Literature DB >> 28697885

Neutralizing the Threat: Pan-Ebolavirus Antibodies Close the Loop.

Chad E Mire1, Thomas W Geisbert2.   

Abstract

The glycoprotein (GP) of ebolaviruses participates in a critical membrane fusion process to establish infection of a cell and therefore, represents an important target of both vaccines and antivirals. The latest reports on pan-ebolavirus monoclonal antibodies in small animal models may offer promising outcomes and insight into how best to target the GP in vaccine and antiviral discovery.
Copyright © 2017 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Bundibugyo; Ebolavirus; Sudan; Zaire; antibody; treatment

Mesh：

Substances：

Year:  2017        PMID： 28697885      PMCID： PMC5718150          DOI： 10.1016/j.molmed.2017.06.008

Source DB:  PubMed          Journal:  Trends Mol Med        ISSN： 1471-4914            Impact factor:   11.951


  10 in total

1.  Immunization-Elicited Broadly Protective Antibody Reveals Ebolavirus Fusion Loop as a Site of Vulnerability.

Authors:  Xuelian Zhao; Katie A Howell; Shihua He; Jennifer M Brannan; Anna Z Wec; Edgar Davidson; Hannah L Turner; Chi-I Chiang; Lin Lei; J Maximilian Fels; Hong Vu; Sergey Shulenin; Ashley N Turonis; Ana I Kuehne; Guodong Liu; Mi Ta; Yimeng Wang; Christopher Sundling; Yongli Xiao; Jennifer S Spence; Benjamin J Doranz; Frederick W Holtsberg; Andrew B Ward; Kartik Chandran; John M Dye; Xiangguo Qiu; Yuxing Li; M Javad Aman
Journal:  Cell       Date:  2017-05-18       Impact factor: 41.582

2.  Antibodies from a Human Survivor Define Sites of Vulnerability for Broad Protection against Ebolaviruses.

Authors:  Anna Z Wec; Andrew S Herbert; Charles D Murin; Elisabeth K Nyakatura; Dafna M Abelson; J Maximilian Fels; Shihua He; Rebekah M James; Marc-Antoine de La Vega; Wenjun Zhu; Russell R Bakken; Eileen Goodwin; Hannah L Turner; Rohit K Jangra; Larry Zeitlin; Xiangguo Qiu; Jonathan R Lai; Laura M Walker; Andrew B Ward; John M Dye; Kartik Chandran; Zachary A Bornholdt
Journal:  Cell       Date:  2017-05-18       Impact factor: 41.582

3.  Structures of protective antibodies reveal sites of vulnerability on Ebola virus.

Authors:  Charles D Murin; Marnie L Fusco; Zachary A Bornholdt; Xiangguo Qiu; Gene G Olinger; Larry Zeitlin; Gary P Kobinger; Andrew B Ward; Erica Ollmann Saphire
Journal:  Proc Natl Acad Sci U S A       Date:  2014-11-17       Impact factor: 11.205

4.  Successful treatment of ebola virus-infected cynomolgus macaques with monoclonal antibodies.

Authors:  Xiangguo Qiu; Jonathan Audet; Gary Wong; Stephane Pillet; Alexander Bello; Teresa Cabral; Jim E Strong; Frank Plummer; Cindy R Corbett; Judie B Alimonti; Gary P Kobinger
Journal:  Sci Transl Med       Date:  2012-06-13       Impact factor: 17.956

5.  Postexposure antibody prophylaxis protects nonhuman primates from filovirus disease.

Authors:  John M Dye; Andrew S Herbert; Ana I Kuehne; James F Barth; Majidat A Muhammad; Samantha E Zak; Ramon A Ortiz; Laura I Prugar; William D Pratt
Journal:  Proc Natl Acad Sci U S A       Date:  2012-03-12       Impact factor: 11.205

6.  Delayed treatment of Ebola virus infection with plant-derived monoclonal antibodies provides protection in rhesus macaques.

Authors:  Gene Garrard Olinger; James Pettitt; Do Kim; Cara Working; Ognian Bohorov; Barry Bratcher; Ernie Hiatt; Steven D Hume; Ashley K Johnson; Josh Morton; Michael Pauly; Kevin J Whaley; Calli M Lear; Julia E Biggins; Corinne Scully; Lisa Hensley; Larry Zeitlin
Journal:  Proc Natl Acad Sci U S A       Date:  2012-10-15       Impact factor: 11.205

Review 7.  Structural basis for differential neutralization of ebolaviruses.

