Beatrix Barth1,2, Kerstin Mayer-Carius3, Ute Strehl3, Augustin Kelava4, Florian Benedikt Häußinger1, Andreas Jochen Fallgatter1,5,6, Ann-Christine Ehlis1,6. 1. Psychophysiology and Optical Imaging, Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany. 2. Graduate School of Neural and Behavioral Sciences, University of Tübingen, Tübingen, Germany. 3. Institute for Medical Psychology and Behavioral Neurobiology, University of Tübingen, Tübingen, Germany. 4. Methods Center, University of Tübingen, Tübingen, Germany. 5. Werner Reichardt Centre for Integrative Neuroscience, University of Tübingen, Tübingen, Germany. 6. LEAD Graduate School & Research Network, University of Tübingen, Tübingen, Germany.
Abstract
AIM: Findings on neurophysiological alterations in attention deficit hyperactivity disorder (ADHD) have been proposed to underlie ADHD symptoms, with different etiological pathways for different patient biotypes. We aimed at determining whether neurophysiological deviations confirm distinct neurophysiological profiles in ADHD, thus providing direct evidence for the endophenotype concept. METHODS: Neurophysiological biotypes were investigated in 87 adult patients with ADHD using cluster analysis. Parameters fed into the analysis comprised both hemodynamic and electrophysiological data. To validate results, the independent variables of the clusters were compared with healthy controls. RESULTS: Cluster analysis yielded three neurophysiologically based ADHD biotypes showing: (i) above-average functioning in attention allocation; (ii) difficulties in attention allocation and inhibitory control but elevated frontal activation during a working memory task; and (iii) functional impairments in state regulation. CONCLUSION: Classifying patients with ADHD into neurophysiological biotypes sheds light on etiological pathways, with implications for diagnostics and (individualized) treatment options.
AIM: Findings on neurophysiological alterations in attention deficit hyperactivity disorder (ADHD) have been proposed to underlie ADHD symptoms, with different etiological pathways for different patient biotypes. We aimed at determining whether neurophysiological deviations confirm distinct neurophysiological profiles in ADHD, thus providing direct evidence for the endophenotype concept. METHODS: Neurophysiological biotypes were investigated in 87 adult patients with ADHD using cluster analysis. Parameters fed into the analysis comprised both hemodynamic and electrophysiological data. To validate results, the independent variables of the clusters were compared with healthy controls. RESULTS: Cluster analysis yielded three neurophysiologically based ADHD biotypes showing: (i) above-average functioning in attention allocation; (ii) difficulties in attention allocation and inhibitory control but elevated frontal activation during a working memory task; and (iii) functional impairments in state regulation. CONCLUSION: Classifying patients with ADHD into neurophysiological biotypes sheds light on etiological pathways, with implications for diagnostics and (individualized) treatment options.
Authors: Elizabeth Shephard; Emily R Stern; Odile A van den Heuvel; Daniel L C Costa; Marcelo C Batistuzzo; Priscilla B G Godoy; Antonio C Lopes; Andre R Brunoni; Marcelo Q Hoexter; Roseli G Shavitt; Y C Janardhan Reddy; Christine Lochner; Dan J Stein; H Blair Simpson; Euripedes C Miguel Journal: Mol Psychiatry Date: 2021-01-07 Impact factor: 15.992