Gaspar Tuero1, Jesús González2, Laura Sahuquillo3, Anna Freixa4, Isabel Gomila5, Miguel Ángel Elorza6, Bernardino Barceló7. 1. Department of Intensive Care Medicine, Hospital Can Misses, Corona, s/n, 07800 Ibiza, Spain. Electronic address: gtuero@asef.es. 2. Department of Intensive Care Medicine, Hospital Can Misses, Corona, s/n, 07800 Ibiza, Spain. Electronic address: jgonzalez@asef.es. 3. Clinical Analysis Department, Hospital Can Misses, Corona, s/n, 07800 Ibiza, Spain. Electronic address: laurasf@asef.es. 4. Reference Laboratory, Pablo Iglesias, 57, 08908 L'Hospitalet de Llobregat, Barcelona, Spain. Electronic address: boliver@referencelaboratory.es. 5. Clinical Analysis Department, Hospital Universitari Son Llàtzer, Research Institute of Health Sciences (IdISBa), Ctra. de Manacor, 07198 Palma de Mallorca, Spain. Electronic address: isabel.gomila@hsll.es. 6. Clinical Toxicology Unit, Clinical Analysis Department, Hospital Universitari Son Espases, Ctra. de Valldemossa, 79, 07120 Palma de Mallorca, Spain. Electronic address: miguelangel.elorza@ssib.es. 7. Clinical Toxicology Unit, Clinical Analysis Department, Hospital Universitari Son Espases, Research Institute of Health Sciences (IdISBa), Ctra. de Valldemossa, 79, 07120 Palma de Mallorca, Spain. Electronic address: bernardino.barcelo@ssib.es.
Abstract
OBJECTIVE: To evaluate the clinical utility of glycolic acid (GA) determination in the diagnosis and prognosis of ethylene glycol (EG) intoxications. METHOD: Systematic review of serum and/or urine GA concentrations available in the literature in cases of EG poisoning. Present a clinical case in which the determination of the GA was decisive. RESULTS: In total, 137 patients were included. Serum GA concentrations (but not EG) of patients who survive are different from those who die. The optimal cut-off of serum GA to predict mortality was 990.5mg/L (sensitivity 85.2%, specificity 54.3%) with an Odds Ratio of 6.838 (2.868-16.302). In our clinical case, serum EG was negative; however, urine GA was positive (1230.7mg/L). CONCLUSIONS: In all suspected cases of EG poisoning, it is advisable to carry out the simultaneous analysis of EG and GA.
OBJECTIVE: To evaluate the clinical utility of glycolic acid (GA) determination in the diagnosis and prognosis of ethylene glycol (EG) intoxications. METHOD: Systematic review of serum and/or urine GA concentrations available in the literature in cases of EGpoisoning. Present a clinical case in which the determination of the GA was decisive. RESULTS: In total, 137 patients were included. Serum GA concentrations (but not EG) of patients who survive are different from those who die. The optimal cut-off of serum GA to predict mortality was 990.5mg/L (sensitivity 85.2%, specificity 54.3%) with an Odds Ratio of 6.838 (2.868-16.302). In our clinical case, serum EG was negative; however, urine GA was positive (1230.7mg/L). CONCLUSIONS: In all suspected cases of EGpoisoning, it is advisable to carry out the simultaneous analysis of EG and GA.
Authors: Hye Jin Yoo; Keum Ji Jung; Minkyung Kim; Minjoo Kim; Minsik Kang; Sun Ha Jee; Yoonjeong Choi; Jong Ho Lee Journal: Front Physiol Date: 2019-11-19 Impact factor: 4.566