INTRODUCTION: Contribution of cerebral microbleeds (CMBs) on cognitive dysfunctions in elderly patients with otherwise asymptomatic white matter lesions (WMLs) is not well-documented. METHODS: MRI parameters of cerebral atrophy, CMBs and WMLs were herein analyzed in relation to global and main domains (attention, executive, memory, visuospatial, language) of cognitive function. Eighty-five patients older than 50, without neurodegenerative/cerebrovascular disease, but had CMBs were recruited from 2562 with T2*-gradient-echo MR imaging during one-year period. RESULTS: Global cognition, evaluated by mini-mental status examination (MMSE), was impaired (score ≤24) in 42%. In contrast to CMBs load, WML burden and temporal atrophy were significantly higher in cases with MMSE≤24. Cholinergic Pathways HyperIntensities Scale (CHIPS) was positively correlated with global cognitive dysfunction but its CMB counterpart, Cholinergic Pathways Bleeding Scale described herein, was not. However, burden of CMBs in thalamic/cortical regions predicted language dysfunction. CONCLUSION: Cognitive dysfunction associated with CMBs may be dependent on their distribution rather than their absolute number.
INTRODUCTION: Contribution of cerebral microbleeds (CMBs) on cognitive dysfunctions in elderly patients with otherwise asymptomatic white matter lesions (WMLs) is not well-documented. METHODS: MRI parameters of cerebral atrophy, CMBs and WMLs were herein analyzed in relation to global and main domains (attention, executive, memory, visuospatial, language) of cognitive function. Eighty-five patients older than 50, without neurodegenerative/cerebrovascular disease, but had CMBs were recruited from 2562 with T2*-gradient-echo MR imaging during one-year period. RESULTS: Global cognition, evaluated by mini-mental status examination (MMSE), was impaired (score ≤24) in 42%. In contrast to CMBs load, WML burden and temporal atrophy were significantly higher in cases with MMSE≤24. Cholinergic Pathways HyperIntensities Scale (CHIPS) was positively correlated with global cognitive dysfunction but its CMB counterpart, Cholinergic Pathways Bleeding Scale described herein, was not. However, burden of CMBs in thalamic/cortical regions predicted language dysfunction. CONCLUSION: Cognitive dysfunction associated with CMBs may be dependent on their distribution rather than their absolute number.
Entities:
Keywords:
Cholinergic; cortex; cortical; dementia; gradient echo; lacune; magnetic resonance imaging; microbleed; white matter
Authors: Franz Fazekas; F Barkhof; L O Wahlund; L Pantoni; T Erkinjuntti; P Scheltens; R Schmidt Journal: Cerebrovasc Dis Date: 2002 Impact factor: 2.762
Authors: J D C Goos; W J P Henneman; J D Sluimer; H Vrenken; I C Sluimer; F Barkhof; M A Blankenstein; P H Scheltens; W M van der Flier Journal: Neurology Date: 2010-06-15 Impact factor: 9.910
Authors: Charlotte Cordonnier; Gillian M Potter; Caroline A Jackson; Fergus Doubal; Sarah Keir; Cathie L M Sudlow; Joanna M Wardlaw; Rustam Al-Shahi Salman Journal: Stroke Date: 2008-11-13 Impact factor: 7.914
Authors: Wai Kwong Tang; Yang-Kun Chen; Jin-Yan Lu; Adrian Wong; Vincent Mok; Winnie C W Chu; Gabor S Ungvari; Ka Sing Wong Journal: Int J Stroke Date: 2011-12 Impact factor: 5.266
Authors: Christian Bocti; Richard H Swartz; Fu-Qiang Gao; Demetrios J Sahlas; Pearl Behl; Sandra E Black Journal: Stroke Date: 2005-09-22 Impact factor: 7.914
Authors: Karlijn F de Laat; Heleen A C van den Berg; Anouk G W van Norden; Rob A R Gons; Marcel G M Olde Rikkert; Frank-Erik de Leeuw Journal: Stroke Date: 2010-12-16 Impact factor: 7.914
Authors: F Fazekas; R Kleinert; G Roob; G Kleinert; P Kapeller; R Schmidt; H P Hartung Journal: AJNR Am J Neuroradiol Date: 1999-04 Impact factor: 3.825
Authors: Michel Bilello; Jimit Doshi; S Ali Nabavizadeh; Jon B Toledo; Guray Erus; Sharon X Xie; John Q Trojanowski; Xiaoyan Han; Christos Davatzikos Journal: J Alzheimers Dis Date: 2015 Impact factor: 4.472