BACKGROUND AND PURPOSE: Cerebral small vessel disease (SVD), including white matter lesions and lacunar infarcts, is related to gait disturbances. Microbleeds (MB) are another manifestation of SVD, but their clinical impact remains unclear. We therefore investigated the relation between the number and location of MB and gait, independently of white matter lesions and lacunar infarcts. METHODS: MRI scanning was performed in 485 nondemented elderly individuals with cerebral SVD. The number and location of MB were rated. Gait was assessed with a GAITRite system and the Tinetti and Timed-Up-and-Go tests. MB were related to gait parameters by age, height, total brain volume, white matter lesions, and number of lacunar infarcts-adjusted linear regression. RESULTS: A higher number of MB was independently related to a shorter stride length and poorer performance on the Tinetti and Timed-Up-and-Go tests. These relations seemed to be explained by MB in the temporal and frontal lobe and basal ganglia, including the thalamus. CONCLUSIONS: This study offers the first indication that MB may be associated with gait disturbances, independently of other coexisting markers of SVD.
BACKGROUND AND PURPOSE:Cerebral small vessel disease (SVD), including white matter lesions and lacunar infarcts, is related to gait disturbances. Microbleeds (MB) are another manifestation of SVD, but their clinical impact remains unclear. We therefore investigated the relation between the number and location of MB and gait, independently of white matter lesions and lacunar infarcts. METHODS: MRI scanning was performed in 485 nondemented elderly individuals with cerebral SVD. The number and location of MB were rated. Gait was assessed with a GAITRite system and the Tinetti and Timed-Up-and-Go tests. MB were related to gait parameters by age, height, total brain volume, white matter lesions, and number of lacunar infarcts-adjusted linear regression. RESULTS: A higher number of MB was independently related to a shorter stride length and poorer performance on the Tinetti and Timed-Up-and-Go tests. These relations seemed to be explained by MB in the temporal and frontal lobe and basal ganglia, including the thalamus. CONCLUSIONS: This study offers the first indication that MB may be associated with gait disturbances, independently of other coexisting markers of SVD.
Authors: François De Guio; Eric Jouvent; Geert Jan Biessels; Sandra E Black; Carol Brayne; Christopher Chen; Charlotte Cordonnier; Frank-Eric De Leeuw; Martin Dichgans; Fergus Doubal; Marco Duering; Carole Dufouil; Emrah Duzel; Franz Fazekas; Vladimir Hachinski; M Arfan Ikram; Jennifer Linn; Paul M Matthews; Bernard Mazoyer; Vincent Mok; Bo Norrving; John T O'Brien; Leonardo Pantoni; Stefan Ropele; Perminder Sachdev; Reinhold Schmidt; Sudha Seshadri; Eric E Smith; Luciano A Sposato; Blossom Stephan; Richard H Swartz; Christophe Tzourio; Mark van Buchem; Aad van der Lugt; Robert van Oostenbrugge; Meike W Vernooij; Anand Viswanathan; David Werring; Frank Wollenweber; Joanna M Wardlaw; Hugues Chabriat Journal: J Cereb Blood Flow Metab Date: 2016-05-11 Impact factor: 6.200
Authors: Farzaneh A Sorond; Yenisel Cruz-Almeida; David J Clark; Anand Viswanathan; Clemens R Scherzer; Philip De Jager; Anna Csiszar; Paul J Laurienti; Jeffery M Hausdorff; Wen G Chen; Luiggi Ferrucci; Caterina Rosano; Stephanie A Studenski; Sandra E Black; Lewis A Lipsitz Journal: J Gerontol A Biol Sci Med Sci Date: 2015-09-18 Impact factor: 6.053
Authors: Peter Toth; Stefano Tarantini; Zsolt Springo; Zsuzsanna Tucsek; Tripti Gautam; Cory B Giles; Jonathan D Wren; Akos Koller; William E Sonntag; Anna Csiszar; Zoltan Ungvari Journal: Aging Cell Date: 2015-02-09 Impact factor: 9.304
Authors: Paul A Yates; Victor L Villemagne; Kathryn A Ellis; Patricia M Desmond; Colin L Masters; Christopher C Rowe Journal: Front Neurol Date: 2014-01-06 Impact factor: 4.003