Literature DB >> 30082889

Sex differences in antidepressant efficacy.

Tara A LeGates1, Mark D Kvarta2, Scott M Thompson3,2.   

Abstract

Sex differences have been observed across many psychiatric diseases, especially mood disorders. For major depression, the most prevalent psychiatric disorder, females show a roughly two-fold greater risk as compared to males. Depression is sexually dimorphic with males and females exhibiting differences in clinical presentation, course, and response to antidepressant treatment. In this review, we first discuss sex differences observed in depressed patients, as well as animal models that reveal potential underlying mechanisms. We then discuss antidepressant treatments including their proposed mechanism of action and sex differences observed in treatment response. We include possible mechanisms underlying these sex differences with particular focus on synaptic transmission.

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Year:  2018        PMID： 30082889      PMCID： PMC6235879          DOI： 10.1038/s41386-018-0156-z

Source DB:  PubMed          Journal:  Neuropsychopharmacology        ISSN： 0893-133X            Impact factor:   7.853


  239 in total

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4.  Sex differences in the prevalence and detection of depressive and anxiety disorders in general health care settings: report from the World Health Organization Collaborative Study on Psychological Problems in General Health Care.

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Review 5.  Animal models of anxiety and depression: how are females different?

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Review 6.  Sex differences in the pharmacokinetics and pharmacodynamics of antidepressants: an updated review.

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8.  Sex and depression in the National Comorbidity Survey. I: Lifetime prevalence, chronicity and recurrence.

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Review 9.  Pharmacokinetics and pharmacodynamics of psychotropic drugs: effect of sex.

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  35 in total

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8.  Childhood trauma mediates repetitive transcranial magnetic stimulation efficacy in major depressive disorder.

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Review 10.  The Effects of Biological Sex on Sepsis Treatments in Animal Models: A Systematic Review and a Narrative Elaboration on Sex- and Gender-Dependent Differences in Sepsis.

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