Literature DB >> 3004732

The adrenal: a new target organ of the calciotropic hormone 1,25-dihydroxyvitamin D3.

S A Clark, W E Stumpf, C W Bishop, H F DeLuca, D H Park, T H Joh.   

Abstract

Target cells for 1,25-dihydroxyvitamin D3 were demonstrated in the adrenal medulla by frozen-section autoradiography. The appearance of these target cells was age-dependent in neonatal mice. Immunocytochemical staining for phenylethanolamine-N-methyltransferase revealed that both epinephrine and non-epinephrine cells concentrate 1,25-dihydroxyvitamin D3 in their nuclei. In contrast, immunocytochemical staining for "vitamin D-dependent calcium-binding protein" (D-CaBP) demonstrated that D-CaBP immunoreactivity is localized in only a small percentage of adrenomedullary cells, in mice and rats. Comparison of PNMT and D-CaBP immunoreactivities in sequential sections showed that epinephrine-producing cells do not contain D-CaBP. These results indicate that adrenal medullary cells have receptors for 1,25-dihydroxyvitamin D3 and that 1,25-dihydroxyvitamin D3 may directly affect certain functions of these endocrine cells.

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Year:  1986        PMID： 3004732     DOI： 10.1007/bf00251043

Source DB:  PubMed          Journal:  Cell Tissue Res        ISSN： 0302-766X            Impact factor:   5.249


  34 in total

1.  Autoradiographic techniques for localizing steroid hormones.

Authors:  W E Stumpf; M Sar
Journal:  Methods Enzymol       Date:  1975       Impact factor: 1.600

2.  Biological activity of 25-hydroxyergocalciferol in rats.

Authors:  T Suda; H F DeLuca; Y Tanaka
Journal:  J Nutr       Date:  1970-09       Impact factor: 4.798

3.  Studies on the mode of action of calciferol. XIII. Development of a radioimmunoassay for vitamin D-dependent chick intestinal calcium-binding protein and tissue distribution.

Authors:  S Christakos; E J Friedlander; B R Frandsen; A W Norman
Journal:  Endocrinology       Date:  1979-05       Impact factor: 4.736

4.  Stimulation of specific 1,25-dihydroxyvitamin D3 binding protein in cultured postnatal rat intestine by hydrocortisone.

Authors:  E R Massaro; R U Simpson; H F DeLuca
Journal:  J Biol Chem       Date:  1982-11-25       Impact factor: 5.157

5.  Immunocytochemistry of vitamin D-dependent calcium binding protein in chick pancreas: exclusive localization.

Authors:  J Roth; S Bonner-Weir; A W Norman; L Orci
Journal:  Endocrinology       Date:  1982-06       Impact factor: 4.736

6.  Target cells for 1,25-dihydroxyvitamin D3 in intestinal tract, stomach, kidney, skin, pituitary, and parathyroid.

Authors:  W E Stumpf; M Sar; F A Reid; Y Tanaka; H F DeLuca
Journal:  Science       Date:  1979-12-07       Impact factor: 47.728

7.  Characterization of a receptor-like protein for 1,25-dihydroxyvitamin D3 in rat skin.

Authors:  R U Simpson; H F DeLuca
Journal:  Proc Natl Acad Sci U S A       Date:  1980-10       Impact factor: 11.205

8.  Topographical and developmental studies on target sites of 1,25 (OH)2 vitamin D3 in skin.

Authors:  W E Stumpf; S A Clark; M Sar; H F DeLuca
Journal:  Cell Tissue Res       Date:  1984       Impact factor: 5.249

9.  Thyrotropes in the pituitary are target cells for 1,25 dihydroxy vitamin D3.

Authors:  M Sar; W E Stumpf; H F DeLuca
Journal:  Cell Tissue Res       Date:  1980       Impact factor: 5.249

10.  Autoradiographic studies with 3H 1,25 (OH)2 vitamin D2 and 3H 25 (OH) vitamin D3 in rat parathyroid glands.

Authors:  W E Stumpf; M Sar; F A Reid; S Huang; R Narbaitz; H F DeLuca
Journal:  Cell Tissue Res       Date:  1981       Impact factor: 5.249
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  9 in total

Review 1.  Vitamin D sites and mechanisms of action: a histochemical perspective. Reflections on the utility of autoradiography and cytopharmacology for drug targeting.

Authors:  W E Stumpf
Journal:  Histochem Cell Biol       Date:  1995-12       Impact factor: 4.304

2.  1,25 (OH)2 vitamin D3 sites of action in the brain. An autoradiographic study.

Authors:  W E Stumpf; L P O'Brien
Journal:  Histochemistry       Date:  1987

3.  Sertoli cells in the testis and epithelium of the ductuli efferentes are targets for 3H 1,25 (OH)2 vitamin D3. An autoradiographic study.

Authors:  W E Stumpf; M Sar; K Chen; J Morin; H F DeLuca
Journal:  Cell Tissue Res       Date:  1987-02       Impact factor: 5.249

4.  1,25(OH)2 vitamin D3 sites of action in spinal cord and sensory ganglion.

Authors:  W E Stumpf; S A Clark; L P O'Brien; F A Reid
Journal:  Anat Embryol (Berl)       Date:  1988

Review 5.  Steroid hormones and the cardiovascular system: direct actions of estradiol, progesterone, testosterone, gluco- and mineralcorticoids, and soltriol [vitamin D] on central nervous regulatory and peripheral tissues.

Authors:  W E Stumpf
Journal:  Experientia       Date:  1990-01-15

6.  Calbindin 28 kDa in endocrine cells of known or putative calcium-regulating function. Thyro-parathyroid C cells, gastric ECL cells, intestinal secretin and enteroglucagon cells, pancreatic glucagon, insulin and PP cells, adrenal medullary NA cells and some pituitary (TSH?) cells.

Authors:  R Buffa; P Mare; M Salvadore; E Solcia; J B Furness; D E Lawson
Journal:  Histochemistry       Date:  1989

Review 7.  Vitamin D--soltriol the heliogenic steroid hormone: somatotrophic activator and modulator. Discoveries from histochemical studies lead to new concepts.

Authors:  W E Stumpf
Journal:  Histochemistry       Date:  1988

8.  Nuclear receptor sites for vitamin D-soltriol in midbrain and hindbrain of Siberian hamster (Phodopus sungorus) assessed by autoradiography.

Authors:  W E Stumpf; H J Bidmon; L Li; C Pilgrim; A Bartke; A Mayerhofer; C Heiss
Journal:  Histochemistry       Date:  1992-10

Review 9.  Light, vitamin D and psychiatry. Role of 1,25 dihydroxyvitamin D3 (soltriol) in etiology and therapy of seasonal affective disorder and other mental processes.

Authors:  W E Stumpf; T H Privette
Journal:  Psychopharmacology (Berl)       Date:  1989       Impact factor: 4.530
  9 in total

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