Literature DB >> 30042904

Design of a Precision Medication Dispenser: Preventing Overdose by Increasing Accuracy and Precision of Dosage.

Shriya S Srinivasan1, Sai N R Kantareddy2, Ebenezer A Nkwate3, Praveen Meka4, Ivy Chang2, Nevan C Hanumara2, Khalil B Ramadi1.   

Abstract

Liquid medication overdose in pediatric patients results in over 70000 visits to the emergency room yearly in the USA. Various studies have demonstrated that the root cause of this high incidence is due to user and device error in dose measurement. The standard measuring cup and syringe suffer from the challenge of accurately measuring and dispensing viscous liquids, which comprise the majority of children's medication formulations. Here, we describe the development of a precision medication dispenser that overcomes challenges associated with viscous fluid flow at low volumes and flow rates, while incorporating various ergonomic and user-friendly features. The device performs with >95% accuracy and 94% precision across the 1-5-mL range of volume, a significant improvement when compared to current commercially available dispensers.

Entities:  

Keywords:  Liquid medication; administration error; dosage; overdose; viscous flow

Year:  2018        PMID: 30042904      PMCID: PMC6054514          DOI: 10.1109/JTEHM.2018.2842223

Source DB:  PubMed          Journal:  IEEE J Transl Eng Health Med        ISSN: 2168-2372            Impact factor:   3.316


  17 in total

Review 1.  Medication errors: causes, prevention and reduction.

Authors:  Jonathan Allard; Jane Carthey; Judith Cope; Matthew Pitt; Suzette Woodward
Journal:  Br J Haematol       Date:  2002-02       Impact factor: 6.998

2.  Acetaminophen overdose in children.

Authors:  Jacqueline D Ogilvie; Michael J Rieder; Rodrick Lim
Journal:  CMAJ       Date:  2012-06-04       Impact factor: 8.262

3.  Medication errors and adverse drug events in pediatric inpatients.

Authors:  R Kaushal; D W Bates; C Landrigan; K J McKenna; M D Clapp; F Federico; D A Goldmann
Journal:  JAMA       Date:  2001-04-25       Impact factor: 56.272

4.  Appropriateness of oral medication delivery devices available in community pharmacies.

Authors:  Brooke L Gildon; Michelle Condren; Christina Phillips; Allyson Votruba; Sajidah Swar
Journal:  J Am Pharm Assoc (2003)       Date:  2016 Mar-Apr

5.  Inadvertent ketamine overdose in children: clinical manifestations and outcome.

Authors:  S M Green; R Clark; M A Hostetler; M Cohen; D Carlson; S G Rothrock
Journal:  Ann Emerg Med       Date:  1999-10       Impact factor: 5.721

6.  Medication Errors in Outpatient Pediatrics.

Authors:  Kyla Berrier
Journal:  MCN Am J Matern Child Nurs       Date:  2016 Sep-Oct       Impact factor: 1.412

7.  Acetaminophen toxicity in children.

Authors: 
Journal:  Pediatrics       Date:  2001-10       Impact factor: 7.124

8.  Women's understanding of different dosing instructions for a liquid pediatric medication.

Authors:  Lorraine S Wallace; Amy J Keenum; Jennifer E DeVoe; Shannon K Bolon; Julie S Hansen
Journal:  J Pediatr Health Care       Date:  2011-08-06       Impact factor: 1.812

9.  Accuracy and precision of manufacturer-supplied liquid medication administration devices before and after patient education.

Authors:  Gina Peacock; Sarah Parnapy; Shelby Raynor; Stewart Wetmore
Journal:  J Am Pharm Assoc (2003)       Date:  2010 Jan-Feb

10.  Xylometazoline poisoning: A 40-fold nasal overdose caused by a compounding error in 3 children.

Authors:  Frank Musshoff; Burkhard Madea; Joachim Woelfle; Dejan Vlanic
Journal:  Forensic Sci Int       Date:  2014-02-20       Impact factor: 2.395

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