Thoracic Paravertebral Block Combined with General Anaesthesia or General Anaesthesia Alone for Thoracoscopic Lung Adenocarcinoma Surgery: A Retrospective Study.

Purpose: To investigate the effects of ultrasound-guided thoracic paravertebral block combined with general anaesthesia or general anaesthesia alone for thoracoscopic lung adenocarcinoma surgery, and to provide new thoughts for improving the clinical outcomes.
Methods: This was a retrospective study. Data were retrieved for 195 patients with lung adenocarcinoma undergoing elective radical lobectomy via video-assisted thoracoscopy between January 2018 and August 2019 in The Second Hospital of Shandong University, including 86 patients who received thoracic paravertebral block (TPVB) combined with general anaesthesia (group TG), and 109 patients who received general anaesthesia alone (group GA). All patients were given self-controlled intravenous analgesia pump for 48 h after surgery. The primary outcome was the recurrence-free survival 2 years postoperatively (the time between surgery and the earliest date of recurrence, metastasis or lung cancer-cause death). The secondary outcomes included the average numeric rating scale (NRS) scores within 48 h postoperatively, the first time of postoperative ambulation, duration of chest tube drainage, length of postoperative hospitalization, perioperative opioid consumption and the postoperative side effects.
Results: There were no statistical differences in the recurrence-free survival 2 years postoperatively between groups (Multivariate hazard ratio 0.706, 95% CI 0.126-3.941, P=0.691). The average NRS scores within 48 h postoperatively were significantly lower in group TG (P<0.05). The first time of postoperative ambulation, duration of chest tube drainage, and length of postoperative hospitalization in group TG were significantly reduced (P<0.05). Opioid consumption was significantly decreased in group TG (P<0.01). Finally, the incidence of postoperative nausea and vomiting (PONV) was significantly lower in group TG (P<0.05).
Conclusion: TPVB for thoracoscopic lung adenocarcinoma surgery did not improve the recurrence-free survival 2 years postoperatively compared with general anaesthesia alone, but it significantly enhanced the postoperative analgesia effect, reduced opioid consumption as well as side effects, and accelerated postoperative early recovery. Clinical Trial Registration Number: The Chinese Clinical Trial Registry (ChiCTR-2100050454).

Introduction

Lung cancer is a malignant tumour with the highest mortality among all cancers worldwide, and adenocarcinoma has been the most common histological subtype in the past few decades. At present, video-assisted thoracoscopic surgery (VATS) remains the best option for cure and favourable prognosis in the early stages, especially in Asian non-smoking related lung cancer screening program.1–5 Even if the neoplasm is completely resected, involving systemic lymph node dissection, the possibility of tumour recurrence or metastasis remains high because of undetected micro-metastasis.6 Development of cancer recurrences depends heavily on the balance between the anti-tumour immune activity of the body and the metastatic potential of cancer cells. Nevertheless, both surgery and anaesthesia can impair the host defense against malignant tumours.7 Surgical procedures release cancerous cells into the circulation, and surgery-related stress responses damage immunity, which all promote the growth of the neoplasm.8,9

For a long time, opioids have played an important role in perioperative analgesia. However, several studies have reported that they might cause deterioration of cell-mediated immunity and promote the development of tumours.10–12 Previous studies have shown that the appropriate choice of anaesthesia methods could reduce the stress response and protect the immune system, which would facilitate recovery from surgery.13,14 Although general anaesthesia is the most frequently approach to the surgery, it causes higher levels of inflammation and stronger immunosuppressive effects than regional anaesthesia.15 Studies have demonstrated that regional block analgesia technology, as an important method of multimodal analgesia, could generate efficient analgesic properties, lower the response to surgical stress, and also reduce immunosuppression through afferent nerve blockade. It might also potentially delay postoperative tumour recurrence.16–19

