Fabio Baganate1, Eliza W Beal1, Dmitry Tumin2, Daniel Azoulay3, Khalid Mumtaz4, Sylvester M Black1, Kenneth Washburn1, Timothy M Pawlik5. 1. Department of General Surgery, Division of Transplantation, The Ohio State University Wexner Medical Center, Columbus. 2. Department of Anesthesiology and Pain Medicine, Nationwide Children's Hospital, Columbus, OH. 3. Henri-Mondor Hospital, APHP, University Paris Est Créteil, France. 4. Department of Internal Medicine, Division of Gastroenterology, Hepatology and Nutrition, The Ohio State University Wexner Medical Center, Columbus. 5. Department of General Surgery, Division of Surgical Oncology, The Ohio State University Wexner Medical Center, Columbus. Electronic address: tim.pawlik@osumc.edu.
Abstract
BACKGROUND: The objective of the current study was to define the incidence, as well as time course of mortality within the first year after liver transplantation. METHODS: Data on adult, first-time liver transplant recipients transplanted between February 2002 and June 2016 were obtained from the United Network for Organ Sharing. RESULTS: Among 64,977 who underwent liver transplantation, the incidence of 90-day and 1-year mortality was 5% and 10%, respectively. Although death associated with cardiovascular/cerebrovascular/pulmonary/hemorrhage was the most cause of death within the first 21 days (7-day: 53%), only 20% of liver transplantation patients died from these causes after 180 days. Infections were the most frequent cause of death during 30-180 days after liver transplantation. In contrast, after roughly 200 days from the time of liver transplantation, other causes of death were the most frequent cause of death. Although patients with autoimmune hepatitis, nonalcoholic steatohepatitis, and alcoholic cirrhosis had a similar risk of 1-year mortality, patients undergoing liver transplantation for viral hepatitis and hepatocellular carcinoma had an increased risk of 1-year mortality (viral: OR 1.56; hepatocellular carcinoma: OR 1.57; P < .001). CONCLUSION: Roughly, 1 in 10 patients died within the first year after liver transplantation. The cause of death had a notable, time-specific variation over the first year after liver transplantation.
BACKGROUND: The objective of the current study was to define the incidence, as well as time course of mortality within the first year after liver transplantation. METHODS: Data on adult, first-time liver transplant recipients transplanted between February 2002 and June 2016 were obtained from the United Network for Organ Sharing. RESULTS: Among 64,977 who underwent liver transplantation, the incidence of 90-day and 1-year mortality was 5% and 10%, respectively. Although death associated with cardiovascular/cerebrovascular/pulmonary/hemorrhage was the most cause of death within the first 21 days (7-day: 53%), only 20% of liver transplantation patients died from these causes after 180 days. Infections were the most frequent cause of death during 30-180 days after liver transplantation. In contrast, after roughly 200 days from the time of liver transplantation, other causes of death were the most frequent cause of death. Although patients with autoimmune hepatitis, nonalcoholic steatohepatitis, and alcoholic cirrhosis had a similar risk of 1-year mortality, patients undergoing liver transplantation for viral hepatitis and hepatocellular carcinoma had an increased risk of 1-year mortality (viral: OR 1.56; hepatocellular carcinoma: OR 1.57; P < .001). CONCLUSION: Roughly, 1 in 10 patients died within the first year after liver transplantation. The cause of death had a notable, time-specific variation over the first year after liver transplantation.
Authors: M Trinidad Serrano; Sergio Sabroso; Luis M Esteban; Marina Berenguer; Constantino Fondevila; Sara Lorente; Luis Cortés; Gloria Sanchez-Antolin; Javier Nuño; Gloria De la Rosa; Magdalena Salcedo Journal: Transpl Int Date: 2022-05-09 Impact factor: 3.842
Authors: Khalid Mumtaz; Jannel Lee-Allen; Kyle Porter; Sean Kelly; James Hanje; Lanla F Conteh; Anthony J Michaels; Ashraf El-Hinnawi; Ken Washburn; Sylvester M Black; Marwan S Abougergi Journal: Sci Rep Date: 2020-11-06 Impact factor: 4.379
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