Pau Redon1,2, Alessandro Maloberti3, Rita Facchetti3, Josep Redon2,4, Empar Lurbe1,4, Michele Bombelli3, Giuseppe Mancia3, Guido Grassi3,5. 1. Pediatric Department of Consorcio Hospital General Universitario de Valencia. 2. CIBER Fisiopatología Obesidad y Nutrición, Instituto de Salud Carlos III, Valencia, Spain. 3. Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy. 4. Hypertension Clinic, Hospital Clinico, INCLIVA, University of Valencia, Spain. 5. IRCCS Multimedica, Sesto San Giovanni (Milan), Italy.
Abstract
OBJECTIVE: Hyperuricemia has been associated with high blood pressure (BP) values, diabetes mellitus, metabolic syndrome and chronic kidney disease (CKD). In the present study, we assessed the gender-related relationships between serum uric acid (SUA) and cardionephrometabolic variables in central and east European hypertensive patients. METHODS: A total of 3206 treated hypertensive patients with available SUA levels from the BP-CARE study was analyzed. Correlations among SUA, BP values, BP control, diabetes mellitus, metabolic syndrome and CKD were performed according to gender. RESULTS: Twenty-five percent of the whole population showed hyperuricemia (28% in women and 23% in men). These patients were older and showed a greater burden of cardiovascular risk factors (high BP, BMI, glucose, total cholesterol and triglyceridemia). They also showed a greater prevalence of metabolic syndrome, diabetes mellitus, rate of uncontrolled BP, more than high cardiovascular risk and CKD. Prevalence of metabolic syndrome and uncontrolled BP was similar in normouricemic and hyperuricemic women, the latter displaying a higher prevalence of diabetes mellitus, high cardiovascular risk and CKD. Hyperuricemic men were characterized by a greater prevalence of metabolic syndrome, diabetes mellitus, high cardiovascular risk, rate of uncontrolled BP and CKD but not polytherapy. Logistic regression analysis showed that none of the evaluated variables, except CKD, displayed SUA as significant covariate. CONCLUSION: Our findings provide evidence that a high prevalence of hyperuricemia occurs in hypertensive patients from central and east Europe. The data also show that gender-related differences in the association between SUA and cardionephrometabolic variables exist. This is also the case for the relationships between SUA and CKD.
OBJECTIVE:Hyperuricemia has been associated with high blood pressure (BP) values, diabetes mellitus, metabolic syndrome and chronic kidney disease (CKD). In the present study, we assessed the gender-related relationships between serum uric acid (SUA) and cardionephrometabolic variables in central and east European hypertensivepatients. METHODS: A total of 3206 treated hypertensivepatients with available SUA levels from the BP-CARE study was analyzed. Correlations among SUA, BP values, BP control, diabetes mellitus, metabolic syndrome and CKD were performed according to gender. RESULTS: Twenty-five percent of the whole population showed hyperuricemia (28% in women and 23% in men). These patients were older and showed a greater burden of cardiovascular risk factors (high BP, BMI, glucose, total cholesterol and triglyceridemia). They also showed a greater prevalence of metabolic syndrome, diabetes mellitus, rate of uncontrolled BP, more than high cardiovascular risk and CKD. Prevalence of metabolic syndrome and uncontrolled BP was similar in normouricemic and hyperuricemicwomen, the latter displaying a higher prevalence of diabetes mellitus, high cardiovascular risk and CKD. Hyperuricemicmen were characterized by a greater prevalence of metabolic syndrome, diabetes mellitus, high cardiovascular risk, rate of uncontrolled BP and CKD but not polytherapy. Logistic regression analysis showed that none of the evaluated variables, except CKD, displayed SUA as significant covariate. CONCLUSION: Our findings provide evidence that a high prevalence of hyperuricemia occurs in hypertensivepatients from central and east Europe. The data also show that gender-related differences in the association between SUA and cardionephrometabolic variables exist. This is also the case for the relationships between SUA and CKD.
Authors: Xiqun Chen; Chizoba C Umeh; Robert E Tainsh; Danielle D Feng; Michael Maguire; Fuxing Zuo; Maryam Rahimian; Robert Logan; Xinliumei Wang; Alberto Ascherio; Eric A Macklin; Emmanuel S Buys; Michael A Schwarzschild Journal: EBioMedicine Date: 2018-11-08 Impact factor: 8.143