Literature DB >> 3006612

Antioxidant action of antimalarials.

Y Miyachi, A Yoshioka, S Imamura, Y Niwa.   

Abstract

The effects of antimalarials, chloroquine and quinacrine, on the generation of reactive oxygen species were examined both in polymorphonuclear leucocytes and in the xanthine-xanthine oxidase system. Antimalarials showed inhibitory effects on the production of reactive oxygen species probably by affecting cell functions, such as membrane phospholipid methylation. It is suggested that antimalarial agents can work as antioxidants at the site of inflammation protecting against auto-oxidative tissue damage with resultant anti-inflammatory effects.

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Year:  1986        PMID： 3006612      PMCID： PMC1001858          DOI： 10.1136/ard.45.3.244

Source DB:  PubMed          Journal:  Ann Rheum Dis        ISSN： 0003-4967            Impact factor:   19.103


  35 in total

1.  Phagocytic activation of a luminol-dependent chemiluminescence in rabbit alveolar and peritoneal macrophages.

Authors:  R C Allen; L D Loose
Journal:  Biochem Biophys Res Commun       Date:  1976-03-08       Impact factor: 3.575

Review 2.  Antimalarials in the management of discoid and systemic lupus erythematosus.

Authors:  E L Dubois
Journal:  Semin Arthritis Rheum       Date:  1978-08       Impact factor: 5.532

Review 3.  Antimalarial agents. Chloroquine, hydroxychloroquine, and quinacrine.

Authors:  L Tanenbaum; D L Tuffanelli
Journal:  Arch Dermatol       Date:  1980-05

4.  Auto-oxidative damage in Behçet's disease--endothelial cell damage following the elevated oxygen radicals generated by stimulated neutrophils.

Authors:  Y Niwa; S Miyake; T Sakane; M Shingu; M Yokoyama
Journal:  Clin Exp Immunol       Date:  1982-07       Impact factor: 4.330

5.  Increased hydroxyl radical generation by normal polymorphonuclear leukocytes incubated in sera from patients with leukocytoclastic vasculitis.

Authors:  Y Miyachi; K Yanase; S Imamura; Y Niwa
Journal:  Arch Dermatol Res       Date:  1982       Impact factor: 3.017

6.  Effects of thalidomide on the generation of oxygen intermediates by zymosan-stimulated normal polymorphonuclear leukocytes.

Authors:  Y Miyachi; M Ozaki; K Uchida; Y Niwa
Journal:  Arch Dermatol Res       Date:  1982       Impact factor: 3.017

7.  Role of stimulated neutrophils from patients with systemic lupus erythematosus in disturbed immunoreactivity, with special reference to increased oxygen intermediates generated by the neutrophils.

Authors:  Y Niwa; T Sakane; M Shingu; M Yokoyama
Journal:  J Clin Lab Immunol       Date:  1984-05

8.  H2O2 release from human granulocytes during phagocytosis. Relationship to superoxide anion formation and cellular catabolism of H2O2: studies with normal and cytochalasin B-treated cells.

Authors:  R K Root; J A Metcalf
Journal:  J Clin Invest       Date:  1977-12       Impact factor: 14.808

Review 9.  Phospholipid methylation and biological signal transmission.

Authors:  F Hirata; J Axelrod
Journal:  Science       Date:  1980-09-05       Impact factor: 47.728

10.  Effect of cytochalasin B on response of human polymorphonuclear leukocytes to zymosan.

Authors:  J L Skosey; D Chow; E Damgaard; L B Sorensen
Journal:  J Cell Biol       Date:  1973-04       Impact factor: 10.539
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  7 in total

1.  Studies on the mechanism of inhibition of chemotactic tripeptide stimulated human neutrophil polymorphonuclear leucocyte superoxide production by chloroquine and hydroxychloroquine.

Authors:  N P Hurst; J K French; L Gorjatschko; W H Betts
Journal:  Ann Rheum Dis       Date:  1987-10       Impact factor: 19.103

2.  The digestion of bacterial macromolecules by phagocytic cells: the effect of mepacrine and ethanol.

Authors:  P J Roberts; A W Segal
Journal:  Immunology       Date:  1987-12       Impact factor: 7.397

3.  Uptake of chloroquine and hydroxychloroquine by human blood leucocytes in vitro: relation to cellular concentrations during antirheumatic therapy.

Authors:  J K French; N P Hurst; M L O'Donnell; W H Betts
Journal:  Ann Rheum Dis       Date:  1987-01       Impact factor: 19.103

4.  Novel drug delivery of dual acting prodrugs of hydroxychloroquine with aryl acetic acid NSAIDs: Design, kinetics and pharmacological study.

Authors:  Joshi Poorvashree; Dhaneshwar Suneela
Journal:  Drug Deliv Transl Res       Date:  2017-10       Impact factor: 4.617

5.  Effect of antiinflammatory drugs on human interleukin-1-induced cartilage degradation.

Authors:  E C Arner; L R Darnell; M A Pratta; R C Newton; N R Ackerman; W Galbraith
Journal:  Agents Actions       Date:  1987-08

Review 6.  Therapy and pharmacological properties of hydroxychloroquine and chloroquine in treatment of systemic lupus erythematosus, rheumatoid arthritis and related diseases.

Authors:  K D Rainsford; Ann L Parke; Matthew Clifford-Rashotte; W F Kean
Journal:  Inflammopharmacology       Date:  2015-08-06       Impact factor: 5.093

7.  Hydroxychloroquine Mitigates the Production of 8-Isoprostane and Improves Vascular Dysfunction: Implications for Treating Preeclampsia.

Authors:  Rahana Abd Rahman; Padma Murthi; Harmeet Singh; Seshini Gurungsinghe; Bryan Leaw; Joanne C Mockler; Rebecca Lim; Euan M Wallace
Journal:  Int J Mol Sci       Date:  2020-04-03       Impact factor: 5.923
  7 in total

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