Along with the progress of ultrasound technology, thoracic paravertebral block (TPVB) is increasingly being used for analgesia in thoracic surgery. Moreover, it has many advantages such as providing effective analgesia, alleviating the inflammatory response as well as immunosuppression, stabilizing haemodynamics, reducing side effects, and accelerating postoperative rehabilitation.20–24 Two recent randomized trials investigated the effect of TPVB in breast cancer patients with cancer recurrence as the primary outcome, which shown that neither identified a recurrence benefit from TPVB.25,26 To a certain degree that regional analgesia might preserve host defense against cancer, the benefit is most likely in patients having operations that cause considerable tissue injury and are painful. Lung cancer surgery is far more invasive than breast surgery and thus triggers a far greater stress response, and more opioids are generally needed. In a retrospective cohort study, Lee et al27 study demonstrated that TPVB was not related to lung cancer recurrence, but it had a beneficial effect on overall survival of the patients. However, to our knowledge, no studies have compared the surgical outcomes between ultrasound-guided TPVB combined with general anaesthesia and general anaesthesia alone in VATS lung adenocarcinoma surgery. Here, in this retrospective study, we therefore tested the primary hypothesis that ultrasound-guided TPVB combined with general anaesthesia could improve recurrence-free survival compared with general anesthesia alone with intravenous analgesia in patients having potentially curative lung adenocarcinoma surgery. Secondarily, we tested the hypotheses that ultrasound-guided TPVB combined with general anaesthesia might enhance the postoperative early recovery.

Materials and Methods

Ethical Statement for Collecting Clinical Information

This is a retrospective study, which was approved by the Research Ethics Committee of the Second Hospital of Shandong University (No: KYLL-2021LW-065), registered in the Chinese Clinical Trial Registry (ChiCTR2100050454), and carried out in accordance with the Declaration of Helsinki. The written informed consent was waived because of no damage to patients or conflicts of interest. The confidentiality of patient data was guaranteed according to the requirements of the Ethics Committee.

Study Design and Patient Selection

A total of 195 lung adenocarcinoma patients undergoing elective radical lobectomy via VATS in the second hospital of Shandong University between January 2018 and August 2019 were included in this study. The data were extracted from the clinical electronic information system, patients and/or their family members who were familiar with the patients’ information were contacted by phone, and then the patients were divided into two groups according to the anaesthesia type: TPVB combined with general anaesthesia group (group TG, n=86) and general anaesthesia alone group (group GA, n=109). Inclusion criteria were: (1) ages 18 to 80 years; American Society of Anesthesiologists (ASA) grade I~III; (2) the diagnosis of lung adenocarcinoma (I~III A) by postoperative pathology; (3) the same surgical technique applied to all patients (all patients had undergone lobectomy and/or lymph node dissection by 2-VATS, which consisted of both surgical incision and observation incision. A 3~4 cm incision was made along the anterior axillary line in the 4th intercostal space to create the utility port, and another 1 cm incision was made along the midaxillary line in the 7th intercostal interspace for the observation port; (4) general anaesthesia alone or combined with TPVB was applied in all operations; (5) all anaesthesia and surgical management were carried out by the same team; (6) patients signed the informed consent for 48-h patient-controlled intravenous analgesia (PCIA), and sufentanil was used for emergency analgesia if PCIA could not be achieved satisfactorily. Exclusion criteria were: (1) severe neurological conditions (eg preoperative cognitive dysfunction), severe cardiopulmonary dysfunction, hepatic renal disease (Child-Pugh grade C and serum creatinine greater than 442 mol/L), autoimmune diseases, organ replacement therapy, haematological system disease, preoperative infectious diseases; (2) distant metastasis, other malignant tumours; (3) history of previous lung surgery, preoperative chemoradiotherapy or immune therapy, use of glucocorticoid or opioid analgesics within 6 months; (4) history of surgery/anaesthesia within 6 months; (5) contraindications or complications in response to PVB in group TG, including coagulation dysfunction, local infection, and local anaesthetic toxicity; (6) blood transfusion therapy or any allergic reaction during hospitalization; (7) conversion to thoracotomy; (8) failure to complete data collection and follow-up; (9) other serious accidents and complications during hospitalization (eg cardiac failure, respiratory failure, reoperation for postoperative bleeding, pulmonary embolism.).

Anaesthesia Methods

All patients were regularly monitored by electrocardiography (ECG), pulse oxygen saturation (SPO2), invasive blood pressure (IBP), end-tidal carbon dioxide (ETCO2) concentration, body temperature and bispectral index (BIS) values. Before induction of general anaesthesia, the unilateral TPVB20 was performed under ultrasonic guidance in group TG. Patients were placed in the lateral position, and a high-frequency linear array probe (11MHz, Vivid S70N, GE Healthcare) was applied in a parasagittal orientation to distinguish the intended transverse processes (T4 and T7). After identifying the pleura and superior costotransverse ligament, a 21 G, 100 mm needle (Facet NanoLine) was advanced slowly with an in-plane technique from a lateral to medial direction, until the tip punctured the superior costotransverse ligament and entered the paravertebral space. Then, the position of the needle tip was confirmed by hydrodissection. Following confirmation, 10 mL of 0.375% ropivacaine solution was injected, and depression of the pleura was clearly seen on the ultrasound image (Figure 1). After 10–30 min of injection, if the local blocks were satisfactory, general anaesthesia was performed in group TG. Both patient groups were given double-lumen endotracheal intubation anaesthesia (one-lung ventilation was implemented, as needed) with propofol, sevoflurane, sufentanil, and rocuronium bromide, and 48-h PCIA was performed immediately after surgery. The formula was: sufentanil 2 μg/kg and tropisetron 5 mg diluted to 100 mL with normal saline, the background dose was 2 mL/h, initial load was 5 mL, locking time was 15 min, and additional amount was 0.5 mL.

