Aaron J Plys1,2, Robert E Kingston3,2. 1. Department of Molecular Biology and MGH Research Institute, Massachusetts General Hospital (MGH), Boston, MA, USA. 2. Department of Genetics, Harvard Medical School, Boston, MA, USA. 3. Department of Molecular Biology and MGH Research Institute, Massachusetts General Hospital (MGH), Boston, MA, USA. kingston@molbio.mgh.harvard.edu.