Literature DB >> 30039828

2-Formylpyrrole natural products: origin, structural diversity, bioactivity and synthesis.

James M Wood1, Daniel P Furkert1, Margaret A Brimble2.   

Abstract

Covering: up to April 2018 2-Formylpyrroles are ubiquitous in nature, arising from the non-enzymatic Maillard reactions of amines and sugars. Often confused for secondary metabolites, these Maillard products display interesting biological activities including hepatoprotective, immunostimulatory, antiproliferative and antioxidant effects. This review presents all 2-formylpyrrole natural products reported to date and identifies structural sub-classes for their categorisation. The origin, biological activity and chemical syntheses of these natural products are discussed herein.

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Year:  2019        PMID： 30039828     DOI： 10.1039/c8np00051d

Source DB:  PubMed          Journal:  Nat Prod Rep        ISSN： 0265-0568            Impact factor:   13.423


  8 in total

1.  Pyrrole 2-carbaldehyde derived alkaloids from the roots of Angelica dahurica.

Authors:  Bowen Qi; Wanqing Yang; Ning Ding; Yuan Luo; Fangfang Jia; Xiao Liu; Juan Wang; Xiaohui Wang; Pengfei Tu; Shepo Shi
Journal:  J Nat Med       Date:  2019-06-17       Impact factor: 2.343

2.  Total Synthesis of Bipolamine I.

Authors:  Xiang Qiu; Joshua G Pierce
Journal:  J Am Chem Soc       Date:  2022-07-05       Impact factor: 16.383

Review 3.  Marine Pyrrole Alkaloids.

Authors:  Kevin Seipp; Leander Geske; Till Opatz
Journal:  Mar Drugs       Date:  2021-09-10       Impact factor: 5.118

4.  Ribose conversion with amino acids into pyrraline platform chemicals - expeditious synthesis of diverse pyrrole-fused alkaloid compounds.

Authors:  Soohyeon Cho; Lina Gu; Ik Joon In; Bo Wu; Taehoon Lee; Hakwon Kim; Sangho Koo
Journal:  RSC Adv       Date:  2021-09-23       Impact factor: 4.036

5.  Synthesis and reactivity of 2-thionoester pyrroles: a route to 2-formyl pyrroles.

Authors:  Min Joon Kim; Sophie M Gaube; Michael H R Beh; Craig D Smith; Alison Thompson
Journal:  RSC Adv       Date:  2019-10-07       Impact factor: 3.361

6.  Selective One-Pot Multicomponent Synthesis of N-Substituted 2,3,5-Functionalized 3-Cyanopyrroles via the Reaction between α-Hydroxyketones, Oxoacetonitriles, and Primary Amines.

Authors:  Mengxin Xia; Ziad Moussa; Zaher M A Judeh
Journal:  Molecules       Date:  2022-08-18       Impact factor: 4.927

7.  Identification of a Novel Pyrrole Alkaloid from the Edible Mushroom Basidiomycetes-X (Echigoshirayukidake).

Authors:  Toshio Sakamoto; Ayaka Nishida; Naoki Wada; Yutaka Nakamura; Shinji Sato; Tetsuya Konishi; Seiichi Matsugo
Journal:  Molecules       Date:  2020-10-22       Impact factor: 4.411

8.  Solvent Free Three-Component Synthesis of 2,4,5-trisubstituted-1H-pyrrol-3-ol-type Compounds from L-tryptophan: DFT-B3LYP Calculations for the Reaction Mechanism and 3H-pyrrol-3-one↔1H-pyrrol-3-ol Tautomeric Equilibrium.

Authors:  Diego Quiroga; Lili Dahiana Becerra; Ericsson Coy-Barrera
Journal:  Molecules       Date:  2020-09-25       Impact factor: 4.411
  8 in total

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