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Literature DB >> 300647

Thymoma immunological and ultrastructural characterization.

Abstract

A 69-year-old man with a mediastinal mass was found to have atypical lymphoid cells in peripheral blood and bone marrow. Light and electron microscopic studies showed that the mediastinal mass was a thymoma. B- and T-cell differentiation and PHA responsiveness in the tumor and peripheral blood were consistent with T-cells. After excision of the tumor and a course of radiotherapy the B/T ratio and PHA responsiveness in peripheral blood returned to normal while the atypical lymphocytes disappeared from circulation.

Entities: Disease Species

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Year: 1977 PMID： 300647 DOI： 10.1002/1097-0142(197704)39:4<1455::aid-cncr2820390417>3.0.co;2-#

Source DB: PubMed Journal: Cancer ISSN： 0008-543X Impact factor: 6.860

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Cited

7 in total

1. Impaired expression of MHC class II molecules in response to interferon-gamma (IFN-gamma) on human thymoma neoplastic epithelial cells.

Authors: M Inoue; M Okumura; S Miyoshi; H Shiono; K Fukuhara; Y Kadota; R Shirakura; H Matsuda
Journal: Clin Exp Immunol Date: 1999-07 Impact factor: 4.330

2. Altered T cell development in human thymoma is related to impairment of MHC class II transactivator expression induced by interferon-gamma (IFN-gamma).

Authors: Y Kadota; M Okumura; S Miyoshi; S Kitagawa-Sakakida; M Inoue; H Shiono; Y Maeda; T Kinoshita; R Shirakura; H Matsuda
Journal: Clin Exp Immunol Date: 2000-07 Impact factor: 4.330

3. [A comparative clinical and pathological study on the classification and prognostic features of 57 thymomas. I. Microscopy and ultrastructural pathology (author's transl)].

Authors: H F Otto; H Hüsselmann
Journal: Z Krebsforsch Klin Onkol Cancer Res Clin Oncol Date: 1978-01-26

4. Thymoma and thymic carcinoma. Relation of thymoma epithelial cells to the cortical and medullary differentiation of thymus.

Authors: M Marino; H K Müller-Hermelink
Journal: Virchows Arch A Pathol Anat Histopathol Date: 1985

Thymoma immunological and ultrastructural characterization.

1. Impaired expression of MHC class II molecules in response to interferon-gamma (IFN-gamma) on human thymoma neoplastic epithelial cells.

2. Altered T cell development in human thymoma is related to impairment of MHC class II transactivator expression induced by interferon-gamma (IFN-gamma).

3. [A comparative clinical and pathological study on the classification and prognostic features of 57 thymomas. I. Microscopy and ultrastructural pathology (author's transl)].

4. Thymoma and thymic carcinoma. Relation of thymoma epithelial cells to the cortical and medullary differentiation of thymus.

5. Unusual association of CD8+ T-cell lymphocytosis with invasive thymoma.

Review 6. Bone metastasis of malignant thymomas associated with peripheral T-cell lymphocytosis.

7. Assessment of the prognostic role of neutrophil-to-lymphocyte ratio following complete resection of thymoma.