Wei-Jie Guan1,2, Yang Peng1,2, Xiao-Xue Zi2,3, Kai Sen Tan2, Ting-Ting He2, Nan-Shan Zhong4, De Yun Wang5. 1. State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, 151 Yanjiang Road, Guangzhou, Guangdong, China. 2. Department of Otolaryngology, Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Rd, Singapore, 119228, Singapore. 3. Department of Otolaryngology, The Second Hospital of Shandong University, Jinan, China. 4. State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, 151 Yanjiang Road, Guangzhou, Guangdong, China. nanshan@vip.163.com. 5. Department of Otolaryngology, Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Rd, Singapore, 119228, Singapore. entwdy@nus.edu.sg.
Abstract
PURPOSE OF REVIEW: Impaired mucociliary clearance has been implicated in chronic upper and lower airway inflammatory diseases (i.e., allergic and non-allergic rhinitis, chronic rhinosinusitis with or without nasal polyps and asthma). How motile ciliary disorders (impaired ciliogenesis, ciliary beating and ultrastructural defects) are implicated in chronic airway inflammatory diseases is not fully understood. Elaboration of the role of motile ciliary disorders may serve as therapeutic targets for improving mucociliary clearance, thereby complementing contemporary disease management. RECENT FINDINGS: We have summarized the manifestations of motile ciliary disorders and addressed the underlying associations with chronic airway inflammatory diseases. A panel of established and novel diagnostic tests and therapeutic interventions are outlined. Physicians should be vigilant in screening for motile ciliary disorders, particularly in patients with co-existing upper and lower airway inflammatory diseases. Proper assessment and treatment of motile ciliary disorders may have added value to the management and prevention of chronic airway inflammatory diseases.
PURPOSE OF REVIEW: Impaired mucociliary clearance has been implicated in chronic upper and lower airway inflammatory diseases (i.e., allergic and non-allergic rhinitis, chronic rhinosinusitis with or without nasal polyps and asthma). How motile ciliary disorders (impaired ciliogenesis, ciliary beating and ultrastructural defects) are implicated in chronic airway inflammatory diseases is not fully understood. Elaboration of the role of motile ciliary disorders may serve as therapeutic targets for improving mucociliary clearance, thereby complementing contemporary disease management. RECENT FINDINGS: We have summarized the manifestations of motile ciliary disorders and addressed the underlying associations with chronic airway inflammatory diseases. A panel of established and novel diagnostic tests and therapeutic interventions are outlined. Physicians should be vigilant in screening for motile ciliary disorders, particularly in patients with co-existing upper and lower airway inflammatory diseases. Proper assessment and treatment of motile ciliary disorders may have added value to the management and prevention of chronic airway inflammatory diseases.
Authors: Heike Olbrich; Miriam Schmidts; Claudius Werner; Alexandros Onoufriadis; Niki T Loges; Johanna Raidt; Nora Fanni Banki; Amelia Shoemark; Tom Burgoyne; Saeed Al Turki; Matthew E Hurles; Gabriele Köhler; Josef Schroeder; Gudrun Nürnberg; Peter Nürnberg; Eddie M K Chung; Richard Reinhardt; June K Marthin; Kim G Nielsen; Hannah M Mitchison; Heymut Omran Journal: Am J Hum Genet Date: 2012-09-27 Impact factor: 11.025
Authors: Kai Sen Tan; Hsiao Hui Ong; Yan Yan; Jing Liu; Chunwei Li; Yew Kwang Ong; Kim Thye Thong; Hyung Won Choi; De-Yun Wang; Vincent T Chow Journal: J Infect Dis Date: 2018-03-05 Impact factor: 5.226
Authors: Jane S Lucas; Angelo Barbato; Samuel A Collins; Myrofora Goutaki; Laura Behan; Daan Caudri; Sharon Dell; Ernst Eber; Estelle Escudier; Robert A Hirst; Claire Hogg; Mark Jorissen; Philipp Latzin; Marie Legendre; Margaret W Leigh; Fabio Midulla; Kim G Nielsen; Heymut Omran; Jean-Francois Papon; Petr Pohunek; Beatrice Redfern; David Rigau; Bernhard Rindlisbacher; Francesca Santamaria; Amelia Shoemark; Deborah Snijders; Thomy Tonia; Andrea Titieni; Woolf T Walker; Claudius Werner; Andrew Bush; Claudia E Kuehni Journal: Eur Respir J Date: 2017-01-04 Impact factor: 16.671
Authors: Myrofora Goutaki; Elisabeth Maurer; Florian S Halbeisen; Israel Amirav; Angelo Barbato; Laura Behan; Mieke Boon; Carmen Casaulta; Annick Clement; Suzanne Crowley; Eric Haarman; Claire Hogg; Bulent Karadag; Cordula Koerner-Rettberg; Margaret W Leigh; Michael R Loebinger; Henryk Mazurek; Lucy Morgan; Kim G Nielsen; Heymut Omran; Nicolaus Schwerk; Sergio Scigliano; Claudius Werner; Panayiotis Yiallouros; Zorica Zivkovic; Jane S Lucas; Claudia E Kuehni Journal: Eur Respir J Date: 2017-01-04 Impact factor: 16.671
Authors: Colin R Butler; Robert E Hynds; Kate H C Gowers; Dani Do Hyang Lee; James M Brown; Claire Crowley; Vitor H Teixeira; Claire M Smith; Luca Urbani; Nicholas J Hamilton; Ricky M Thakrar; Helen L Booth; Martin A Birchall; Paolo De Coppi; Adam Giangreco; Christopher O'Callaghan; Sam M Janes Journal: Am J Respir Crit Care Med Date: 2016-07-15 Impact factor: 21.405
Authors: Claire L Jackson; Laura Behan; Samuel A Collins; Patricia M Goggin; Elizabeth C Adam; Janice L Coles; Hazel J Evans; Amanda Harris; Peter Lackie; Samantha Packham; Anton Page; James Thompson; Woolf T Walker; Claudia Kuehni; Jane S Lucas Journal: Eur Respir J Date: 2015-12-02 Impact factor: 16.671
Authors: Kai Sen Tan; Rachel Liyu Lim; Jing Liu; Hsiao Hui Ong; Vivian Jiayi Tan; Hui Fang Lim; Kian Fan Chung; Ian M Adcock; Vincent T Chow; De Yun Wang Journal: Front Cell Dev Biol Date: 2020-02-25