Literature DB >> 30051425

Nanoparticles for Targeted Drug Delivery to Cancer Stem Cells and Tumor.

Hai Wang1, Xiaoming He2.   

Abstract

Due to the drug resistance of cancer stem cells (CSCs), CSC-targeted delivery of multiple drugs in nanoparticle-based drug delivery system holds great potential for the destruction of the CSCs and Tumor. In this chapter, we describe the preparation of multi-layered pH-responsive polymeric nanoparticles (NPs) by multiple emulsifications to encapsulate multiple hydrophilic and hydrophobic theranostic agents for controlled and sequenced release. Hyaluronic acid (HA) is used for not only actively targeting the CSCs to reduce their drug resistance due to dormancy (i.e., slow metabolism), but also replacing the commonly used poly (vinyl alcohol) (PVA) as a stabilizing agent to synthesize the nanoparticles.

Entities:  

Keywords:  Active targeting; Cancer stem cells; Combination therapy; Controlled release; Nanoparticles; Polymer; Responsiveness

Mesh：

Substances：

Year:  2018        PMID： 30051425      PMCID： PMC6151126          DOI： 10.1007/978-1-4939-8661-3_6

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  17 in total

1.  Chitosan-Decorated Doxorubicin-Encapsulated Nanoparticle Targets and Eliminates Tumor Reinitiating Cancer Stem-like Cells.

Authors:  Wei Rao; Hai Wang; Jianfeng Han; Shuting Zhao; Jenna Dumbleton; Pranay Agarwal; Wujie Zhang; Gang Zhao; Jianhua Yu; Debra L Zynger; Xiongbin Lu; Xiaoming He
Journal:  ACS Nano       Date:  2015-05-29       Impact factor: 15.881

2.  Targeting of CD44 eradicates human acute myeloid leukemic stem cells.

Authors:  Liqing Jin; Kristin J Hope; Qiongli Zhai; Florence Smadja-Joffe; John E Dick
Journal:  Nat Med       Date:  2006-09-24       Impact factor: 53.440

Review 3.  Tumour stem cells and drug resistance.

Authors:  Michael Dean; Tito Fojo; Susan Bates
Journal:  Nat Rev Cancer       Date:  2005-04       Impact factor: 60.716

4.  Block copolymer micelles for drug delivery: design, characterization and biological significance.

Authors:  K Kataoka; A Harada; Y Nagasaki
Journal:  Adv Drug Deliv Rev       Date:  2001-03-23       Impact factor: 15.470

5.  Enhanced anti-tumor efficacy by co-delivery of doxorubicin and paclitaxel with amphiphilic methoxy PEG-PLGA copolymer nanoparticles.

Authors:  Hai Wang; Ying Zhao; Yan Wu; Yu-lin Hu; Kaihui Nan; Guangjun Nie; Hao Chen
Journal:  Biomaterials       Date:  2011-07-31       Impact factor: 12.479

Review 6.  The cancer stem cell: premises, promises and challenges.

Authors:  Hans Clevers
Journal:  Nat Med       Date:  2011-03       Impact factor: 53.440

Review 7.  Multiple drug resistance in cancer revisited: the cancer stem cell hypothesis.

Authors:  Vera S Donnenberg; Albert D Donnenberg
Journal:  J Clin Pharmacol       Date:  2005-08       Impact factor: 3.126

8.  Influence of experimental parameters on the characteristics of poly(lactic acid) nanoparticles prepared by a double emulsion method.

Authors:  M F Zambaux; F Bonneaux; R Gref; P Maincent; E Dellacherie; M J Alonso; P Labrude; C Vigneron
Journal:  J Control Release       Date:  1998-01-02       Impact factor: 9.776

Review 9.  The increasing complexity of the cancer stem cell paradigm.

Authors:  Jeffrey M Rosen; Craig T Jordan
Journal:  Science       Date:  2009-06-26       Impact factor: 47.728

10.  Nodal/Activin signaling drives self-renewal and tumorigenicity of pancreatic cancer stem cells and provides a target for combined drug therapy.

Authors:  Enza Lonardo; Patrick C Hermann; Maria-Theresa Mueller; Stephan Huber; Anamaria Balic; Irene Miranda-Lorenzo; Sladjana Zagorac; Sonia Alcala; Iker Rodriguez-Arabaolaza; Juan Carlos Ramirez; Raul Torres-Ruíz; Elena Garcia; Manuel Hidalgo; David Álvaro Cebrián; Rainer Heuchel; Matthias Löhr; Frank Berger; Peter Bartenstein; Alexandra Aicher; Christopher Heeschen
Journal:  Cell Stem Cell       Date:  2011-11-04       Impact factor: 24.633
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