Literature DB >> 30060231

Ebolavirus Chimerization for the Development of a Mouse Model for Screening of Bundibugyo-Specific Antibodies.

Philipp A Ilinykh1,2, Jessica Graber2, Natalia A Kuzmina1,2, Kai Huang1,2, Thomas G Ksiazek1,2, James E Crowe3,4,5,6, Alexander Bukreyev1,2,7.   

Abstract

Screening of monoclonal antibodies against ebolaviruses requires small-animal models. Wild-type mice require adaptation of ebolaviruses, whereas immunodeficient mice are still resistant to nonadapted Bundibugyo ebolavirus. Swapping of Ebola virus glycoprotein with that from Bundibugyo virus resulted in a replication-competent chimeric virus, which caused 100% lethal infection in STAT1 knockout mice. Monoclonal antibody BDBV223 isolated from a human survivor of Bundibugyo virus infection protected mice from challenge with the chimeric virus. These data demonstrate the suitability of the approach for in vivo screening of antibodies and suggest the greater contribution of internal Ebola proteins in pathogenesis compared to Bundibugyo virus proteins.

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Year:  2018        PMID： 30060231      PMCID： PMC6249583          DOI： 10.1093/infdis/jiy423

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  24 in total

1.  Mechanism of human antibody-mediated neutralization of Marburg virus.

Authors:  Andrew I Flyak; Philipp A Ilinykh; Charles D Murin; Tania Garron; Xiaoli Shen; Marnie L Fusco; Takao Hashiguchi; Zachary A Bornholdt; James C Slaughter; Gopal Sapparapu; Curtis Klages; Thomas G Ksiazek; Andrew B Ward; Erica Ollmann Saphire; Alexander Bukreyev; James E Crowe
Journal:  Cell       Date:  2015-02-26       Impact factor: 41.582

Review 2.  Mechanisms of type-I- and type-II-interferon-mediated signalling.

Authors:  Leonidas C Platanias
Journal:  Nat Rev Immunol       Date:  2005-05       Impact factor: 53.106

3.  Ferrets Infected with Bundibugyo Virus or Ebola Virus Recapitulate Important Aspects of Human Filovirus Disease.

Authors:  Robert Kozak; Shihua He; Andrea Kroeker; Marc-Antoine de La Vega; Jonathan Audet; Gary Wong; Chantel Urfano; Kym Antonation; Carissa Embury-Hyatt; Gary P Kobinger; Xiangguo Qiu
Journal:  J Virol       Date:  2016-09-29       Impact factor: 5.103

4.  Macaque Monoclonal Antibodies Targeting Novel Conserved Epitopes within Filovirus Glycoprotein.

Authors:  Zhen-Yong Keck; Sven G Enterlein; Katie A Howell; Hong Vu; Sergey Shulenin; Kelly L Warfield; Jeffrey W Froude; Nazli Araghi; Robin Douglas; Julia Biggins; Calli M Lear-Rooney; Ariel S Wirchnianski; Patrick Lau; Yong Wang; Andrew S Herbert; John M Dye; Pamela J Glass; Frederick W Holtsberg; Steven K H Foung; M Javad Aman
Journal:  J Virol       Date:  2015-10-14       Impact factor: 5.103

5.  Neutralizing the Threat: Pan-Ebolavirus Antibodies Close the Loop.

Authors:  Chad E Mire; Thomas W Geisbert
Journal:  Trends Mol Med       Date:  2017-07-08       Impact factor: 11.951

Review 6.  Rodent-Adapted Filoviruses and the Molecular Basis of Pathogenesis.

Authors:  Logan Banadyga; Michael A Dolan; Hideki Ebihara
Journal:  J Mol Biol       Date:  2016-05-14       Impact factor: 5.469

Review 7.  Neglected filoviruses.

Authors:  Robin Burk; Laura Bollinger; Joshua C Johnson; Jiro Wada; Sheli R Radoshitzky; Gustavo Palacios; Sina Bavari; Peter B Jahrling; Jens H Kuhn
Journal:  FEMS Microbiol Rev       Date:  2016-06-05       Impact factor: 16.408

8.  Development and characterization of a mouse model for Marburg hemorrhagic fever.

Authors:  Kelly L Warfield; Steven B Bradfute; Jay Wells; Loreen Lofts; Meagan T Cooper; D Anthony Alves; Daniel K Reed; Sean A VanTongeren; Christine A Mech; Sina Bavari
Journal:  J Virol       Date:  2009-04-15       Impact factor: 5.103

9.  The Ebola virus glycoprotein contributes to but is not sufficient for virulence in vivo.

Authors:  Allison Groseth; Andrea Marzi; Thomas Hoenen; Astrid Herwig; Don Gardner; Stephan Becker; Hideki Ebihara; Heinz Feldmann
Journal:  PLoS Pathog       Date:  2012-08-02       Impact factor: 6.823

10.  The Domestic Ferret (Mustela putorius furo) as a Lethal Infection Model for 3 Species of Ebolavirus.

Authors:  Robert W Cross; Chad E Mire; Viktoriya Borisevich; Joan B Geisbert; Karla A Fenton; Thomas W Geisbert
Journal:  J Infect Dis       Date:  2016-05-24       Impact factor: 5.226
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  2 in total

1.  Non-neutralizing Antibodies from a Marburg Infection Survivor Mediate Protection by Fc-Effector Functions and by Enhancing Efficacy of Other Antibodies.

Authors:  Philipp A Ilinykh; Kai Huang; Rodrigo I Santos; Pavlo Gilchuk; Bronwyn M Gunn; Marcus M Karim; Jenny Liang; Mallorie E Fouch; Edgar Davidson; Diptiben V Parekh; James B Kimble; Colette A Pietzsch; Michelle Meyer; Natalia A Kuzmina; Larry Zeitlin; Erica Ollmann Saphire; Galit Alter; James E Crowe; Alexander Bukreyev
Journal:  Cell Host Microbe       Date:  2020-04-21       Impact factor: 21.023

2.  A Fc engineering approach to define functional humoral correlates of immunity against Ebola virus.

Authors:  Bronwyn M Gunn; Richard Lu; Matthew D Slein; Philipp A Ilinykh; Kai Huang; Caroline Atyeo; Sharon L Schendel; Jiyoung Kim; Caitlin Cain; Vicky Roy; Todd J Suscovich; Ayato Takada; Peter J Halfmann; Yoshihiro Kawaoka; Matthias G Pauthner; Mambu Momoh; Augustine Goba; Lansana Kanneh; Kristian G Andersen; John S Schieffelin; Donald Grant; Robert F Garry; Erica Ollmann Saphire; Alexander Bukreyev; Galit Alter
Journal:  Immunity       Date:  2021-04-13       Impact factor: 31.745
  2 in total

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