BACKGROUND: Larger grey matter volume of the inferior frontal gyrus (IFG) is among the most replicated biomarkers of genetic risk for bipolar disorders (BD). However, the IFG is a heterogeneous prefrontal region, and volumetric findings can be attributable to changes in cortical thickness (CT), surface area (SA) or gyrification. Here, we investigated the morphometry of IFG in participants at genetic risk for BD. METHODS: We quantified the IFG cortical grey matter volume in 29 affected, 32 unaffected relatives of BD probands, and 42 controls. We then examined SA, CT, and cortical folding in subregions of the IFG. RESULTS: We found volumetric group differences in the right IFG, with the largest volumes in unaffected high-risk and smallest in control participants (F2,192 = 3.07, p = 0.01). The volume alterations were localized to the pars triangularis of the IFG (F2,97 = 4.05, p = 0.02), with no differences in pars opercularis or pars orbitalis. Pars triangularis volume was highly correlated with its SA [Pearson r(101) = 0.88, p < 0.001], which significantly differed between the groups (F2,97 = 4.45, p = 0.01). As with volume, the mean SA of the pars triangularis was greater in unaffected (corrected p = 0.02) and affected relatives (corrected p = 0.05) compared with controls. We did not find group differences in pars triangularis CT or gyrification. CONCLUSIONS: These findings strengthen prior knowledge about the volumetric findings in this region and provide a new insight into the localization and topology of IFG alterations. The unique nature of rIFG morphology in BD, with larger volume and SA early in the course of illness, could have practical implications for detection of participants at risk for BD.
BACKGROUND: Larger grey matter volume of the inferior frontal gyrus (IFG) is among the most replicated biomarkers of genetic risk for bipolar disorders (BD). However, the IFG is a heterogeneous prefrontal region, and volumetric findings can be attributable to changes in cortical thickness (CT), surface area (SA) or gyrification. Here, we investigated the morphometry of IFG in participants at genetic risk for BD. METHODS: We quantified the IFG cortical grey matter volume in 29 affected, 32 unaffected relatives of BD probands, and 42 controls. We then examined SA, CT, and cortical folding in subregions of the IFG. RESULTS: We found volumetric group differences in the right IFG, with the largest volumes in unaffected high-risk and smallest in control participants (F2,192 = 3.07, p = 0.01). The volume alterations were localized to the pars triangularis of the IFG (F2,97 = 4.05, p = 0.02), with no differences in pars opercularis or pars orbitalis. Pars triangularis volume was highly correlated with its SA [Pearson r(101) = 0.88, p &lt; 0.001], which significantly differed between the groups (F2,97 = 4.45, p = 0.01). As with volume, the mean SA of the pars triangularis was greater in unaffected (corrected p = 0.02) and affected relatives (corrected p = 0.05) compared with controls. We did not find group differences in pars triangularis CT or gyrification. CONCLUSIONS: These findings strengthen prior knowledge about the volumetric findings in this region and provide a new insight into the localization and topology of IFG alterations. The unique nature of rIFG morphology in BD, with larger volume and SA early in the course of illness, could have practical implications for detection of participants at risk for BD.
