Literature DB >> 2825613

Studies on the mechanism of inhibition of chemotactic tripeptide stimulated human neutrophil polymorphonuclear leucocyte superoxide production by chloroquine and hydroxychloroquine.

N P Hurst1, J K French, L Gorjatschko, W H Betts.   

Abstract

The effect of chloroquine and hydroxychloroquine on neutrophil superoxide release stimulated by the chemotactic tripeptide N-formyl-methionyl-leucyl-phenylalanine (FMLP) was examined. Both drugs caused time and dose dependent inhibition of superoxide release but had no effect on equilibrium binding of [3H]FMLP to its receptor. Preliminary experiments suggest that these drugs may exert their inhibitory effect on superoxide release by inhibiting the FMLP stimulated hydrolysis of phosphoinositides.

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Year:  1987        PMID： 2825613      PMCID： PMC1003382          DOI： 10.1136/ard.46.10.750

Source DB:  PubMed          Journal:  Ann Rheum Dis        ISSN： 0003-4967            Impact factor:   19.103


  18 in total

Review 1.  Molecular basis of activation and regulation of the phagocyte respiratory burst.

Authors:  N P Hurst
Journal:  Ann Rheum Dis       Date:  1987-04       Impact factor: 19.103

2.  Breakdown and synthesis of polyphosphoinositides in fMetLeuPhe-stimulated neutrophils.

Authors:  S Cockcroft; M M Barrowman; B D Gomperts
Journal:  FEBS Lett       Date:  1985-02-25       Impact factor: 4.124

3.  Inositol 1,4,5-trisphosphate may be a signal for f-Met-Leu-Phe-induced intracellular Ca mobilisation in human leucocytes (HL-60 cells).

Authors:  G M Burgess; J S McKinney; R F Irvine; M J Berridge; P C Hoyle; J W Putney
Journal:  FEBS Lett       Date:  1984-10-15       Impact factor: 4.124

4.  Receptor-mediated uptake and degradation of 125I-chemotactic peptide by human neutrophils.

Authors:  J Niedel; S Wilkinson; P Cuatrecasas
Journal:  J Biol Chem       Date:  1979-11-10       Impact factor: 5.157

5.  Pharmacologic actions of 4-aminoquinoline compounds.

Authors:  A H Mackenzie
Journal:  Am J Med       Date:  1983-07-18       Impact factor: 4.965

6.  Immunosuppressive potential of antimalarials.

Authors:  G Salmeron; P E Lipsky
Journal:  Am J Med       Date:  1983-07-18       Impact factor: 4.965

7.  Phospholipase A2 and phospholipase C activities of platelets. Differential substrate specificity, Ca2+ requirement, pH dependence, and cellular localization.

Authors:  M M Billah; E G Lapetina; P Cuatrecasas
Journal:  J Biol Chem       Date:  1980-11-10       Impact factor: 5.157

8.  Phospholipid transmethylation in the membrane of human neutrophils and lymphocytes.

Authors:  Y Niwa; T Sakane; S Taniguchi
Journal:  Arch Biochem Biophys       Date:  1984-10       Impact factor: 4.013

9.  Stimulated neutrophils from patients with autosomal recessive chronic granulomatous disease fail to phosphorylate a Mr-44,000 protein.

Authors:  A W Segal; P G Heyworth; S Cockcroft; M M Barrowman
Journal:  Nature       Date:  1985 Aug 8-14       Impact factor: 49.962

10.  The chemosuppression of chemotaxis.

Authors:  P A Ward
Journal:  J Exp Med       Date:  1966-08-01       Impact factor: 14.307
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  3 in total

Review 1.  The role of antimalarial agents in the treatment of SLE and lupus nephritis.

Authors:  Senq-J Lee; Earl Silverman; Joanne M Bargman
Journal:  Nat Rev Nephrol       Date:  2011-10-18       Impact factor: 28.314

2.  Sulphasalazine inhibition of human granulocyte activation by inhibition of second messenger compounds.

Authors:  G Carlin; R Djursäter; G Smedegård
Journal:  Ann Rheum Dis       Date:  1992-11       Impact factor: 19.103

Review 3.  Therapy and pharmacological properties of hydroxychloroquine and chloroquine in treatment of systemic lupus erythematosus, rheumatoid arthritis and related diseases.

Authors:  K D Rainsford; Ann L Parke; Matthew Clifford-Rashotte; W F Kean
Journal:  Inflammopharmacology       Date:  2015-08-06       Impact factor: 5.093
  3 in total

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