Yasemin Aydoğan1, Mustafa Altay2, Oktay Ünsal3, Veysel Kaplanoğlu4, Yavuz Çağır5, Canan Yıldız6, Esin Beyan7, Selma Uysal Ramadan8. 1. Zonguldak Devrek State Hospital, Zonguldak, Turkey. yaseminunsalay@gmail.com. 2. Department of Endocrinology, Keçiören Training and Research Hospital, Ankara, Turkey. 3. Department of Nefrology, Uludağ University Medical Faculty Hospital, Bursa, Turkey. 4. Department of Radiology, Keçiören Training ad Research Hospital, Ankara, Turkey. 5. Çankırı Çerkeş State Hospital, Çankırı, Turkey. 6. Aydın Didim State Hospital, Aydın, Didim, Turkey. 7. Department of Internal Medicine, Keçiören Training and Research Hospital, Ankara, Turkey. 8. Deparment of Radiology, Keçiören Training and Research Hospital, Ankara, Turkey.
Abstract
OBJECTIVES: Publications suggesting that thyroid nodule might be associated with insulin resistance and metabolic syndrome are quite interesting. There is a need for studies assessing the relationship between nodule presence and cardiovascular risk in individuals with non-functioning nodular goiter. The purpose of the present study is to reveal whether or not insulin resistance, nodule presence, and nodule stiffness affect arterial stiffness, which is a reliable and valid cardiovascular risk indicator, in individuals with euthyroid nodular goiter using the pulse wave analysis (PWA). MATERIALS AND METHODS: 50 patients with euthyroid nodular goiter and 50 healthy volunteers were included in the study. All participants were examined by B-mode thyroid ultrasound, and the participants in the nodular goiter group were also examined by strain elastography (SE). The strain index of nodules was calculated according to the Rago scoring. Also, fasting plasma glucose (FPG) and insulin levels were measured, and HOMA-IR. Arterial stiffness measurements of the participants were performed using a PWA device which employs a cuff-based oscillometric method from the brachial artery. RESULTS: PWV was found to be significantly higher in the euthyroid nodular goiter group (p < 0.001). PWV was found to be positively correlated with FPG and waist circumference. Fasting plasma glucose was found to be higher in the group with nodular goiter (p = 0.03). However, no difference was found between the groups in terms of HOMA-IR and insulin level. HOMA-IR was not correlated with thyroid volume, nodule volume, and nodule count. Also, HOMA-IR was not correlated with strain index value and PWA data. CONCLUSION: We found that PWV was significantly higher in patients with euthyroid nodular goiter. This result suggests that these patients may be at risk for cardiovascular disease.
OBJECTIVES: Publications suggesting that thyroid nodule might be associated with insulin resistance and metabolic syndrome are quite interesting. There is a need for studies assessing the relationship between nodule presence and cardiovascular risk in individuals with non-functioning nodular goiter. The purpose of the present study is to reveal whether or not insulin resistance, nodule presence, and nodule stiffness affect arterial stiffness, which is a reliable and valid cardiovascular risk indicator, in individuals with euthyroid nodular goiter using the pulse wave analysis (PWA). MATERIALS AND METHODS: 50 patients with euthyroid nodular goiter and 50 healthy volunteers were included in the study. All participants were examined by B-mode thyroid ultrasound, and the participants in the nodular goiter group were also examined by strain elastography (SE). The strain index of nodules was calculated according to the Rago scoring. Also, fasting plasma glucose (FPG) and insulin levels were measured, and HOMA-IR. Arterial stiffness measurements of the participants were performed using a PWA device which employs a cuff-based oscillometric method from the brachial artery. RESULTS: PWV was found to be significantly higher in the euthyroid nodular goiter group (p < 0.001). PWV was found to be positively correlated with FPG and waist circumference. Fasting plasma glucose was found to be higher in the group with nodular goiter (p = 0.03). However, no difference was found between the groups in terms of HOMA-IR and insulin level. HOMA-IR was not correlated with thyroid volume, nodule volume, and nodule count. Also, HOMA-IR was not correlated with strain index value and PWA data. CONCLUSION: We found that PWV was significantly higher in patients with euthyroid nodular goiter. This result suggests that these patients may be at risk for cardiovascular disease.
Authors: Chaoyang Li; Earl S Ford; Lisa C McGuire; Ali H Mokdad; Randie R Little; Gerald M Reaven Journal: Diabetes Care Date: 2006-11 Impact factor: 19.112
Authors: Alexander Gotschy; Elisabeth Bauer; Christian Schrodt; Gunthard Lykowsky; Yu-Xiang Ye; Eberhard Rommel; Peter M Jakob; Wolfgang R Bauer; Volker Herold Journal: Circ Cardiovasc Imaging Date: 2013-10-07 Impact factor: 7.792