-1,2,3,4-tetra-hydroacridine against inhibition of acetylcholinesterase by O-ethyl s-(2-dimethylaminoethyl) methylphosphonotioate in vivo.

Authors:  J Bajgar; J Fusek; J Patocka; V Hrdina
Journal:  Arch Toxicol       Date:  1983-10       Impact factor: 5.153

4.  7-MEOTA-donepezil like compounds as cholinesterase inhibitors: Synthesis, pharmacological evaluation, molecular modeling and QSAR studies.

Authors:  Jan Korabecny; Rafael Dolezal; Pavla Cabelova; Anna Horova; Eva Hruba; Jan Ricny; Lukas Sedlacek; Eugenie Nepovimova; Katarina Spilovska; Martin Andrs; Kamil Musilek; Veronika Opletalova; Vendula Sepsova; Daniela Ripova; Kamil Kuca
Journal:  Eur J Med Chem       Date:  2014-05-27       Impact factor: 6.514

5.  Mono-oxime bisquaternary acetylcholinesterase reactivators with prop-1,3-diyl linkage-Preparation, in vitro screening and molecular docking.

Authors:  Kamil Musilek; Marketa Komloova; Ondrej Holas; Anna Horova; Miroslav Pohanka; Frank Gunn-Moore; Vlastimil Dohnal; Martin Dolezal; Kamil Kuca
Journal:  Bioorg Med Chem       Date:  2010-12-16       Impact factor: 3.641

6.  A resurrection of 7-MEOTA: a comparison with tacrine.

Authors:  Ondrej Soukup; Daniel Jun; Jana Zdarova-Karasova; Jiri Patocka; Kamil Musilek; Jan Korabecny; Jan Krusek; Martina Kaniakova; Vendula Sepsova; Jana Mandikova; Frantisek Trejtnar; Miroslav Pohanka; Lucie Drtinova; Michal Pavlik; Gunnar Tobin; Kamil Kuca
Journal:  Curr Alzheimer Res       Date:  2013-10       Impact factor: 3.498

7.  Pralidoxime iodide (2-pAM) penetrates across the blood-brain barrier.

Authors:  Koichi Sakurada; Kazuo Matsubara; Keiko Shimizu; Hiroshi Shiono; Yasuo Seto; Koichiro Tsuge; Mineo Yoshino; Ikuko Sakai; Harutaka Mukoyama; Takehiko Takatori
Journal:  Neurochem Res       Date:  2003-09       Impact factor: 3.996

Review 8.  Structural requirements of acetylcholinesterase reactivators.

Authors:  Kamil Kuca; Daniel Juna; Kamil Musilek
Journal:  Mini Rev Med Chem       Date:  2006-03       Impact factor: 3.862

Review 9.  Chemical aspects of pharmacological prophylaxis against nerve agent poisoning.

Authors:  Jiri Bajgar; Josef Fusek; Jiri Kassa; Kamil Kuca; Daniel Jun
Journal:  Curr Med Chem       Date:  2009       Impact factor: 4.530

10.  Acetylcholinesterases--the structural similarities and differences.

Authors:  Jirí Wiesner; Zdenek Kriz; Kamil Kuca; Daniel Jun; Jaroslav Koca
Journal:  J Enzyme Inhib Med Chem       Date:  2007-08       Impact factor: 5.051
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  6 in total

1.  Synthesis, Biological Evaluation, and Docking Studies of Novel Bisquaternary Aldoxime Reactivators on Acetylcholinesterase and Butyrylcholinesterase Inhibited by Paraoxon.

Authors:  Kamil Kuca; Daniel Jun; Lucie Junova; Kamil Musilek; Martina Hrabinova; Jorge Alberto Valle da Silva; Teodorico Castro Ramalho; Marian Valko; Qinghua Wu; Eugenie Nepovimova; Tanos Celmar Costa França
Journal:  Molecules       Date:  2018-05-07       Impact factor: 4.411

2.  Toxic Injury to Muscle Tissue of Rats Following Acute Oximes Exposure.

Authors:  Vesna Jaćević; Eugenie Nepovimova; Kamil Kuča
Journal:  Sci Rep       Date:  2019-02-06       Impact factor: 4.379

3.  Molecular modeling studies on the interactions of 7-methoxytacrine-4-pyridinealdoxime, 4-PA, 2-PAM, and obidoxime with VX-inhibited human acetylcholinesterase: a near attack conformation approach.

Authors:  Jorge Alberto Valle da Silva; Eugenie Nepovimova; Teodorico Castro Ramalho; Kamil Kuca; Tanos Celmar Costa França
Journal:  J Enzyme Inhib Med Chem       Date:  2019-12       Impact factor: 5.051

4.  Synthesis of New Quinoline-Piperonal Hybrids as Potential Drugs against Alzheimer's Disease.

Authors:  Juliana de Oliveira C Brum; Denise Cristian F Neto; Joyce Sobreiro F D de Almeida; Josélia Alencar Lima; Kamil Kuca; Tanos Celmar C França; José D Figueroa-Villar
Journal:  Int J Mol Sci       Date:  2019-08-14       Impact factor: 5.923

5.  Design, synthesis, in silico studies and in vitro evaluation of isatin-pyridine oximes hybrids as novel acetylcholinesterase reactivators.

Authors:  Daniel A S Kitagawa; Rafael B Rodrigues; Thiago N Silva; Wellington V Dos Santos; Vinicius C V da Rocha; Joyce S F D de Almeida; Leandro B Bernardo; Taynara Carvalho-Silva; Cintia N Ferreira; Angelo A T da Silva; Alessandro B C Simas; Eugenie Nepovimova; Kamil Kuča; Tanos C C França; Samir F de A Cavalcante
Journal:  J Enzyme Inhib Med Chem       Date:  2021-12       Impact factor: 5.051

6.  Reactivation of VX-Inhibited Human Acetylcholinesterase by Deprotonated Pralidoxime. A Complementary Quantum Mechanical Study.

Authors:  Jorge Alberto Valle da Silva; Ander Francisco Pereira; Steven R LaPlante; Kamil Kuca; Teodorico Castro Ramalho; Tanos Celmar Costa França
Journal:  Biomolecules       Date:  2020-01-27
  6 in total

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