Figure 1

Ultrasound image of the thoracic paravertebral block. The red arrow denotes the puncture path of the needle. Compared with the picture above, the pleura in the picture below is being pressed down by the local anaesthetics.

Outcomes

The primary outcome was the recurrence-free survival at postoperative year 2, which was defined as the time between surgery and the earliest date of recurrence, metastasis or lung cancer-cause death, whichever came first.

(2) The secondary outcomes were as follows: I. The average numerical rating scale (NRS) scores (from 0 to 10: 0 as painless, 10 as extremely painful) within 48 h after surgery. II. The recovery of the patients, including the first time of postoperative ambulation, duration of chest tube drainage, and length of postoperative hospitalization. III. Opioid analgesics used during intraoperative and postoperative 48-h sufentanil dosage. IV. The side effects within 48 h after surgery, including lethargy, postoperative nausea and vomiting (PONV), itching, urinary retention, hypotension and bradycardia.

Statistical Analysis

All statistical analyses were performed using SPSS 23.0 software (IBM Corp, Armonk, NY, USA). Quantitative variables were presented as mean ± standard deviation (SD), and qualitative variables were presented as numbers (proportion). The independent-sample t-test, Mann–Whitney U-test, chi-square (χ2) test and Fisher’s exact test were applied to analyse the differences between groups according to the type of data. Recurrence-free survival at postoperative year 2 was analysed using a Kaplan–Meier estimator with differences between groups assessed by Log rank test. A Cox proportional hazard model was used to analyse the factors predetermined according to clinical importance and included sex, age, smoking status, ASA, intraoperative and postoperative sufentanil dosage, tumour stage, treatment regime. Effect size was expressed as hazard ratio and 95% CI. The interactions between treatment effect and predefined factors as above were assessed separately with Cox proportional hazard models. All comparisons were two-sided and differences were regarded as statistically significant (P<0.05).

Results

Eventually, between January 02, 2018, and August 30, 2019, a total of 195 patients with thoracoscopic lung adenocarcinoma surgery were enrolled, including 86 patients in group TG and 109 patients in group GA who met the criteria for this study (Figure 2). Baseline characteristics were generally comparable in the two groups. The patients in both the groups did not differ significantly in terms of sex, age, weight, body mass index (BMI), smoking status, ASA, PaO2 (partial pressure of arterial oxygen), PaCO2 (partial pressure of arterial carbon dioxide), preoperative haemoglobin level, sevoflurane, propofol, duration of anaesthesia, duration of surgery, intraoperative blood loss, urine volume, type of lobectomy, tumour stage, or treatment regime (P>0.05, Table 1). There were no statistically significant or clinically meaningful differences in recurrence-free survival at postoperative year 2 between groups (Multivariate hazard ratio 0.706, 95% CI 0.126–3.941, P=0.691, Figure 3). We also conducted the Cox regression analyses for the total study to determine clinically significant risk factors for lung adenocarcinoma recurrence. As a result, the tumour stage (III) and treatment regime (other treatment) were found to be associated with higher risks of the cancer recurrence (Table 2).The average NRS score within 48 h postoperatively in group TG was significantly lower compared with that of group GA (P<0.05, Figure 4). Regarding postoperative early recovery, the first time of postoperative ambulation, duration of chest tube drainage, and length of postoperative hospitalization in group TG were significantly reduced compared with those in group GA (P<0.05, Figure 5). The dosage of intraoperative and postoperative sufentanil in group TG was significantly lower than in group GA (P<0.01, Figure 6). The group TG had a significantly lower incidence of PONV (P<0.05, Table 3). In addition, no significant differences were noted in other side effects between the two groups (P>0.05, Table 3).

Figure 2

Flow diagram of the study.

