Faina Linkov1,2,3, Sharon L Goughnour1, Shalkar Adambekov2, Anna Lokshin4, Joseph L Kelley5, Paniti Sukumvanich5, John T Comerci5, Kacey G Marra6, Lauren E Kokai6, J Peter Rubin6, Anda M Vlad1, Brian J Philips1, Robert P Edwards1,3. 1. Department of Obstetrics, Gynecology, & Reproductive Sciences, Magee-Womens Research Institute, University of Pittsburgh, 3380 Blvd of the Allies, Pittsburgh, PA 15213, USA. 2. Department of Epidemiology, University of Pittsburgh, 130 De Soto Street, Pittsburgh, PA 15216, USA. 3. UPMC Hillman Cancer Center, 5115 Centre Avenue Pittsburgh, PA 15232, USA. 4. Department of Medicine, UPMC Cancer Pavilion, 5150 Centre Avenue, Pittsburgh, PA 15232, USA. 5. Division of Gynecologic Oncology, Department of Obstetrics, Gynecology & Reproductive Sciences, University of Pittsburgh School of Medicine, Magee-Womens Hospital, 300 Halket Street, Pittsburgh, PA 15213, USA. 6. Department of Plastic Surgery, University of Pittsburgh School of Medicine, 3550 Terrace Street, Scaife Hall, Pittsburgh, PA 15261, USA.
Abstract
AIM: To explore inflammatory biomarkers secreted by adipose stem cells (ASCs) in omental, retroperitoneal and subcutaneous adipose tissues of women with endometrial cancer. PATIENTS & METHODS: ASCs were collected from 22 women, aged 35-83 years, undergoing hysterectomy for endometrial cancer. Angiopoietin-2, EGF, IL-8, leptin, VEGFA, VEGFC and VEFGD levels in the ASC-conditioned media were analyzed by Luminex. RESULTS: We found a significant difference between the three depots for IL-8 (p < 0.0001), with the highest levels of IL-8 in the omental depot. VEGFA levels were highest in the retroperitoneal depot. CONCLUSION: This is one of the first studies to explore biomarker expression in ASC-conditioned media in adipose tissue. ASC characteristics may be important to evaluate in relation to cancer risk.
AIM: To explore inflammatory biomarkers secreted by adipose stem cells (ASCs) in omental, retroperitoneal and subcutaneous adipose tissues of women with endometrial cancer. PATIENTS & METHODS: ASCs were collected from 22 women, aged 35-83 years, undergoing hysterectomy for endometrial cancer. Angiopoietin-2, EGF, IL-8, leptin, VEGFA, VEGFC and VEFGD levels in the ASC-conditioned media were analyzed by Luminex. RESULTS: We found a significant difference between the three depots for IL-8 (p < 0.0001), with the highest levels of IL-8 in the omental depot. VEGFA levels were highest in the retroperitoneal depot. CONCLUSION: This is one of the first studies to explore biomarker expression in ASC-conditioned media in adipose tissue. ASC characteristics may be important to evaluate in relation to cancer risk.
Authors: James B Mitchell; Kevin McIntosh; Sanjin Zvonic; Sara Garrett; Z Elizabeth Floyd; Amy Kloster; Yuan Di Halvorsen; Robert W Storms; Brian Goh; Gail Kilroy; Xiying Wu; Jeffrey M Gimble Journal: Stem Cells Date: 2005-12-01 Impact factor: 6.277
Authors: M Aamir Sheikh; Andrew D Althouse; Kyle E Freese; Sean Soisson; Robert P Edwards; Sharon Welburn; Paniti Sukumvanich; John Comerci; Joseph Kelley; Ronald E LaPorte; Faina Linkov Journal: Future Oncol Date: 2014-12 Impact factor: 3.404
Authors: Lauren E Kokai; Dmitry O Traktuev; Liyong Zhang; Stephanie Merfeld-Clauss; Gabriella DiBernardo; Hongyan Lu; Kacey G Marra; Albert Donnenberg; Vera Donnenberg; E Michael Meyer; Peter B Fodor; Keith L March; J Peter Rubin Journal: Aesthet Surg J Date: 2017-04-01 Impact factor: 4.283
Authors: John N Fain; Harold S Sacks; Suleiman W Bahouth; David S Tichansky; Atul K Madan; Paramjeet S Cheema Journal: Metabolism Date: 2010-02-01 Impact factor: 8.694
Authors: Faina Linkov; Sharon L Goughnour; Robert P Edwards; Anna Lokshin; Ramesh C Ramanathan; Giselle G Hamad; Carol McCloskey; Dana H Bovbjerg Journal: Surg Obes Relat Dis Date: 2017-01-13 Impact factor: 4.734
Authors: S J Bigornia; M G Farb; M M Mott; D T Hess; B Carmine; A Fiscale; L Joseph; C M Apovian; N Gokce Journal: Nutr Diabetes Date: 2012-03-05 Impact factor: 5.097