Literature DB >> 3002449

Synthetic substrates of vertebrate collagenase.

H Weingarten, R Martin, J Feder.   

Abstract

The active site specificity of vertebrate collagenase was mapped with the synthesis of a variety of peptides, peptolides, and peptide esters. The enzyme was found to prefer very lipophilic sequences, and it was also found to be an esterase. The thio peptolide Ac-Pro-Leu-Gly-SCH[CH2CH(CH3)2]CO-Leu-Gly-OC2H5 was found to be an exceptional substrate. High-performance liquid chromatography and tandem mass spectrometry were used to unambiguously establish the cleavage site in several peptide substrates.

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Year:  1985        PMID： 3002449     DOI： 10.1021/bi00344a064

Source DB:  PubMed          Journal:  Biochemistry        ISSN： 0006-2960            Impact factor:   3.162


  11 in total

1.  pH- and temperature-dependence of functional modulation in metalloproteinases. A comparison between neutrophil collagenase and gelatinases A and B.

Authors:  G F Fasciglione; S Marini; S D'Alessio; V Politi; M Coletta
Journal:  Biophys J       Date:  2000-10       Impact factor: 4.033

2.  The inhibitory effect of polyvinylphosphonic acid on functional matrix metalloproteinase activities in human demineralized dentin.

Authors:  Arzu Tezvergil-Mutluay; Kelli A Agee; Tomohiro Hoshika; Franklin R Tay; David H Pashley
Journal:  Acta Biomater       Date:  2010-05-23       Impact factor: 8.947

3.  Competitive inhibition of human skin collagenase by N-benzyloxycarbonyl-L-prolyl-L-alanyl-3-amino-2-oxopropyl-L-leucyl-L- alanylglycine ethyl ester.

Authors:  D A Wallace; S R Bates; B Walker; G Kay; J White; D J Guthrie; N L Blumson; D T Elmore
Journal:  Biochem J       Date:  1986-11-01       Impact factor: 3.857

4.  Matrix metalloproteinase-10 (MMP-10) interaction with tissue inhibitors of metalloproteinases TIMP-1 and TIMP-2: binding studies and crystal structure.

Authors:  Jyotica Batra; Jessica Robinson; Alexei S Soares; Alan P Fields; Derek C Radisky; Evette S Radisky
Journal:  J Biol Chem       Date:  2012-03-16       Impact factor: 5.157

5.  Sequencing and characterization of the soybean leaf metalloproteinase : structural and functional similarity to the matrix metalloproteinase family.

Authors:  G McGeehan; W Burkhart; R Anderegg; J D Becherer; J W Gillikin; J S Graham
Journal:  Plant Physiol       Date:  1992-07       Impact factor: 8.340

6.  Method to analyze collagenase and gelatinase activity by fibroblasts in culture.

Authors:  L J Gould; D R Yager; G M McGeehan; R F Diegelmann
Journal:  In Vitro Cell Dev Biol Anim       Date:  1999-02       Impact factor: 2.416

7.  A new methodology for monitoring the activity of cdMMP-12 anchored and freeze-dried on Au (111).

Authors:  Giuseppe Grasso; Marco Fragai; Enrico Rizzarelli; Giuseppe Spoto; Kwon Joo Yeo
Journal:  J Am Soc Mass Spectrom       Date:  2007-03-23       Impact factor: 3.109

8.  Effect of matrix metalloproteinase inhibitors on tumor growth and spontaneous metastasis.

Authors:  J G Conway; S J Trexler; J A Wakefield; B E Marron; D L Emerson; D M Bickett; D N Deaton; D Garrison; M Elder; A McElroy; N Willmott; A J Dockerty; G M McGeehan
Journal:  Clin Exp Metastasis       Date:  1996-03       Impact factor: 5.150

9.  Photodynamic molecular beacon as an activatable photosensitizer based on protease-controlled singlet oxygen quenching and activation.

Authors:  Gang Zheng; Juan Chen; Klara Stefflova; Mark Jarvi; Hui Li; Brian C Wilson
Journal:  Proc Natl Acad Sci U S A       Date:  2007-05-14       Impact factor: 11.205

10.  92-kD type IV collagenase mediates invasion of human cytotrophoblasts.

Authors:  C L Librach; Z Werb; M L Fitzgerald; K Chiu; N M Corwin; R A Esteves; D Grobelny; R Galardy; C H Damsky; S J Fisher
Journal:  J Cell Biol       Date:  1991-04       Impact factor: 10.539
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