Authors:  Shridhar Bale; Joao M Dias; Marnie L Fusco; Takao Hashiguchi; Anthony C Wong; Tong Liu; Ana I Keuhne; Sheng Li; Virgil L Woods; Kartik Chandran; John M Dye; Erica Ollmann Saphire
Journal:  Viruses       Date:  2012-04-05       Impact factor: 5.048

8.  Neutralizing antibody fails to impact the course of Ebola virus infection in monkeys.

Authors:  Wendelien B Oswald; Thomas W Geisbert; Kelly J Davis; Joan B Geisbert; Nancy J Sullivan; Peter B Jahrling; Paul W H I Parren; Dennis R Burton
Journal:  PLoS Pathog       Date:  2007-01       Impact factor: 6.823

9.  Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp.

Authors:  Xiangguo Qiu; Gary Wong; Jonathan Audet; Alexander Bello; Lisa Fernando; Judie B Alimonti; Hugues Fausther-Bovendo; Haiyan Wei; Jenna Aviles; Ernie Hiatt; Ashley Johnson; Josh Morton; Kelsi Swope; Ognian Bohorov; Natasha Bohorova; Charles Goodman; Do Kim; Michael H Pauly; Jesus Velasco; James Pettitt; Gene G Olinger; Kevin Whaley; Bianli Xu; James E Strong; Larry Zeitlin; Gary P Kobinger
Journal:  Nature       Date:  2014-08-29       Impact factor: 49.962

10.  Passive Immunotherapy: Assessment of Convalescent Serum Against Ebola Virus Makona Infection in Nonhuman Primates.

Authors:  Chad E Mire; Joan B Geisbert; Krystle N Agans; Emily P Thi; Amy C H Lee; Karla A Fenton; Thomas W Geisbert
Journal:  J Infect Dis       Date:  2016-08-28       Impact factor: 5.226
  10 in total
  4 in total

1.  Ebolavirus Chimerization for the Development of a Mouse Model for Screening of Bundibugyo-Specific Antibodies.

Authors:  Philipp A Ilinykh; Jessica Graber; Natalia A Kuzmina; Kai Huang; Thomas G Ksiazek; James E Crowe; Alexander Bukreyev
Journal:  J Infect Dis       Date:  2018-11-22       Impact factor: 5.226

2.  Efficacy of Human Monoclonal Antibody Monotherapy Against Bundibugyo Virus Infection in Nonhuman Primates.

Authors:  Pavlo Gilchuk; Chad E Mire; Joan B Geisbert; Krystle N Agans; Daniel J Deer; Robert W Cross; James C Slaughter; Andrew I Flyak; Jeremy Mani; Michael H Pauly; Jesus Velasco; Kevin J Whaley; Larry Zeitlin; Thomas W Geisbert; James E Crowe
Journal:  J Infect Dis       Date:  2018-11-22       Impact factor: 5.226

3.  Single-component multilayered self-assembling nanoparticles presenting rationally designed glycoprotein trimers as Ebola virus vaccines.

Authors:  Linling He; Anshul Chaudhary; Xiaohe Lin; Cindy Sou; Tanwee Alkutkar; Sonu Kumar; Timothy Ngo; Ezra Kosviner; Gabriel Ozorowski; Robyn L Stanfield; Andrew B Ward; Ian A Wilson; Jiang Zhu
Journal:  Nat Commun       Date:  2021-05-11       Impact factor: 14.919

4.  Pan-Filovirus Serum Neutralizing Antibodies in a Subset of Congolese Ebolavirus Infection Survivors.

Authors:  Matthew S Bramble; Nicole Hoff; Pavlo Gilchuk; Patrick Mukadi; Kai Lu; Reena H Doshi; Imke Steffen; Bradly P Nicholson; Allen Lipson; Neerja Vashist; Cyrus Sinai; D'andre Spencer; Garrard Olinger; Emile Okitolonda Wemakoy; Benoit Kebela Illunga; James Pettitt; James Logue; Jonathan Marchand; Justin Varughese; Richard S Bennett; Peter Jahrling; Guy Cavet; Tito Serafini; Erica Ollmann Saphire; Eric Vilain; Jean Jacques Muyembe-Tamfum; Lisa E Hensely; Graham Simmons; James E Crowe; Anne W Rimoin
Journal:  J Infect Dis       Date:  2018-11-05       Impact factor: 5.226
  4 in total

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