Table 1

Comparison of Demographic Data and Characteristics in the Two Groups

Characteristics	Group TP (n=86)	Group GA (n=109)	P value
Age, (year)	57.6±8.7	60.1±9.8	0.06#
Sex, n (%)
Male	51 (59.3)	57 (52.3)	0.33£
Female	35 (40.7)	52 (47.7)
Weight (kg)	65.2±11.2	63.0±10.6	0.16#
BMI (kg/m2)	23.1±1.4	22.8±1.1	0.07#
Smoking status, n (%)	26(30.2)	37(33.9)	0.65£
ASA grade, n (%)
I	12 (14.0)	11 (10.1)	0.67£
II	66 (76.7)	89 (81.6)
III	8 (9.3)	9 (8.3)
PaO2 (mmHg)	86.6±7.9	84.6±8.4	0.10#
PaCO2 (mmHg)	41.3±5.6	42.5±4.9	0.12#
Haemoglobin (g/L)	134.8±18.3	133.1±18.6	0.52#
Sevoflurane (mL)	42.1±6.5	43.3±5.9	0.18#
Propofol (mg)	906.7±213.9	901.1±198.0	0.85#
Duration of anaesthesia (min)	166.1 ± 22.3	171.3 ± 23.1	0.12#
Duration of surgery (min)	134.9 ± 22.2	138.7 ± 19.1	0.19#
Intraoperative blood loss (mL)	69.7±23.1	73.6±27.6	0.29#
Urine volume (mL)	123.6±26.8	118.7±24.2	0.19#
Type of lobectomy, n (%)
Left upper	15 (17.4)	21 (19.3)	0.51£
Left lower	12 (14.0)	17 (15.6)
Right upper	20 (23.3)	29 (26.6)
Right middle	14 (16.3)	22 (20.2)
Right lower	25 (29.0)	20 (18.3)
Tumour stage, n (%)
I	61 (70.9)	70 (64.2)	0.36£
II	15 (17.5)	18 (16.5)
III A	10 (11.6)	21 (19.3)
Treatment regime, n (%)
Surgery only	57 (66.3)	75 (68.8)	0.58Δ
Surgery &chemotherapy	16(18.6)	13 (11.9)
Surgery &radiation	1 (1.2)	2 (1.8)
Surgery&chemotherapy and radiation	0	0
Other treatment	12 (14.0)	19 (17.4)

Notes: The data are given as mean ± SD or n (%). Quantitative variables were compared by #independent-sample t; Qualitative variables were compared by £Chi-square (χ2) or ΔFisher’s exact test.

Abbreviations: TG, thoracic paravertebral block combined with general anaesthesia alone; GA, general anaesthesia alone; BMI, body mass index; ASA, American Society of Anesthesiologists; PaO2, partial pressure of arterial oxygen; PaCO2, partial pressure of arterial carbon dioxide; SD, standard deviation.

Figure 3

Comparison of Kaplan–Meier survival curves for the 2-year postoperative recurrence-free survival between groups. There were no statistical differences in the 2-year postoperative recurrence-free survival between groups (multivariate hazard ratio 0.706, 95% CI 0.126–3.941, P=0.691).

Table 2

Cox Regression Analysis for Recurrence-Free Survival at Postoperative Year 2

	Univariate			Multivariate
Variables	HR	95% CI	P value	HR	95% CI	P value
Type of anaesthesia
GA	Reference			Reference
TG	0.702	0.235–2.096	0.527	0.706	0.126–3.941	0.691
Tumour stage
I	Reference			Reference
II	0.851	0.184–3.940	0.837	0.136	0.015–1.743	0.077
III	1.467	0.397–5.419	0.566	0.022	0.001–0.734	0.033
Treatment regime
Surgery only	Reference			Reference
Surgery & chemotherapy	0.979	0.212–4.532	0.978	5.372	0.438–65.935	0.189
Surgery & radiation	5.394	0.682–42.657	0.110	17.585	0.641–6482.186	0.080
Other treatment	0.960	0.207–4.443	0.958	159.206	1.953–12,377.670	0.024
ASA status
I	Reference			Reference
II	0.856	0.288–2.548	0.780	1.207	0.119–12.236	0.874
III	0.722	0.089–5.866	0.760	1.170	0.119–11.507	0.893
Sex
Male	Reference			Reference
Female	0.576	0.200–1.660	0.307	0.682	0.183–2.545	0.569
Smoking status
Yes	Reference			Reference
No	0.838	0.263–2.670	0.764	0.682	0.183–2.545	0.569
Age, yr
Age <60	Reference			Reference
Age ≥60	1.154	0.400–3.326	0.791	1.243	0.374–4.131	0.722
IPSD	1.016	0.996–1.036	0.122	1.018	0.990–1.047	0.192

Notes: Only the clinically meaningful clinicopathologic and perioperative variables were included in the univariate and multivariate ananlysis, which were analysed by Cox proportional hazards regression. Associations with P < 0.05 were considered statistically significant.