Authors: Sean R McWhinney; Christoph Abé; Martin Alda; Francesco Benedetti; Erlend Bøen; Caterina Del Mar Bonnin; Tiana Borgers; Katharina Brosch; Erick J Canales-Rodríguez; Dara M Cannon; Udo Dannlowski; Ana M Diaz-Zuluaga; Lorielle Dietze; Torbjørn Elvsåshagen; Lisa T Eyler; Janice M Fullerton; Jose M Goikolea; Janik Goltermann; Dominik Grotegerd; Bartholomeus C M Haarman; Tim Hahn; Fleur M Howells; Martin Ingvar; Tilo T J Kircher; Axel Krug; Rayus T Kuplicki; Mikael Landén; Hannah Lemke; Benny Liberg; Carlos Lopez-Jaramillo; Ulrik F Malt; Fiona M Martyn; Elena Mazza; Colm McDonald; Genevieve McPhilemy; Sandra Meier; Susanne Meinert; Tina Meller; Elisa M T Melloni; Philip B Mitchell; Leila Nabulsi; Igor Nenadic; Nils Opel; Roel A Ophoff; Bronwyn J Overs; Julia-Katharina Pfarr; Julian A Pineda-Zapata; Edith Pomarol-Clotet; Joaquim Raduà; Jonathan Repple; Maike Richter; Kai G Ringwald; Gloria Roberts; Alex Ross; Raymond Salvador; Jonathan Savitz; Simon Schmitt; Peter R Schofield; Kang Sim; Dan J Stein; Frederike Stein; Henk S Temmingh; Katharina Thiel; Sophia I Thomopoulos; Neeltje E M van Haren; Holly Van Gestel; Cristian Vargas; Eduard Vieta; Annabel Vreeker; Lena Waltemate; Lakshmi N Yatham; Christopher R K Ching; Ole A Andreassen; Paul M Thompson; Tomas Hajek Journal: Bipolar Disord Date: 2021-12-16 Impact factor: 5.345
Authors: Sonja M C de Zwarte; Rachel M Brouwer; Ingrid Agartz; Martin Alda; André Aleman; Kathryn I Alpert; Carrie E Bearden; Alessandro Bertolino; Catherine Bois; Aurora Bonvino; Elvira Bramon; Elizabeth E L Buimer; Wiepke Cahn; Dara M Cannon; Tyrone D Cannon; Xavier Caseras; Josefina Castro-Fornieles; Qiang Chen; Yoonho Chung; Elena De la Serna; Annabella Di Giorgio; Gaelle E Doucet; Mehmet Cagdas Eker; Susanne Erk; Scott C Fears; Sonya F Foley; Sophia Frangou; Andrew Frankland; Janice M Fullerton; David C Glahn; Vina M Goghari; Aaron L Goldman; Ali Saffet Gonul; Oliver Gruber; Lieuwe de Haan; Tomas Hajek; Emma L Hawkins; Andreas Heinz; Manon H J Hillegers; Hilleke E Hulshoff Pol; Christina M Hultman; Martin Ingvar; Viktoria Johansson; Erik G Jönsson; Fergus Kane; Matthew J Kempton; Marinka M G Koenis; Miloslav Kopecek; Lydia Krabbendam; Bernd Krämer; Stephen M Lawrie; Rhoshel K Lenroot; Machteld Marcelis; Jan-Bernard C Marsman; Venkata S Mattay; Colm McDonald; Andreas Meyer-Lindenberg; Stijn Michielse; Philip B Mitchell; Dolores Moreno; Robin M Murray; Benson Mwangi; Pablo Najt; Emma Neilson; Jason Newport; Jim van Os; Bronwyn Overs; Aysegul Ozerdem; Marco M Picchioni; Anja Richter; Gloria Roberts; Aybala Saricicek Aydogan; Peter R Schofield; Fatma Simsek; Jair C Soares; Gisela Sugranyes; Timothea Toulopoulou; Giulia Tronchin; Henrik Walter; Lei Wang; Daniel R Weinberger; Heather C Whalley; Nefize Yalin; Ole A Andreassen; Christopher R K Ching; Theo G M van Erp; Jessica A Turner; Neda Jahanshad; Paul M Thompson; René S Kahn; Neeltje E M van Haren Journal: Biol Psychiatry Date: 2019-06-13 Impact factor: 13.382
Authors: Pavol Mikolas; Kyra Bröckel; Christoph Vogelbacher; Dirk K Müller; Michael Marxen; Christina Berndt; Cathrin Sauer; Stine Jung; Juliane Hilde Fröhner; Andreas J Fallgatter; Thomas Ethofer; Anne Rau; Tilo Kircher; Irina Falkenberg; Martin Lambert; Vivien Kraft; Karolina Leopold; Andreas Bechdolf; Andreas Reif; Silke Matura; Thomas Stamm; Felix Bermpohl; Jana Fiebig; Georg Juckel; Vera Flasbeck; Christoph U Correll; Philipp Ritter; Michael Bauer; Andreas Jansen; Andrea Pfennig Journal: Transl Psychiatry Date: 2021-09-20 Impact factor: 6.222