Karn Wijarnpreecha1,2, Panadeekarn Panjawatanan3, Wuttiporn Manatsathit4, Wisit Cheungpasitporn5, Surakit Pungpapong2, Frank J Lukens2, Patompong Ungprasert6. 1. Department of Internal Medicine, Bassett Medical Center, Cooperstown, NY, USA. 2. Division of Gastroenterology and Hepatology, Mayo Clinic, Mayo Clinic College of Medicine, Jacksonville, FL, USA. 3. Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. 4. Department of Gastroenterology & Hepatology, University of Nebraska Medical Center, Omaha, NE, USA. 5. Department of Medicine, Division of Nephrology, University of Mississippi Medical Center, Jackson, MS, USA. 6. Clinical Epidemiology Unit, Department of Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang Road, Bangkoknoi, Bangkok, 10700, Thailand. p.ungprasert@gmail.com.
Abstract
BACKGROUND/ OBJECTIVES: Studies have suggested that the presence of juxtapapillary duodenal diverticula (JDD) could be a predisposing factor for choledocholithiasis. This systematic review and meta-analysis was conducted with the aims to summarize all available evidence to better characterize the risk. METHODS: A literature search was performed using MEDLINE and EMBASE database from inception to January 2018. Cross-sectional studies that reported odd ratios (OR) comparing the risk of choledocholithiasis among individuals with JDD versus individuals without JDD were included. Pooled OR and 95% confidence interval (CI) were calculated using a random-effect, generic inverse variance method. RESULTS: Of 527 retrieved articles, 11 studies met our eligibility criteria and were included in analysis. We found a significant association between the presence of JDD and choledocholithiasis with the pooled OR of 2.30 (95% CI, 1.84-2.86). The statistical heterogeneity was moderate with an I2 of 60%. CONCLUSIONS: A significantly increased risk of choledocholithiasis among individuals with JDD was observed in this study.
BACKGROUND/ OBJECTIVES: Studies have suggested that the presence of juxtapapillary duodenal diverticula (JDD) could be a predisposing factor for choledocholithiasis. This systematic review and meta-analysis was conducted with the aims to summarize all available evidence to better characterize the risk. METHODS: A literature search was performed using MEDLINE and EMBASE database from inception to January 2018. Cross-sectional studies that reported odd ratios (OR) comparing the risk of choledocholithiasis among individuals with JDD versus individuals without JDD were included. Pooled OR and 95% confidence interval (CI) were calculated using a random-effect, generic inverse variance method. RESULTS: Of 527 retrieved articles, 11 studies met our eligibility criteria and were included in analysis. We found a significant association between the presence of JDD and choledocholithiasis with the pooled OR of 2.30 (95% CI, 1.84-2.86). The statistical heterogeneity was moderate with an I2 of 60%. CONCLUSIONS: A significantly increased risk of choledocholithiasis among individuals with JDD was observed in this study.
Entities:
Keywords:
Choledocholithiasis; Common bile duct stone; Duodenal diverticulum; Meta-analysis; Periampullary diverticulum
Authors: E De Koster; P Denis; M Mante; J Otero; J Nyst; C Jonas; M Van Gossum; M De Reuck; M Deltenre Journal: Acta Gastroenterol Belg Date: 1990 May-Jun Impact factor: 1.316
Authors: Raúl Herzog; María José Álvarez-Pasquin; Camino Díaz; José Luis Del Barrio; José Manuel Estrada; Ángel Gil Journal: BMC Public Health Date: 2013-02-19 Impact factor: 3.295