Abbreviations: TG, thoracic paravertebral block combined with general anaesthesia alone; GA, general anaesthesia alone; ASA, American Society of Anesthesiologists; HR, hazard ratio; CI, confidence interval; IPSD, intraoperative and postoperative sufentanil dosage.

Figure 4

Comparison of the average pain scores 48 h postoperatively between groups. The data are given as mean ± SD, compared with group GA, *P<0.05. Data were compared by independent-sample t-test.

Figure 5

Comparison of postoperative early recovery between groups. The first time of postoperative ambulation (A), the duration of chest tube drainage (B), the length of postoperative hospitalization (C). The data are given as mean ± SD, compared with group GA, *P<0.05. Data were compared by independent-sample t-test.

Figure 6

Comparison of intraoperative and postoperative sufentanil dosage between groups. The data are given as mean ± SD, compared with group GA, *P<0.01. Data were compared by independent-sample t-test.

Table 3

Comparison of Side Effects After Operation (n (%))

Indicators	Group TG (n=86)	Group GA (n=109)	P value
Drowsiness	2 (2.3%)	5 (4.6%)	0.47
PONV	3 (3.5%)*	13 (11.9%)	0.03
Itching	1 (1.1%)	7 (6.9%)	0.08
Respiratory depression	1 (1.1%)	4 (3.4%)	0.39
Urinary retention	0	5 (10.3%)	0.07
Hypotension	0	2 (3.4%)	0.50
Bradycardia	0	1 (%)	1.00

Notes: The data are given as n (%). Qualitative variables were compared by Fisher’s exact test. Compared with group GA, *P<0.05.

Abbreviations: TG, thoracic paravertebral block combined with general anaesthesia alone; GA, general anaesthesia alone; PONV, postoperative nausea and vomiting.

Discussion

The most important findings of this study were that the ultrasound-guided TPVB in thoracoscopic lung adenocarcinoma surgery did not improve the recurrence-free survival at postoperative year 2, but it significantly enhanced the postoperative analgesia effect, reduced opioid consumption as well as side effects, and accelerated postoperative early recovery.

Surgical resection is the preferred technique for lung adenocarcinoma treatment, yet surgical trauma can lead to a range of systemic metabolic, inflammatory, and neuroendocrine responses. As a result, the immune surveillance function of patients is suppressed, which may promote cancer progression after surgery.28 It was recently reported that besides surgical trauma, various perioperative factors can influence the anti-tumour immune response and are linked with cancer recurrence. Among these factors, anaesthesia methods are receiving increasing attention.29 According to the current relevant literature, regional anaesthesia influences cancer recurrence, metastasis and survival, generally through three main mechanisms: abrogation of the adrenergic-inflammatory response to surgical insult and systemic effects of local anaesthetic agents and/or opioid-sparing analgesia. However these proposals remain controversial.6,10,30 Although some observational studies in cancer patients revealed beneficial effects of regional anaesthesia, most others did not.31,32 In a retrospective 12-year follow-up after breast cancer surgery, Kairaluoma et al33 demonstrated that TPVB did not improve the prognosis of patients with breast cancer. A 5-year follow-up of a randomized controlled trial by Karmakar et al26 suggested that TPVB had little to no appreciable effect on local recurrence, metastasis or mortality after breast cancer surgery. Furthermore, in a recent randomized trial, Xu et al7 reported that the overall survival was comparable in 400 lung patients undergoing pulmonectomy with combined epidural–general anaesthesia or general anaesthesia alone. Sessler et al34 showed the regional anaesthesia-analgesia (paravertebral block) did not reduce breast cancer recurrence after potentially curative surgery compared with volatile anaesthesia (sevoflurane) and opioids in a randomized controlled trial. However, a retrospective analysis by Exadaktylos et al35 suggested that TPVB and postoperative analgesia can reduce the risk of recurrence and metastasis in breast cancer patients during the initial years of follow-up after mammectomy. In a randomized, controlled clinical trial, Chu et al6 demonstrated that TPVB attenuated matrix metalloproteinase-9 (MMP-9) response to VATS lobectomy, which may be beneficial for patients by reducing postoperative tumour recurrence. To date, there are few studies on the effect of TPVB on lung adenocarcinoma, nevertheless our outcome firstly showed that TPVB had no effect on the recurrence-free survival at postoperative year 2 in patients with lung adenocarcinoma. The most likely factors are as follows: shorter surgery time, lower stress response, fewer opioids, relatively stable perioperative immune function, earlier pathological stage and shorter follow-up time.

