Literature DB >> 3006457

Endothelium-derived relaxing factor (EDRF).

F V DeFeudis.   

Abstract

Recent studies on endothelium-dependent vasorelaxation have been briefly reviewed and analyzed. The following processes appear to subserve this mechanism: In the endothelial cell: receptor activation, activation of phospholipases, mobilization of intracellular Ca2+, synthesis and release of 'endothelium-derived relaxing factor(s) (EDRF); In the smooth muscle cell: activation of guanyl cyclase and protein kinase, protein phosphorylation/dephosphorylation, relaxation. Alterations of this mechanism could be involved in certain cardiovascular disorders.

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Year:  1985        PMID： 3006457     DOI： 10.1007/bf01966589

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  14 in total

Review 1.  Endothelium-dependent and nitrovasodilator-induced relaxation of vascular smooth muscle: role of cyclic GMP.

Authors:  R M Rapoport; F Murad
Journal:  J Cyclic Nucleotide Protein Phosphor Res       Date:  1983

2.  Species-dependent differences in the nature of endothelium-derived vascular relaxing factor.

Authors:  U Förstermann; G Trogisch; R Busse
Journal:  Eur J Pharmacol       Date:  1984-11-27       Impact factor: 4.432

Review 3.  Free-radical mechanisms in tissue injury.

Authors:  T F Slater
Journal:  Biochem J       Date:  1984-08-15       Impact factor: 3.857

Review 4.  Role of endothelium in responses of vascular smooth muscle.

Authors:  R F Furchgott
Journal:  Circ Res       Date:  1983-11       Impact factor: 17.367

5.  Calcium ionophore A 23187 induces arachidonic acid release from phosphatidylcholine in cultured human endothelial cells.

Authors:  J M Thomas; H Chap; L Douste-Blazy
Journal:  Biochem Biophys Res Commun       Date:  1981-12-15       Impact factor: 3.575

6.  The nature of endothelium-derived vascular relaxant factor.

Authors:  T M Griffith; D H Edwards; M J Lewis; A C Newby; A H Henderson
Journal:  Nature       Date:  1984 Apr 12-18       Impact factor: 49.962

7.  Endothelium-dependent relaxation of rabbit aorta. I. Relaxation stimulated by arachidonic acid.

Authors:  H A Singer; M J Peach
Journal:  J Pharmacol Exp Ther       Date:  1983-09       Impact factor: 4.030

8.  Liver microsomal cytochrome P-450 and the oxidative metabolism of arachidonic acid.

Authors:  J Capdevila; N Chacos; J Werringloer; R A Prough; R W Estabrook
Journal:  Proc Natl Acad Sci U S A       Date:  1981-09       Impact factor: 11.205

Review 9.  Endothelial cells as mediators of vasodilation of arteries.

Authors:  R F Furchgott; P D Cherry; J V Zawadzki; D Jothianandan
Journal:  J Cardiovasc Pharmacol       Date:  1984       Impact factor: 3.105
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