Literature DB >> 30083393

The drive to taper opioids: mind the evidence, and the ethics.

Stefan G Kertesz1,2, Ajay Manhapra3,4,5.   

Abstract

The high prevalence of pain in patients with spinal cord injury, coupled with a national recalibration of opioid prescribing, presents a challenge. Prescribers may attempt to taper opioids, where observable harms from the prescribed opioid appear to outweigh benefits, a stance endorsed by the 2016 Guideline for Prescribing Opioids for Chronic Pain, issued by the Centers for Disease Control and Prevention. Different considerations apply when clinicians wish to reduce doses in adherent and stable patients, absent their consent. In this perspective piece, we acknowledge the problematic nature of opioids as a treatment. However, forced tapers may destabilize patients and clinical evidence to support forced tapers is lacking. We favor an ethic of informed consent when proposing changes to care involve meaningful risk, and suggest alternative approaches to optimizing safety.

Entities:  

Year:  2018        PMID: 30083393      PMCID: PMC6063968          DOI: 10.1038/s41394-018-0092-5

Source DB:  PubMed          Journal:  Spinal Cord Ser Cases        ISSN: 2058-6124


  25 in total

1.  Hailey.

Authors:  William B Weeks
Journal:  JAMA       Date:  2016-11-15       Impact factor: 56.272

2.  Opioid dose and drug-related mortality in patients with nonmalignant pain.

Authors:  Tara Gomes; Muhammad M Mamdani; Irfan A Dhalla; J Michael Paterson; David N Juurlink
Journal:  Arch Intern Med       Date:  2011-04-11

3.  Turning the tide or riptide? The changing opioid epidemic.

Authors:  Stefan G Kertesz
Journal:  Subst Abus       Date:  2016-11-18       Impact factor: 3.716

4.  Long-term opioid use in non-cancer pain.

Authors:  Winfried Häuser; Fritjof Bock; Peter Engeser; Thomas Tölle; Anne Willweber-Strumpfe; Frank Petzke
Journal:  Dtsch Arztebl Int       Date:  2014-10-24       Impact factor: 5.594

5.  Opioid Analgesic Use and Risk for Invasive Pneumococcal Diseases: A Nested Case-Control Study.

Authors:  Andrew D Wiese; Marie R Griffin; William Schaffner; C Michael Stein; Robert A Greevy; Edward F Mitchel; Carlos G Grijalva
Journal:  Ann Intern Med       Date:  2018-02-13       Impact factor: 25.391

6.  The conundrum of opioid tapering in long-term opioid therapy for chronic pain: A commentary.

Authors:  Ajay Manhapra; Albert J Arias; Jane C Ballantyne
Journal:  Subst Abus       Date:  2017-10-18       Impact factor: 3.716

7.  Effect of Opioid vs Nonopioid Medications on Pain-Related Function in Patients With Chronic Back Pain or Hip or Knee Osteoarthritis Pain: The SPACE Randomized Clinical Trial.

Authors:  Erin E Krebs; Amy Gravely; Sean Nugent; Agnes C Jensen; Beth DeRonne; Elizabeth S Goldsmith; Kurt Kroenke; Matthew J Bair; Siamak Noorbaloochi
Journal:  JAMA       Date:  2018-03-06       Impact factor: 56.272

8.  Low Risk of Producing an Opioid Use Disorder in Primary Care by Prescribing Opioids to Prescreened Patients with Chronic Noncancer Pain.

Authors:  Martin D Cheatle; Rollin M Gallagher; Charles P O'Brien
Journal:  Pain Med       Date:  2018-04-01       Impact factor: 3.750

9.  Opioid use behaviors, mental health and pain--development of a typology of chronic pain patients.

Authors:  Caleb J Banta-Green; Joseph O Merrill; Suzanne R Doyle; Denise M Boudreau; Donald A Calsyn
Journal:  Drug Alcohol Depend       Date:  2009-05-26       Impact factor: 4.492

Review 10.  Patient Outcomes in Dose Reduction or Discontinuation of Long-Term Opioid Therapy: A Systematic Review.

Authors:  Joseph W Frank; Travis I Lovejoy; William C Becker; Benjamin J Morasco; Christopher J Koenig; Lilian Hoffecker; Hannah R Dischinger; Steven K Dobscha; Erin E Krebs
Journal:  Ann Intern Med       Date:  2017-07-11       Impact factor: 25.391

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  2 in total

1.  Opioid moderatism and the imperative of rapprochement in pain medicine.

Authors:  Michael E Schatman; Alexis Vasciannie; Ronald J Kulich
Journal:  J Pain Res       Date:  2019-02-12       Impact factor: 3.133

2.  Association of Dose Tapering With Overdose or Mental Health Crisis Among Patients Prescribed Long-term Opioids.

Authors:  Alicia Agnoli; Guibo Xing; Daniel J Tancredi; Elizabeth Magnan; Anthony Jerant; Joshua J Fenton
Journal:  JAMA       Date:  2021-08-03       Impact factor: 56.272

  2 in total

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