Madalena Sassetti1, Líbia Zé-Zé2,3, João Franco1, José da Cunha1, António Gomes1, Ana Tomé4, Maria-João Alves2. 1. Department of Paediatrics, Hospital Garcia de Orta, Av. Torrado da Silva, Almada, Portugal. 2. National Institute of Health Dr. Ricardo Jorge, Centre for Vectors and Infectious Diseases Research, Av. da Liberdade 5, Águas de Moura, Portugal. 3. Biosystems and Integrative Sciences Institute (BioISI), Edificio TecLabs, Campus da FCUL, Campo Grande, Lisboa, Portugal. 4. Department of Obstetrics and Gynecology, Hospital Garcia de Orta, Av. Torrado da Silva, Almada, Portugal.
Abstract
Background: Zika virus has been responsible for recent outbreaks in the western hemisphere with known neurological complications such as microcephaly. This complication has not been previously documented in continental Africa. Methods: Neurological evaluation of the newborn was performed after birth, at one and two months of age. The mother and the newborn sera samples were tested by immunofluorescent assay (IFA; immunoglobulin G [IgG] and IgM) for Zika virus and the presence of Zika virus ribonucleic acid (RNA) was checked by qualitative real-time reverse transcription polymerase chain reaction (RT-PCR) in placenta, blood and urine samples. Results: We report on a newborn, born in Portugal, with microcephaly with confirmed congenital Zika virus infection (Asian lineage) imported from Angola with typical clinical and imaging findings. Conclusions: To our knowledge this is the first report that shows the circulation of the Asian lineage in Angola and the first report of a congenital Zika syndrome in continental Africa.
Background: Zika virus has been responsible for recent outbreaks in the western hemisphere with known neurological complications such as microcephaly. This complication has not been previously documented in continental Africa. Methods: Neurological evaluation of the newborn was performed after birth, at one and two months of age. The mother and the newborn sera samples were tested by immunofluorescent assay (IFA; immunoglobulin G [IgG] and IgM) for Zika virus and the presence of Zika virusribonucleic acid (RNA) was checked by qualitative real-time reverse transcription polymerase chain reaction (RT-PCR) in placenta, blood and urine samples. Results: We report on a newborn, born in Portugal, with microcephaly with confirmed congenital Zika virus infection (Asian lineage) imported from Angola with typical clinical and imaging findings. Conclusions: To our knowledge this is the first report that shows the circulation of the Asian lineage in Angola and the first report of a congenital Zika syndrome in continental Africa.
Authors: Angelica Cifuentes Kottkamp; Elfie De Jesus; Rebecca Grande; Julia A Brown; Adam R Jacobs; Jean K Lim; Kenneth A Stapleford Journal: J Virol Date: 2019-05-15 Impact factor: 5.103
Authors: Sarah C Hill; Jocelyne Vasconcelos; Zoraima Neto; Domingos Jandondo; Líbia Zé-Zé; Renato Santana Aguiar; Joilson Xavier; Julien Thézé; Marinela Mirandela; Ana Luísa Micolo Cândido; Filipa Vaz; Cruz Dos Santos Sebastião; Chieh-Hsi Wu; Moritz U G Kraemer; Adriana Melo; Bruno L F Schamber-Reis; Girlene S de Azevedo; Amilcar Tanuri; Luiza M Higa; Carina Clemente; Sara Pereira da Silva; Darlan da Silva Candido; Ingra M Claro; Domingos Quibuco; Cristóvão Domingos; Bárbara Pocongo; Alexander G Watts; Kamran Khan; Luiz Carlos Junior Alcantara; Ester C Sabino; Eve Lackritz; Oliver G Pybus; Maria-João Alves; Joana Afonso; Nuno R Faria Journal: Lancet Infect Dis Date: 2019-10 Impact factor: 25.071
Authors: Ludmila Lobkowicz; Grace M Power; Wayner Vieira De Souza; Ulisses Ramos Montarroyos; Celina Maria Turchi Martelli; Thalia Velho Barreto de Araùjo; Luciana Caroline Albuquerque Bezerra; Rafael Dhalia; Ernesto T A Marques; Demócrito de Barros Miranda-Filho; Elizabeth B Brickley; Ricardo Arraes de Alencar Ximenes Journal: BMJ Glob Health Date: 2021-12