BACKGROUND: The neurocognitive trajectory in bipolar disorder (BD) is variable, with controversial findings, and most evidence come from cross-sectional studies. We aimed to examine the course of neurocognitive functioning in a sample of euthymic BD patients in comparison with a control group during a 5-year follow-up. METHODS: Ninety-nine euthymic bipolar patients and 40 healthy controls were assessed using a comprehensive neurocognitive battery (six neurocognitive domains) at baseline (T1) and then at 5-year follow-up (T2) in a longitudinal study. RESULTS: No evidence of a progression in neurocognitive dysfunction was found either in cognitive composite index or in any of the neurocognitive domains for the whole cohort. However, there was a negative correlation between number of manic episodes and hospitalisations due to manic episodes and change in neurocognitive composite index (NCI) during the follow-up. Moreover, patients with higher number of manic and hypomanic episodes have a greater decrease in NCI, working memory and visual memory. History of psychotic symptoms was not related to the trajectory of neurocognitive impairment. CONCLUSIONS: Our results suggest that, although the progression of cognitive decline is not a general rule in BD, BD patients who have a greater number of manic or hypomanic episodes may constitute a subgroup characterised by the progression of neurocognitive impairment. Prevention of manic and hypomanic episodes could have a positive impact on the trajectory of cognitive function.
BACKGROUND: The neurocognitive trajectory in bipolar disorder (BD) is variable, with controversial findings, and most evidence come from cross-sectional studies. We aimed to examine the course of neurocognitive functioning in a sample of euthymic BDpatients in comparison with a control group during a 5-year follow-up. METHODS: Ninety-nine euthymic bipolarpatients and 40 healthy controls were assessed using a comprehensive neurocognitive battery (six neurocognitive domains) at baseline (T1) and then at 5-year follow-up (T2) in a longitudinal study. RESULTS: No evidence of a progression in neurocognitive dysfunction was found either in cognitive composite index or in any of the neurocognitive domains for the whole cohort. However, there was a negative correlation between number of manic episodes and hospitalisations due to manic episodes and change in neurocognitive composite index (NCI) during the follow-up. Moreover, patients with higher number of manic and hypomanic episodes have a greater decrease in NCI, working memory and visual memory. History of psychotic symptoms was not related to the trajectory of neurocognitive impairment. CONCLUSIONS: Our results suggest that, although the progression of cognitive decline is not a general rule in BD, BDpatients who have a greater number of manic or hypomanic episodes may constitute a subgroup characterised by the progression of neurocognitive impairment. Prevention of manic and hypomanic episodes could have a positive impact on the trajectory of cognitive function.
Authors: Eileen P Ahearn; Benjamin R Szymanski; Peijun Chen; Martha Sajatovic; Ira R Katz; John F McCarthy Journal: Psychiatr Serv Date: 2020-06-10 Impact factor: 3.084
Authors: Kamilla W Miskowiak; Ida Seeberg; Mette B Jensen; Vicent Balanzá-Martínez; Caterina Del Mar Bonnin; Christopher R Bowie; Andre F Carvalho; Annemieke Dols; Katie Douglas; Peter Gallagher; Gregor Hasler; Beny Lafer; Kathryn E Lewandowski; Carlos López-Jaramillo; Anabel Martinez-Aran; Roger S McIntyre; Richard J Porter; Scot E Purdon; Ayal Schaffer; Paul Stokes; Tomiki Sumiyoshi; Ivan J Torres; Tamsyn E Van Rheenen; Lakshmi N Yatham; Allan H Young; Lars V Kessing; Katherine E Burdick; Eduard Vieta Journal: Bipolar Disord Date: 2022-02-24 Impact factor: 5.345
Authors: Tobin J Ehrlich; Kelly A Ryan; Katherine E Burdick; Scott A Langenecker; Melvin G McInnis; David F Marshall Journal: Acta Psychiatr Scand Date: 2022-06-25 Impact factor: 7.734