Literature DB >> 30059621

Optical Analysis of Reaction Yield and Enantiomeric Excess: A New Paradigm Ready for Prime Time.

Brenden T Herrera1, Samantha L Pilicer2, Eric V Anslyn1, Leo A Joyce3, Christian Wolf2.   

Abstract

This Perspective highlights the advances of optical methods for asymmetric reaction discovery. Optical analysis allows for the determination of absolute configuration, enantiomeric excess and reaction yield that is amenable to high-throughput experimentation. Thus, the synthetic organic community is encouraged to incorporate the methods discussed to expedite the development of high-yielding, enantioselective transformations.

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Year:  2018        PMID: 30059621     DOI: 10.1021/jacs.8b06607

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN: 0002-7863            Impact factor:   15.419


  9 in total

1.  Next-Generation TLC: A Quantitative Platform for Parallel Spotting and Imaging.

Authors:  Alexander A Boulgakov; Sarah R Moor; Hyun Hwa Jo; Pedro Metola; Leo A Joyce; Edward M Marcotte; Christopher J Welch; Eric V Anslyn
Journal:  J Org Chem       Date:  2020-07-06       Impact factor: 4.354

2.  Data-Driven Prediction of Circular Dichroism-Based Calibration Curves for the Rapid Screening of Chiral Primary Amine Enantiomeric Excess Values.

Authors:  James R Howard; Arya Bhakare; Zara Akhtar; Christian Wolf; Eric V Anslyn
Journal:  J Am Chem Soc       Date:  2022-09-06       Impact factor: 16.383

3.  Screening for generality in asymmetric catalysis.

Authors:  Corin C Wagen; Spencer E McMinn; Eugene E Kwan; Eric N Jacobsen
Journal:  Nature       Date:  2022-09-01       Impact factor: 69.504

4.  High-throughput screening of α-chiral-primary amines to determine yield and enantiomeric excess.

Authors:  Sarah R Moor; James R Howard; Brenden T Herrera; Eric V Anslyn
Journal:  Tetrahedron       Date:  2021-07-05       Impact factor: 2.388

5.  A Colorimetric Method for Quantifying Cis and Trans Alkenes Using an Indicator Displacement Assay.

Authors:  Stephanie A Valenzuela; Hannah S N Crory; Chao-Yi Yao; James R Howard; Gabriel Saucedo; A Prasanna de Silva; Eric V Anslyn
Journal:  Angew Chem Int Ed Engl       Date:  2021-05-13       Impact factor: 16.823

6.  A rapid and sensitive method for chiroptical sensing of α-amino acids via click-like labeling with o-phthalaldehyde and p-toluenethiol.

Authors:  Bo Li; Jie Zhang; Li Li; Gong Chen
Journal:  Chem Sci       Date:  2020-12-22       Impact factor: 9.825

7.  Rapid organocatalytic chirality analysis of amines, amino acids, alcohols, amino alcohols and diols with achiral iso(thio)cyanate probes.

Authors:  Eryn Nelson; Jeffrey S S K Formen; C Wolf
Journal:  Chem Sci       Date:  2021-05-25       Impact factor: 9.825

8.  Helical springs as a color indicator for determining chirality and enantiomeric excess.

Authors:  Katsuhiro Maeda; Daisuke Hirose; Mai Nozaki; Yoichi Shimizu; Taro Mori; Kentaro Yamanaka; Koji Ogino; Tatsuya Nishimura; Tsuyoshi Taniguchi; Munetsugu Moro; Eiji Yashima
Journal:  Sci Adv       Date:  2021-06-30       Impact factor: 14.136

9.  Point-to-Axial Chirality Transmission: A Highly Sensitive Triaryl Chirality Probe for Stereochemical Assignments of Amines.

Authors:  Tomasz Mądry; Agnieszka Czapik; Marcin Kwit
Journal:  J Org Chem       Date:  2020-08-11       Impact factor: 4.354

  9 in total

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