Mihai Merzianu1, Adrienne Groman2, Alan Hutson2, Claudiu Cotta3, Russell K Brynes4, Attilio Orazi5, Vishnu Reddy6, Julie Teruya-Feldstein7, Ramila Amre8, Manjula Balasubramanian9, Guilherme Brandao10, Sindhu Cherian11, Elizabeth Courville12, David Czuchlewski13, Guang Fan14, David Grier15, Daniela Hoehn16, Kedar V Inamdar17, Ridas Juskevicius18, Prabhjot Kaur19, John Lazarchick20, Michael R Lewis21, Rodney R Miles22, Jerome B Myers23, Michel R Nasr24, Hina N Qureishi25, Horatiu Olteanu26, Valentin G Robu27, Gratian Salaru28, Neerja Vajpayee29, Jeffrey Vos30, Ling Zhang31, Shanxiang Zhang32, Le Aye4, Elisa Brega10, James E Coad30, John Grantham30, Sinisa Ivelja33, Robert McKenna12, Kieran Sultan24, Gregory Wilding2, Robert Hutchison29, LoAnn Peterson34, Richard T Cheney35. 1. Pathology and Laboratory Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY. 2. Biostatistics & Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, NY. 3. Laboratory Medicine, Cleveland Clinic, Cleveland, OH. 4. Pathology, Keck School of Medicine of USC, Los Angeles. 5. Pathology, Weill Cornell Medical College, New York, NY. 6. Pathology, University of Alabama, Birmingham. 7. Pathology, Memorial Sloan Kettering Cancer Center, New York, NY. 8. Pathology, McGill University Health Centre , Royal Victoria Hospital, Montreal, Canada. 9. Clinical Pathology, Albert Einstein Medical Center, Philadelphia, PA. 10. Pathology, McGill University Jewish General Hospital, Montreal, Canada. 11. Laboratory Medicine, University of Washington, Seattle. 12. Laboratory Medicine and Pathology, University of Minnesota, Minneapolis. 13. Pathology, University of New Mexico, Albuquerque. 14. Pathology, Oregon Health and Science University, Portland. 15. Pathology, Wake Forest Baptist Medical Center, Winston-Salem, NC. 16. Pathology and Cell Biology, Columbia University Medical Center, New York, NY. 17. Pathology, Henry Ford Health System, Detroit, MI. 18. Pathology, East Carolina University Brody School of Medicine, Greenville, NC. 19. Pathology, Dartmouth-Hitchcock Medical Center, Lebanon, NH. 20. Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston. 21. Pathology and Laboratory Medicine, University of Vermont, Burlington. 22. Pathology, University of Utah, Salt Lake City. 23. Pathology, Penrose Saint Francis Health Services, Colorado Springs, CO. 24. Pathology, University of Manitoba, Winnipeg, Canada. 25. Pathology and Microbiology, University of Nebraska Medical Center, Omaha. 26. Pathology, Medical College of Wisconsin, Milwaukee. 27. Pathology, Fox Chase Cancer Center, Philadelphia, PA. 28. Clinical Pathology, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ. 29. Pathology, State University of New York Upstate Medical University, Syracuse. 30. Pathology, West Virginia University, Morgantown. 31. Hematopathology and Laboratory Medicine, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL. 32. Pathology and Laboratory Medicine, Indiana University, Indianapolis. 33. Pathology, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ. 34. Pathology, Northwestern Memorial Hospital, Chicago, IL. 35. Pathology and Anatomical Sciences, University at Buffalo-The State University of New York.
Abstract
OBJECTIVES: To assess bone marrow (BM) sampling in academic medical centers. METHODS: Data from 6,374 BM samples obtained in 32 centers in 2001 and 2011, including core length (CL), were analyzed. RESULTS: BM included a biopsy (BMB; 93%) specimen, aspirate (BMA; 92%) specimen, or both (83%). The median (SD) CL was 12 (8.5) mm, and evaluable marrow was 9 (7.6) mm. Tissue contraction due to processing was 15%. BMB specimens were longer in adults younger than 60 years, men, and bilateral, staging, and baseline samples. Only 4% of BMB and 2% of BMB/BMA samples were deemed inadequate for diagnosis. BM for plasma cell dyscrasias, nonphysician operators, and ancillary studies usage increased, while bilateral sampling decreased over the decade. BM-related quality assurance programs are infrequent. CONCLUSIONS: CL is shorter than recommended and varies with patient age and sex, clinical circumstances, and center experience. While pathologists render diagnoses on most cases irrespective of CL, BMB yield improvement is desirable.
OBJECTIVES: To assess bone marrow (BM) sampling in academic medical centers. METHODS: Data from 6,374 BM samples obtained in 32 centers in 2001 and 2011, including core length (CL), were analyzed. RESULTS: BM included a biopsy (BMB; 93%) specimen, aspirate (BMA; 92%) specimen, or both (83%). The median (SD) CL was 12 (8.5) mm, and evaluable marrow was 9 (7.6) mm. Tissue contraction due to processing was 15%. BMB specimens were longer in adults younger than 60 years, men, and bilateral, staging, and baseline samples. Only 4% of BMB and 2% of BMB/BMA samples were deemed inadequate for diagnosis. BM for plasma cell dyscrasias, nonphysician operators, and ancillary studies usage increased, while bilateral sampling decreased over the decade. BM-related quality assurance programs are infrequent. CONCLUSIONS: CL is shorter than recommended and varies with patient age and sex, clinical circumstances, and center experience. While pathologists render diagnoses on most cases irrespective of CL, BMB yield improvement is desirable.
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