Juan P Cata1. 1. Department of Anesthesiology and Perioperative Medicine, The University of Texas -MD Anderson Cancer Center; Anesthesia and Surgical Oncology Research Group, Houston, Texas, USA.
Abstract
PURPOSE OF REVIEW: To summarize the current evidence on the impact of regional anesthesia or analgesia on cancer recurrence. RECENT FINDINGS: Preclinical investigations suggest that regional anesthesia could have a positive impact on reducing cancer growth and progression. Regional anesthesia is also associated with better immunological and stress-related outcomes in patients undergoing major oncological surgery. Most recent retrospective studies do not show any benefit of regional anesthesia or analgesia on cancer recurrence or recurrence-free survival. SUMMARY: The available clinical evidence does not support the use of any anesthesia technique to improve the cancer-related survival after major oncological surgery. The results from four randomized controlled trials will shed light on this critical topic in perioperative medicine.
PURPOSE OF REVIEW: To summarize the current evidence on the impact of regional anesthesia or analgesia on cancer recurrence. RECENT FINDINGS: Preclinical investigations suggest that regional anesthesia could have a positive impact on reducing cancer growth and progression. Regional anesthesia is also associated with better immunological and stress-related outcomes in patients undergoing major oncological surgery. Most recent retrospective studies do not show any benefit of regional anesthesia or analgesia on cancer recurrence or recurrence-free survival. SUMMARY: The available clinical evidence does not support the use of any anesthesia technique to improve the cancer-related survival after major oncological surgery. The results from four randomized controlled trials will shed light on this critical topic in perioperative medicine.
Authors: Bao-Jun Hou; Ying Du; Shu-Xin Gu; Jie Fan; Ran Wang; Hong Deng; Dan-Xia Guo; Li Wang; Yan-Ying Wang Journal: Medicine (Baltimore) Date: 2019-07 Impact factor: 1.817
Authors: Gustavo N C Inoue; Ruan Pimenta; Juliana A Camargo; Nayara I Viana; Vanessa R Guimarães; Miguel Srougi; William C Nahas; Katia R M Leite; Sabrina T Reis Journal: Ann Med Surg (Lond) Date: 2022-02-24