Literature DB >> 30060436

Identification and characterization of EYD1, encoding an erythritol dehydrogenase in Yarrowia lipolytica and its application to bioconvert erythritol into erythrulose.

Frédéric Carly1, Sébastien Steels2, Samuel Telek2, Marie Vandermies2, Jean-Marc Nicaud3, Patrick Fickers4.   

Abstract

In this study, gene YALI0F01650g has been isolated and characterized. Several experimental evidences suggest that the identified gene, renamed EYD1, encodes an erythritol dehydrogenase. An efficient bioreactor process for the bioconversion of erythritol into erythrulose was also developed. Using constitutive expression of EYD1 in a Y. lipolytica mutant containing a disrupted EYK1 gene, which encodes erythrulose kinase, erythrulose could be synthesized from erythritol at a rate of 0.116g/gDCW.h and with a bioconversion yield of 0.64g/g.
Copyright © 2017 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Erythritol; Erythritol dehydrogenase; Erythritol-erythrulose bioconversion; Erythrulose; Yarrowia lipolytic

Mesh：

Substances：

Year:  2017        PMID： 30060436     DOI： 10.1016/j.biortech.2017.09.168

Source DB:  PubMed          Journal:  Bioresour Technol        ISSN： 0960-8524            Impact factor:   9.642


  8 in total

1.  Metabolic engineering of Yarrowia lipolytica for thermoresistance and enhanced erythritol productivity.

Authors:  Nan Wang; Ping Chi; Yawen Zou; Yirong Xu; Shuo Xu; M Bilal; Patrick Fickers; Hairong Cheng
Journal:  Biotechnol Biofuels       Date:  2020-10-20       Impact factor: 6.040

2.  Identification, characterization of two NADPH-dependent erythrose reductases in the yeast Yarrowia lipolytica and improvement of erythritol productivity using metabolic engineering.

Authors:  Huiling Cheng; Siqi Wang; Muhammad Bilal; Xuemei Ge; Can Zhang; Patrick Fickers; Hairong Cheng
Journal:  Microb Cell Fact       Date:  2018-08-29       Impact factor: 5.328

3.  Efficient expression vectors and host strain for the production of recombinant proteins by Yarrowia lipolytica in process conditions.

Authors:  Young-Kyoung Park; Marie Vandermies; Paul Soudier; Samuel Telek; Stéphane Thomas; Jean-Marc Nicaud; Patrick Fickers
Journal:  Microb Cell Fact       Date:  2019-10-10       Impact factor: 5.328

Review 4.  Sugar Alcohols and Organic Acids Synthesis in Yarrowia lipolytica: Where Are We?

Authors:  Patrick Fickers; Hairong Cheng; Carol Sze Ki Lin
Journal:  Microorganisms       Date:  2020-04-15

5.  HOG-Independent Osmoprotection by Erythritol in Yeast Yarrowia lipolytica.

Authors:  Dorota A Rzechonek; Mateusz Szczepańczyk; Guokun Wang; Irina Borodina; Aleksandra M Mirończuk
Journal:  Genes (Basel)       Date:  2020-11-27       Impact factor: 4.096

6.  Yeast metabolic innovations emerged via expanded metabolic network and gene positive selection.

Authors:  Hongzhong Lu; Feiran Li; Le Yuan; Iván Domenzain; Rosemary Yu; Hao Wang; Gang Li; Yu Chen; Boyang Ji; Eduard J Kerkhoven; Jens Nielsen
Journal:  Mol Syst Biol       Date:  2021-10       Impact factor: 11.429

Review 7.  Bioreactor-Scale Strategies for the Production of Recombinant Protein in the Yeast Yarrowia lipolytica.

Authors:  Marie Vandermies; Patrick Fickers
Journal:  Microorganisms       Date:  2019-01-30

8.  Yarrowia lipolytica chassis strains engineered to produce aromatic amino acids via the shikimate pathway.

Authors:  Macarena Larroude; Jean-Marc Nicaud; Tristan Rossignol
Journal:  Microb Biotechnol       Date:  2020-12-30       Impact factor: 5.813
  8 in total

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