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Literature DB >> 3005619

Monoclonal antibodies specific for v-abl- and c-abl-encoded molecules.

L Schiff-Maker, M C Burns, J B Konopka, S Clark, O N Witte, N Rosenberg.

Abstract

Monoclonal antibodies specific for regions of the transforming protein of Abelson murine leukemia virus were prepared. Antibodies directed against the kinase domain inhibited the autophosphorylation of v-abl proteins, and all of the antibodies reacted with the products of the murine and human c-abl loci.

Entities: Gene Species

Mesh：

Substances：

Year: 1986 PMID： 3005619 PMCID： PMC252857

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

26 in total

1. A new mouse myeloma cell line that has lost immunoglobulin expression but permits the construction of antibody-secreting hybrid cell lines.

Authors: J F Kearney; A Radbruch; B Liesegang; K Rajewsky
Journal: J Immunol Date: 1979-10 Impact factor: 5.422

2. Continuous cultures of fused cells secreting antibody of predefined specificity.

Authors: G Köhler; C Milstein
Journal: Nature Date: 1975-08-07 Impact factor: 49.962

3. A normal cell protein cross-reactive to the major Abelson murine leukaemia virus gene product.

Authors: O N Witte; N E Rosenberg; D Baltimore
Journal: Nature Date: 1979-10-04 Impact factor: 49.962

4. Cells nonproductively transformed by Abelson murine leukemia virus express a high molecular weight polyprotein containing structural and nonstructural components.

Authors: F H Reynolds; T L Sacks; D N Deobagkar; J R Stephenson
Journal: Proc Natl Acad Sci U S A Date: 1978-08 Impact factor: 11.205

5. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

Authors: H Towbin; T Staehelin; J Gordon
Journal: Proc Natl Acad Sci U S A Date: 1979-09 Impact factor: 11.205

6. Preparation of syngeneic tumor regressor serum reactive with the unique determinants of the Abelson murine leukemia virus-encoded P120 protein at the cell surface.

Authors: O N Witte; N Rosenberg; D Baltimore
Journal: J Virol Date: 1979-09 Impact factor: 5.103

7. Abelson murine leukemia virus mutants with alterations in the virus-specific P120 molecule.

Authors: N Rosenberg; O N Witte
Journal: J Virol Date: 1980-01 Impact factor: 5.103

8. A transformation-defective mutant of Abelson murine leukemia virus lacks protein kinase activity.

Authors: O N Witte; S Goff; N Rosenberg; D Baltimore
Journal: Proc Natl Acad Sci U S A Date: 1980-08 Impact factor: 11.205

9. Abelson murine leukaemia virus protein is phosphorylated in vitro to form phosphotyrosine.

Authors: O N Witte; A Dasgupta; D Baltimore
Journal: Nature Date: 1980-02-28 Impact factor: 49.962

10. Detection of c-abl tyrosine kinase activity in vitro permits direct comparison of normal and altered abl gene products.

Authors: J B Konopka; O N Witte
Journal: Mol Cell Biol Date: 1985-11 Impact factor: 4.272

22 in total

1. Point mutations in the abl SH2 domain coordinately impair phosphotyrosine binding in vitro and transforming activity in vivo.

Authors: B J Mayer; P K Jackson; R A Van Etten; D Baltimore
Journal: Mol Cell Biol Date: 1992-02 Impact factor: 4.272

2. Gag influences transformation by Abelson murine leukemia virus and suppresses nuclear localization of the v-Abl protein.

Authors: Chae-Ryun Yi; Naomi Rosenberg
Journal: J Virol Date: 2007-06-27 Impact factor: 5.103

3. Charting the molecular network of the drug target Bcr-Abl.

Authors: Marc Brehme; Oliver Hantschel; Jacques Colinge; Ines Kaupe; Melanie Planyavsky; Thomas Köcher; Karl Mechtler; Keiryn L Bennett; Giulio Superti-Furga
Journal: Proc Natl Acad Sci U S A Date: 2009-04-20 Impact factor: 11.205

4. bcr/abl and src but not myc and ras replace v-abl in lymphoid transformation.

Authors: A Engelman; N Rosenberg
Journal: Mol Cell Biol Date: 1990-08 Impact factor: 4.272

5. The murine AIDS virus Gag precursor protein binds to the SH3 domain of c-Abl.

Authors: P Dupraz; N Rebai; S J Klein; N Beaulieu; P Jolicoeur
Journal: J Virol Date: 1997-04 Impact factor: 5.103

6. BCR first exon sequences specifically activate the BCR/ABL tyrosine kinase oncogene of Philadelphia chromosome-positive human leukemias.

Authors: A J Muller; J C Young; A M Pendergast; M Pondel; N R Landau; D R Littman; O N Witte
Journal: Mol Cell Biol Date: 1991-04 Impact factor: 4.272

7. En bloc substitution of the Src homology region 2 domain activates the transforming potential of the c-Abl protein tyrosine kinase.

Authors: A J Muller; A M Pendergast; K Parmar; M H Havlik; N Rosenberg; O N Witte
Journal: Proc Natl Acad Sci U S A Date: 1993-04-15 Impact factor: 11.205

8. Oncogenic activation of c-ABL by mutation within its last exon.

Authors: A Goga; J McLaughlin; A M Pendergast; K Parmar; A Muller; N Rosenberg; O N Witte
Journal: Mol Cell Biol Date: 1993-08 Impact factor: 4.272

9. Temperature-sensitive transformation by an Abelson virus mutant encoding an altered SH2 domain.

Authors: C A Mainville; K Parmar; I Unnikrishnan; L Gong; G D Raffel; N Rosenberg
Journal: J Virol Date: 2001-02 Impact factor: 5.103

10. Mutations affecting the MA portion of the v-Abl protein reveal a conserved role of Gag in Abelson murine leukemia virus (MLV) and Moloney MLV.

Authors: Chae-ryun Yi; Naomi Rosenberg
Journal: J Virol Date: 2008-03-26 Impact factor: 5.103