VATS is a commonly performed minimally invasive procedure that has helped to reduce levels of pain, but pain remains an issue associated with VATS, especially for the first 3 days after surgery, and it requires analgesia that blocks both visceral and somatic nerve fibres for more effective pain control so as to improve postoperative outcome.36–38 It has been reported that regional techniques combined with general anaesthesia provide better perioperative analgesia by completing the somatosensorial and sympathetic block and have an opioid analgesic sparing effect.39 The results of our study suggest that the average NRS score within 48 h postoperatively in group TG was significantly lower than that in group GA (P<0.05), which is consistent with the results of Qiu et al40 who found that TPVB provided analgesia that was superior to general anaesthesia alone during the initial 2 h after VATS in a noninferiority randomized trial. Our results are also similar to those from a study by Chu et al6 who demonstrated that TPVB could provide statistically better pain relief in VATS lobectomy in a randomized clinical trial. What is more, Turhanet al.37 reported that TPVB appeared to be the preferable method with more successful analgesia of the erector spinae plane block (ESPB) and intercostal nerve block (ICNB) in thoracoscopic surgery.

There are a variety of factors affecting the speed of early postoperative recovery, including the extent of surgical trauma, postoperative analgesia, early postoperative activities, duration of chest tube drainage, and length of postoperative hospitalization.41 Our findings showed that these parameters (the first time of postoperative ambulation, duration of chest tube drainage, and length of postoperative hospitalization) were significantly reduced in group TG in comparison with those in group GA (P<0.05). The results are similar to those of Ma et al42 who demonstrated shorter drainage duration and reduced postoperative hospital stay in the TPVB group versus the control group after VATS. A randomized, double-blind study by Kang et al22 suggested that TPVB could significantly promote postoperative early rehabilitation in patients who received thoracoscopic radical lung cancer surgery compared with GA. In a randomized trial, Zhang et al43 study revealed that TPVB could enhance recovery, protect against independent lung injury and cellular immunity. In other words, this is in line with the concept of enhanced recovery after surgery (ERAS) to restore preoperative organ function, reduce perioperative stress response, and as a consequence, accelerate recovery.

The dosage of intraoperative and postoperative sufentanil in group TG was significantly lower than in group GA (P<0.01). This indicated that TPVB could significantly reduce perioperative pain, which was consistent with the results of Qiu et al40 who found that PTVB reduced the use of sufentanil during surgery by about 30%, and that patients required smaller amounts of rescue drugs within 24 h after operation. Zhang et al43 demonstrated that the reduced consumption of remifentanil occurred in response to TPVB in patients undergoing pulmonary surgery in a randomized trial. In addition, Turhanet al.37 reported that TPVB appeared to lower the morphine requirement in contrast to ICNB or ESPB in thoracoscopic surgery.

Surgical factors, residual anaesthetics and postoperative analgesics may cause adverse reactions, such as drowsiness, PONV, itching, urinary retention, bradycardia and hypotension. The results showed that the incidence of adverse reactions (PONV) after surgery in group TG was significantly lower than those in group GA (P<0.05), which was consistent with previous studies.40,44,45 All these results implied that the TPVB and the opioid were secure.

There were several limitations in this study. Firstly, this study was retrospective and from a single centre; incomplete documentation and recall bias regarding history added to the complexity of the study, and a multicentre randomized prospective trial should be conducted for further validation of these results. Secondly, the follow-up period of postoperative analgesic efficacy was only 48h, and a longer follow-up period is needed to validate the findings. Thirdly, very few patients might undergo lobectomy and segmental (wedge) resection simultaneously, which probably affects the accuracy of the outcomes. Finally, since our conclusion was based on a single centre study, a multi-centre study with more cases might further confirm the validity of our results.

Conclusions

This retrospective study demonstrated that TPVB for thoracoscopic lung adenocarcinoma surgery did not improve the recurrence-free survival at postoperative year 2 compared with general anaesthesia alone, but it significantly enhanced the postoperative analgesia effect, reduced opioid consumption as well as side effects, and accelerated postoperative early recovery.