Literature DB >> 30084636

Synthesis of Quinazolin-4(3 H)-ones via the Reaction of 2-Halobenzamides with Nitriles.

Xiaoqiang Yu1, Linqi Gao1, Linan Jia1, Yoshinori Yamamoto1,2, Ming Bao1.   

Abstract

This paper describes a convenient method to synthesize quinazolin-4(3 H)-ones from simple and readily available 2-halobenzamides and nitriles. The Lewis acid Cu-catalyzed nucleophilic addition of 2-halobenzamide to nitriles followed by SNAr reaction proceeds smoothly in the presence of tBuOK as a base to produce quinazolinone derivatives.

Entities:  

Year:  2018        PMID： 30084636     DOI： 10.1021/acs.joc.8b01460

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  8 in total

1.  Rhodium-Catalyzed Merging of 2-Arylquinazolinone and 2,2-Difluorovinyl Tosylate: Diverse Synthesis of Monofluoroolefin Quinazolinone Derivatives.

Authors:  Ning Wang; Qin Yang; Zhihong Deng; Xuechun Mao; Yiyuan Peng
Journal:  ACS Omega       Date:  2020-06-15

2.  Quinazolin-4(3H)-ones and 5,6-Dihydropyrimidin-4(3H)-ones from β-Aminoamides and Orthoesters.

Authors:  Joshua T Gavin; Joel K Annor-Gyamfi; Richard A Bunce
Journal:  Molecules       Date:  2018-11-09       Impact factor: 4.411

3.  ortho-Naphthoquinone-catalyzed aerobic oxidation of amines to fused pyrimidin-4(3H)-ones: a convergent synthetic route to bouchardatine and sildenafil.

Authors:  Kyeongha Kim; Hun Young Kim; Kyungsoo Oh
Journal:  RSC Adv       Date:  2020-08-21       Impact factor: 4.036

4.  Electrochemical synthesis of quinazolinone via I2-catalyzed tandem oxidation in aqueous solution.

Authors:  Huiqing Hou; Xinhua Ma; Yingying Lin; Jin Lin; Weiming Sun; Lei Wang; Xiuzhi Xu; Fang Ke
Journal:  RSC Adv       Date:  2021-05-17       Impact factor: 4.036

5.  Preparation of Polyfunctionalized Aromatic Nitriles from Aryl Oxazolines.

Authors:  A Hess; H C Guelen; N Alandini; A Mourati; Y C Guersoy; P Knochel
Journal:  Chemistry       Date:  2021-12-02       Impact factor: 5.020

6.  Assembly of 1H-isoindole derivatives by selective carbon-nitrogen triple bond activation: access to aggregation-induced emission fluorophores for lipid droplet imaging.

Authors:  Dandan He; Zeyan Zhuang; Xu Wang; Jiawei Li; Jianxiao Li; Wanqing Wu; Zujin Zhao; Huanfeng Jiang; Ben Zhong Tang
Journal:  Chem Sci       Date:  2019-06-12       Impact factor: 9.825

7.  Synergistic catalysis on Fe-N x sites and Fe nanoparticles for efficient synthesis of quinolines and quinazolinones via oxidative coupling of amines and aldehydes.

Authors:  Zhiming Ma; Tao Song; Youzhu Yuan; Yong Yang
Journal:  Chem Sci       Date:  2019-09-23       Impact factor: 9.825

8.  Copper-Catalyzed Dual Cyclization for the Synthesis of Quinindolines.

Authors:  Hung-Kai Wang; Yu-Lun Chio; Gangaram Pallikonda; Hsyueh-Liang Wu; Haw-Lih Su; Jen-Chieh Hsieh
Journal:  Molecules       Date:  2020-11-13       Impact factor: 4.411
  8 in total

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